期刊
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
卷 34, 期 1, 页码 109-121出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/00952990701764821
关键词
abstinence; attention; cocaine; cognition; memory; performance
资金
- NCRR NIH HHS [K12RR17594, M01-RR00125] Funding Source: Medline
- NIDA NIH HHS [R01 DA011744, R01DA11744, K02 DA00397] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000125, K12RR017594] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [K02DA000397, R01DA011744] Funding Source: NIH RePORTER
Seventeen non-treatment seeking cocaine-dependent individuals participated in three-week longitudinal inpatient studies of cognitive changes during drug use and abstinence. Protocols included three days drug-free baseline, three days cocaine self-administration, and two weeks complete abstinence. A repeatable cognitive battery showed attention and delayed verbal recognition memory but not working memory to be impaired in cocaine users compared to age- and sex-matched normative values. Attention was significantly poorer during the first and second week of abstinence compared to days on which cocaine was used suggesting that certain cocaine-induced impairments may be acutely normalized by cocaine use, but resurface during abstinence.
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