期刊
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
卷 34, 期 3, 页码 321-328出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/00952990802013664
关键词
circadian rhythm; cortisol; detoxification; heroin abstainers
资金
- NATIONAL INSTITUTE ON DRUG ABUSE [ZIADA000536, K05DA000454] Funding Source: NIH RePORTER
- Intramural NIH HHS [Z99 DA999999] Funding Source: Medline
- NIDA NIH HHS [K05-DA0454, K05 DA000454] Funding Source: Medline
Several studies indicate abnormalities in the hypothalamic-pituitary-adrenal axis (HPA) during acute opiate withdrawal, but protracted withdrawal has gotten less study. The current study further characterized the 24-hour time course of plasma cortisol levels in heroin-dependent individuals who were abstinent for 10-15 days, which is beyond the 5 days of acute withdrawal, compared to demographically matched healthy controls using samples collected every 3 hours over 24 hours and assessed with radioimmunoassay (RIA). The abstinent heroin-dependent participants had significantly higher plasma cortisol levels nocturnally suggesting a loss of diurnal variation in these heroin subjects.
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