Review
Biochemistry & Molecular Biology
Mohd Saquib, Prachi Agnihotri, Sagarika Monu, Sagarika Biswas
Summary: Inflammation and autoimmunity are the root cause of rheumatoid arthritis, a destructive disease of joints. RNA, especially non-coding RNA, plays important roles in regulating inflammation and disease pathogenesis. Studying the involvement of non-coding RNA in early RA development can lead to a better understanding of the disease and potential therapeutic targets.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Neurosciences
Amber Penning, Giorgia Tosoni, Oihane Abiega, Pascal Bielefeld, Caterina Gasperini, Davide De Pietri Tonelli, Carlos P. Fitzsimons, Evgenia Salta
Summary: The adult neurogenic niches are complex multicellular systems where adult neural stem cells generate astrocytic and neuronal progeny, functionally linked to memory, cognition, and mood regulation. Deregulation of aNSCs and their progeny can impact aging and various brain pathologies. Non-coding RNAs have emerged as key regulators in NSC fate determination, providing potential therapeutic avenues for neurological diseases.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Anshika Goenka, Deanna Marie Tiek, Xiao Song, Rebeca Piatniczka Iglesia, Minghui Lu, Bo Hu, Shi-Yuan Cheng
Summary: Research in cancer biology has predominantly focused on protein-coding genes, but the discovery of non-coding RNAs (ncRNAs) has shed light on their crucial role in various biological processes and human diseases including cancer. Dysregulated ncRNA expression affects cancer initiation, progression, and therapy resistance. This review emphasizes the recent developments and advances in ncRNA biology relevant to glioma tumorigenesis and therapy response, highlighting the potential of ncRNAs as biomarkers and therapeutic agents in glioma.
Review
Endocrinology & Metabolism
Meghali Joshi, Shruti Sethi, Poonam Mehta, Anamika Kumari, Singh Rajender
Summary: Small non-coding RNAs (sncRNAs) play crucial roles in male reproduction, especially in spermatogenesis. miRNAs, piRNAs, and tsRNAs are the most commonly studied sncRNAs. Dysregulation of miRNAs is highly correlated with infertility. Sperm-borne small RNAs have the potential to act as biomarkers of sperm quality and fertility.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Qian-Yi Zhang, Hao Zhou, Xiao-Xiao Zhou, Feng-bin Yu, Yu-Yi Liu, Zhi-Yang Chen, Yi-Qun Ma, Xi -Lei Li, Bo Tian
Summary: This study explores the role of small noncoding RNAs (sncRNAs) in chondrocyte senescence. Small RNA sequencing and qPCR analysis reveal differential expression of multiple types of sncRNAs in senescent chondrocytes. Further experiments demonstrate that certain sncRNAs can restrain or promote chondrocyte senescence. These findings suggest that sncRNAs may serve as therapeutic targets for age-related osteoarthritis.
Review
Endocrinology & Metabolism
Guanqing Zhou, Mimi Zhang, Jingzhi Zhang, Yaofeng Feng, Zhishen Xie, Siyi Liu, Detu Zhu, Yumei Luo
Summary: Non-coding RNAs play important roles in cell differentiation, proliferation, apoptosis, and the pathogenesis of various diseases. Especially in non-obstructive azoospermia, the expression of non-coding RNAs is associated with pathological conditions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Carlos Garcia-Padilla, Estefania Lozano-Velasco, Virginio Garcia-Lopez, Amelia Aranega, Diego Franco, Virginio Garcia-Martinez, Carmen Lopez-Sanchez
Summary: Heart failure is a complex clinical syndrome with increasing prevalence, and finding new molecular biomarkers is an interesting tool to improve its prevention, diagnosis, treatment, and prognosis. This review emphasizes the relevance of microRNAs, long non-coding RNAs, and circular RNAs as potential biomarkers in heart failure. Further studies in this field are crucial to support their widespread clinical use.
Article
Oncology
Hong Zhang, Hong-Liang Duan, Sen Wang, Yang Liu, Guo-Nan Ding, Rui-Xin Lin
Summary: Thyroid cancer has become more prevalent in women and young adults in recent years. MicroRNAs (miRNAs) have been identified as potential epigenetic markers for thyroid cancer progression and metastasis, offering potential therapeutic targets.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Reproductive Biology
Jocelyn M. Cuthbert, Stewart J. Russell, Irina A. Polejaeva, Qinggang Meng, Kenneth L. White, Abby D. Benninghoff
Summary: The study investigated the dynamic changes in relative abundance of sncRNAs during the maternal-to-embryonic transition in bovine embryos produced by scNT and IVF, revealing that only a few miRNAs showed differential expression in morulae. More miRNAs were differentially expressed across developmental stages, and distinct populations of piRNAs were identified during embryonic genome activation process, highlighting the differences in sncRNA profiles before and after the MET.
BIOLOGY OF REPRODUCTION
(2021)
Review
Cell Biology
Nasrin Ahangar Davoodi, Sajad Najafi, Zari Naderi Ghale-Noie, Ashkan Piranviseh, Samaneh Mollazadeh, Sahar Ahmadi Asouri, Zatollah Asemi, Mohammadamin Morshedi, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Amirhossein Sheida, Hamed Mirzaei
Summary: Retinoblastoma (RB) is a rare aggressive intraocular malignancy of childhood that can have severe consequences. Non-coding RNAs (ncRNAs) play important roles in the pathogenesis and development of RB, with different ncRNAs acting as either tumor promoters or suppressors. Understanding the regulatory mechanisms of ncRNAs provides new opportunities for RB therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yu Wang, Tianhua Liu, Wenying Xiao, Yanyan Bai, Dandan Yue, Liuliu Feng
Summary: Atherosclerosis (AS) is a common cardiovascular disease characterized by endothelial cell injury and dysfunction. Oxidative low-density lipoprotein (Ox-LDL) is a key risk factor for AS development. This study identified the expression changes of small non-coding RNAs (sncRNAs) in Ox-LDL-treated endothelial cells, providing new markers for the diagnosis and treatment of endothelial cell injury.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cell Biology
Jihui Lee, Hara Kang
Summary: Sarcopenia is an age-related disease that can be regulated by alterations in the expression levels of non-coding RNAs, leading to muscle atrophy and dysfunction. Exercise can affect the expression patterns of non-coding RNAs involved in sarcopenia.
Review
Biochemistry & Molecular Biology
Nicole R. DeSouza, Danielle Quaranto, Michelle Carnazza, Tara Jarboe, Raj K. Tiwari, Jan Geliebter
Summary: RNA biology has gained recognition in the past two decades through the discovery of novel transcriptomic elements and functions. Differential gene expression patterns of wild-type loci have contributed to the understanding of molecular mechanisms driving carcinogenic transformation. Non-coding RNA molecules, particularly long non-coding RNA expression, play a role in cellular activity and pathological cell transformation, expanding cancer studies and molecular targeting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Lei Shi, Peter Magee, Matteo Fassan, Sudhakar Sahoo, Hui Sun Leong, Dave Lee, Robert Sellers, Laura Brulle-Soumare, Stefano Cairo, Tiziana Monteverde, Stefano Volinia, Duncan D. Smith, Gianpiero Di Leva, Francesca Galuppini, Athanasios R. Paliouras, Kang Zeng, Raymond O'Keefe, Michela Garofalo
Summary: This study reveals the role of KIMAT1 in maintaining KRAS signaling in lung cancer progression, suggesting that targeting it may be a strategy to prevent KRAS-induced tumorigenesis.
NATURE COMMUNICATIONS
(2021)
Article
Public, Environmental & Occupational Health
Bambarendage P. U. Perera, Rachel K. Morgan, Katelyn M. Polemi, Kimmie E. Sala-Hamrick, Laurie K. Svoboda, Dana C. Dolinoy
Summary: This review discusses the available genome and epigenome editing technologies, emphasizing the potential role of non-coding RNA as a tool for targeted epigenome editing. Advances in zinc finger nucleases, transcription activator-like effector nucleases, and CRISPR/Cas have significantly improved genome editing technology. Future developments in non-coding RNA have the potential to overcome the limitations of global modification and allow for locus-specific epigenome editing.
CURRENT ENVIRONMENTAL HEALTH REPORTS
(2022)
Article
Andrology
A. Mukherjee, S. Koli, K. V. R. Reddy
Article
Developmental Biology
Swanand Koli, Ayan Mukherjee, Kudumula Venkata Rami Reddy
REPRODUCTION FERTILITY AND DEVELOPMENT
(2017)
Article
Multidisciplinary Sciences
Debarchana Saha, Swanand Koli, Mandar Patgaonkar, Kudumula Venkata Rami Reddy
Article
Genetics & Heredity
Swanand Koli, Cassandre Labelle-Dumais, Yin Zhao, Seyyedhassan Paylakhi, K. Saidas Nair
Summary: This study reveals the complex interactions between genetic factors in the retina and RPE in ocular refractive development, with Adamts19 as a compensatory mechanism for ocular axial length reduction. PRSS56 and MFRP are crucial for pathological ocular elongation, and the upregulation of retinal Adamts19 serves as an adaptive molecular response to impaired ocular growth.
Article
Multidisciplinary Sciences
K. Saidas Nair, Chitrangda Srivastava, Robert V. Brown, Swanand Koli, Helene Choquet, Hong Soon Kang, Yien-Ming Kuo, Sara A. Grimm, Caleb Sutherland, Alexandra Badea, G. Allan Johnson, Yin Zhao, Jie Yin, Kyoko Okamoto, Graham Clark, Terete Borras, Gulab Zode, Krishnakumar Kizhatil, Subhabrata Chakrabarti, Simon W. M. John, Eric Jorgenson, Anton M. Jetten
Summary: Dysfunction of the trabecular meshwork (TM) is the chief cause of elevated intraocular pressure, the major risk factor of glaucoma. The authors identify the transcription factor, GLIS1, as a critical regulator of TM maintenance and intraocular pressure, and as a glaucoma risk gene.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Debarchana Saha, Swanand Koli, Kudumula Venkata Rami Reddy
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2017)