Article
Multidisciplinary Sciences
Paulo E. A. S. Camara, Graciele C. A. Menezes, Otavio H. B. Pinto, Micheline C. Silva, Peter Convey, Luiz H. Rosa
Summary: DNA analysis of Antarctic glacial ice revealed the presence of green algae and flowering plant DNA. The green algae may indicate a viable algal community in the ice, while the presence of flowering plant DNA is likely due to pollen or tissue fragments introduced by humans.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)
Article
Genetics & Heredity
Hu Fang, Helen H. N. Yan, Rebecca A. Bilardi, Christoffer Flensburg, Haocheng Yang, Jayne A. Barbour, Hoi Cheong Siu, Michelle Turski, Edward Chew, Zhen Xu, Siu T. Lam, Rakesh Sharma, Mengya Xu, Junshi Li, Ho W. Ip, Carol Y. M. Cheung, Michael S. Y. Huen, E. Alejandro Sweet-Cordero, Ian J. Majewski, Suet Y. Leung, Jason W. H. Wong
Summary: This retrospective cohort study analyzed genomics data of 121,771 patients who had undergone targeted sequencing and found that GCV can cause a diverse range of cancers, and its mutagenicity may be potentiated by other therapies, such as mycophenolate mofetil (MMF).
Editorial Material
Plant Sciences
Craig R. Brodersen
Summary: This study found that the thickness of intervessel pit membrane among different accessions of Arabidopsis thaliana best explains the variation in embolism resistance in stems.
Review
Medical Laboratory Technology
Mercy Thomas, Winita Hardikar, Ronda F. Greaves, David G. Tingay, Tze Ping Loh, Vera Ignjatovic, Fiona Newall, Anushi E. Rajapaksa
Summary: Research on hepatic membrane transporters has contributed to a greater understanding of bilirubin homeostasis. Recent insights suggest that a proportion of conjugated bilirubin may be excreted via the renal system, even in normal physiological jaundice. Targeting the altered renal excretory pathway may have clinical relevance in screening for neonatal jaundice.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Gustavo Burin, Paulo R. Guimaraes Jr, Tiago B. Quental
Summary: The study found that bird species contributing most to the structure of plant-frugivore interaction networks belong to lineages with higher macroevolutionary stability. This association is stronger in warmer, wetter, less seasonal environments.
Article
Medicine, Research & Experimental
Bezawit A. Woldemeskel, Arbor G. Dykema, Caroline C. Garliss, Saphira Cherfils, Kellie N. Smith, Joel N. Blankson
Summary: Recent studies have found that vaccinated individuals possess T cells that can recognize both SARS-CoV-2 and common cold coronaviruses. This study identified a conserved epitope (S815-827) in the spike protein of SARS-CoV-2, which is also present in other coronaviruses including those from bats. The researchers found that 42% of vaccinated participants recognized this epitope and that CD4(+) T cells from responders could cross-recognize similar peptides from other coronaviruses. This suggests that the current mRNA vaccines may provide some protection against future zoonotic outbreaks and informs the development of pan-coronavirus vaccine strategies.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Environmental Sciences
Mustafa Senkaya, Ali Erden Babacan, Hakan Karsli, Bekir Taner San
Summary: This paper investigates the origins of different displacements in the Isiklar paleo-landslide area using multiple geophysical methods. The results suggest that the variation of displacements is controlled by the dissimilarity of landslide materials in terms of geological setting, S-wave velocity, and layer thickness. The slope values higher than 30% play a crucial role in the development of scarps in the fields. Seasonal changes and ground-water conditions do not significantly influence the variability in displacements.
ENVIRONMENTAL EARTH SCIENCES
(2022)
Article
Multidisciplinary Sciences
Annika Nelde, Jonas Rieth, Malte Roerden, Marissa L. Dubbelaar, Naomi Hoenisch Gravel, Jens Bauer, Reinhild Klein, Tobias Hoheisel, Hartmut Mahrhofer, Siri Goepel, Michael Bitzer, Sebastian Hoerber, Andreas Peter, Jonas S. Heitmann, Juliane S. Walz
Summary: Levels of soluble HLA molecules (sHLA) are significantly increased in COVID-19 patients and convalescent individuals, positively correlating with SARS-CoV-2-directed cellular immunity. Severe COVID-19 cases show reduced sHLA levels. The soluble immunopeptidome in COVID-19 patients exhibits increased diversity of HLA-presented peptides, and a SARS-CoV-2-derived peptide from the viral nucleoprotein is identified. Levels of sHLA directly correlate with the diversity of the soluble immunopeptidome.
Article
Biochemistry & Molecular Biology
Karl-Heinz Wagner, Nazlisadat Seyed Khoei, Claudia Anna Hana, Daniel Doberer, Rodrig Marculescu, Andrew Cameron Bulmer, Marlies Hoermann-Wallner, Christine Molzer
Summary: Subjects with Gilbert's syndrome show higher levels of antioxidant potential and protein oxidation products, as well as lower levels of apolipoprotein B, hs-C-reactive protein, interleukin 6, and interleukin 1 beta compared to healthy controls. Resting heart rate is also significantly lower in the GS group. Older subjects with GS demonstrate stronger protective effects.
Article
Biology
Andrew B. Leslie, Luke Mander
Summary: Reproductive structures of vascular plants have become more complex over time, with highly differentiated parts interacting in specialized ways. This study shows that interactions within reproductive structures have generally increased over time, leading to more compact and functionally integrated structures. These processes are widespread across plant lineages, but vary in extent and timing depending on the reproductive biology.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Oncology
Xiancong Huang, Yang Chen, Huan Yang, Ruting Wang, Zhongjian Chen
Summary: This study investigates the prognostic value of preoperative serum bilirubin in ESCC patients who underwent curative resection. The higher levels of unconjugated bilirubin, conjugated bilirubin, and total bilirubin were associated with longer overall survival. All three forms of bilirubin were identified as independent prognostic factors for ESCC patients. In vitro and in vivo models confirmed the inhibitory effect of unconjugated bilirubin on ESCC proliferation.
Review
Plant Sciences
Li He, Elvira Hoerandl
Summary: Dioecy, controlled by sex-linked regions (SLRs), is rare in flowering plants and plants do not commonly have degenerated sex chromosomes like in animals. Constraints created at the origin of polyploids limit successful polyploidization of species with SLRs.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Afia Tasnim Rahman, Jongoh Shin, Chang-Hee Whang, Wonsik Jung, Dohyun Yoo, Changjin Seo, Byung-Kwan Cho, Sangyong Jon
Summary: This study reports a nanomedicine composed of bilirubin-attached low-molecular-weight, water-soluble chitosan nanoparticles that can promote restoration of intestinal barrier, mucosal immunity, and gut microbiome homeostasis, thereby exhibiting robust therapeutic efficacy.
Review
Environmental Sciences
Divjot Kour, Tanvir Kaur, Rubee Devi, Ashok Yadav, Manali Singh, Divya Joshi, Jyoti Singh, Deep Chandra Suyal, Ajay Kumar, Vishnu D. Rajput, Ajar Nath Yadav, Karan Singh, Joginder Singh, Riyaz Z. Sayyed, Naveen Kumar Arora, Anil Kumar Saxena
Summary: The rapid development of agriculture and industries in the past decades has led to environmental contamination by various pollutants. Bioremediation using microorganisms has emerged as an efficient, widespread, cost-effective, and eco-friendly cleanup tool. Utilizing microbes for managing environmental pollution is a promising technology.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Immunology
Xijing Huang, Yan Pan, Ya Liu, Zhou Zhou, Yinghui Zhang, Caiping Gao, Chong He
Summary: This study aimed to verify the practical value of NBR in monitoring disease activity in UC patients. The results showed a positive correlation between NBR and clinical and endoscopic disease activity in UC. Additionally, NBR was significantly lower in patients with endoscopic mucosal healing. This study suggests that NBR may be a promising candidate for assessing disease activity in UC.
JOURNAL OF INFLAMMATION RESEARCH
(2023)