期刊
ACS INFECTIOUS DISEASES
卷 1, 期 5, 页码 198-202出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsinfecdis.5b00017
关键词
onchocerciasis; tropolones; molting
资金
- NIH Grant [AI092076]
The anthelmintic closantel has shown promise in abrogating the L3 molting of Onchocerca volvulus, the causative agent of the infectious disease onchocerciasis. In our search for alternative scaffolds, we utilized a fragment replacement/modification approach to generate novel chemotypes with improved chitinase inhibitory properties. Further evaluation of the compounds unveiled the potential of urea-tropolones as potent inhibitors of O. volvulus L3 molting.
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