Article
Pharmacology & Pharmacy
Ilaria Ottonelli, Jason Thomas Duskey, Arianna Rinaldi, Maria Vittoria Grazioli, Irene Parmeggiani, Maria Angela Vandelli, Leon Z. Wang, Robert K. Prud'homme, Giovanni Tosi, Barbara Ruozi
Summary: This study aimed to transfer the production protocol for hybrid NMeds (H-NMeds) from a benchtop nanoprecipitation method to a microfluidic device, showing that microfluidic technology is not a simple transfer of established parameters, with several variables to be taken into account and optimized.
Article
Chemistry, Physical
Voitto Kankanen, Micaela Fernandes, Zehua Liu, Jani Seitsonen, Sami-Pekka Hirvonen, Janne Ruokolainen, Joao F. Pinto, Jouni Hirvonen, Vimalkumar Balasubramanian, Helder A. Santos
Summary: This study reports the development of poly(ethylene glycol)-block-(e-caprolactone) (PEG-b-PCL) nanoparticles using a microfluidic technique for intravenous drug delivery. The optimized formulation achieved spherical morphology, small particle size (dH < 80 nm), uniform size distribution (PDI < 0.2), high drug loading degree (16%), and encapsulation efficiency of 54%. Furthermore, the nanoparticles exhibited stability and sustained release of sorafenib in vitro over several days. Overall, this research demonstrates the use of microfluidic approach in optimizing drug delivery systems.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Mahmoud Abdelkarim, Noura H. Abd Ellah, Mahmoud Elsabahy, Mohamed Abdelgawad, Sara A. Abouelmagd
Summary: This study explored the effect of channel geometry and design on poly (lactic-co-glycolic) acid (PLGA) NPs size and polydispersity index (PDI). It was found that changing channel length did not have a significant impact on particle size, but increasing diffusion area and reducing mixing time significantly reduced particle size. Introduction of channel curvature enhanced mixing and decreased particle size dependent on the velocity of the generated Dean flow.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Multidisciplinary
Hyeonwoo Han, Jeong Hoon Yoon, Gi-Ra Yi, Won Il Choi, Jong-Min Lim
Summary: Research on continuous synthesis of polymeric nanoparticles was conducted, and a self-aligned coaxial turbulent jet mixer was developed for high-speed continuous synthesis. Using this mixer with polystyrene solution, uniform polymeric NPs can be continuously synthesized and their dispersion stability in aqueous solution can be improved.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Jitkasem Meewan, Sukrut Somani, Jamal Almowalad, Partha Laskar, Margaret Mullin, Graeme MacKenzie, Swapnil Khadke, Yvonne Perrie, Christine Dufes
Summary: This study evaluated the production of zein nanoparticles using a microfluidic system and found that adjusting the PEG density and chain length improved the stability and drug uptake of the nanoparticles.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Materials Science, Multidisciplinary
William N. Sharratt, Victoria E. Lee, Rodney D. Priestley, Joao T. Cabral
Summary: This review compares two versatile approaches for the precise formation of polymer particles: flash nanoprecipitation (FNP) and droplet solvent extraction (DSE). FNP generates nanoparticles with diameters ranging from 10-1000 nm, while DSE produces particles with diameters from 1-1000 µm. Both methods involve a series of processes leading to a variety of internal and external particle morphologies.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Polymer Science
Ewa Rybak, Piotr Kowalczyk, Sylwia Czarnocka-Sniadala, Michal Wojasinski, Jakub Trzcinski, Tomasz Ciach
Summary: The nanoprecipitation method was used to successfully formulate fluorescent PCL nanoparticles with small average diameter and low polydispersity index. In vitro experiments showed controlled dye release from these nanoparticles. Furthermore, MTT assays confirmed the non-toxicity of the PCL nanoparticles to cells. Thus, PCL nanoparticles have the potential for developing new drug delivery systems.
Article
Chemistry, Medicinal
Gomathi Mahadevan, Suresh Valiyaveettil
Summary: High concentrations of micro- and nanoparticles of common plastic materials in the environment are having adverse health impacts on living organisms. The synthesized luminescent PVC and PMMA nanoparticles were shown to enter cells through endocytosis, leading to reduced cell viability and other cytotoxic effects. This study provides important insights into the effects of polymer nanoparticles on human health.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Article
Biochemical Research Methods
Peer Erfle, Juliane Riewe, Heike Bunjes, Andreas Dietzel
Summary: The coaxial lamination mixer (CLM) enables efficient production of stable, scalable lipid nanoparticles loaded with poorly soluble drugs, ensuring high throughput parallelization.
Article
Chemistry, Applied
Salma M. Abdel-Hafez, Josef Zapp, Markus Gallei, Marc Schneider
Summary: This study selected maltodextrin (MD) as the material for producing nanoparticles due to its economic, non-toxic, biocompatible, and biodegradable properties. The MDs were modified through acetal modification, resulting in hydrophobic polymers with pH-dependent degradability. The synthesized acetalated MD (AcMD) polymers exhibited different thermal properties and lower glass transition temperatures. Uniform AcMD nanoparticles (NPs) with diameters ranging from 141 to 258 nm were produced through nanoprecipitation. These particles were loaded with a hydrophobic model drug, resveratrol, and showed high entrapment efficiency and drug loading. The degradation and release behavior of the particles were studied under different pH conditions, and their interaction with different cell lines was also investigated.
CARBOHYDRATE POLYMERS
(2022)
Review
Chemistry, Multidisciplinary
Joao P. F. Carvalho, Ana C. Q. Silva, Armando J. D. Silvestre, Carmen S. R. Freire, Carla Vilela
Summary: The article presents the preparation and application fields of cellulose micro and nanoparticles, emphasizing the widespread use of cellulose in the preparation of various materials, and pointing out that the research in this field has been steadily increasing year by year.
Article
Biophysics
Marek Brzezinski, Marta Socka, Tomasz Makowski, Bartlomiej Kost, Marcin Cieslak, Karolina Krolewska-Golinska
Summary: This study developed a novel microfluidic approach for preparing (co)polymeric and hybrid nanoparticles, which showed great potential in drug release and inhibition of breast cancer cells. The composition of PCL/TA NPs demonstrated the most efficient antitumor activity among all formulations, surpassing the efficacy of free DOX.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Joseph Rosenfeld, Francois Ganachaud, Daeyeon Lee
Summary: Flow-based nanoprecipitation, which involves rapid mixing of two miscible liquids, is a scalable strategy for manufacturing nanoparticles with various shapes and morphologies. However, controlling the size of nanoparticles in this process is often done through empirical variations in flow rate ratios or total flow rate. In this study, coprecipitation of oil and polymer to form nanocapsules was investigated using glass capillary microfluidics, revealing the importance of supersaturation in determining the average diameter of the fabricated capsules. The control over nanocapsule size by varying the extent of supersaturation provides a systematic approach to controlling the size of nanoparticles via continuous nanoprecipitation.
Article
Chemistry, Applied
Hongmin Dong, Qing Zhang, Jun Gao, Lingyun Chen, Thava Vasanthan
Summary: The study investigated methods for producing starch nanoparticles under different processing parameters and analyzed their properties. Batch nanoprecipitation (BNP) can achieve smaller particle size and narrower size distribution in a shorter time. Under optimized conditions, continuous methods (such as flash nanoprecipitation) can be potential for commercial scale-up production.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Multidisciplinary
Preena Shrimal, Girirajsinh Jadeja, Sanjaykumar Patel
Summary: The study focused on utilizing a continuous microfluidic nanoprecipitation process to prepare nanosized particles of telmisartan, a poorly water-soluble drug, and enhancing its solubility and bioavailability. Various polymers were investigated to control the surface forces between the particles, with Poloxamer 407 identified as the most effective polymer in minimizing drug agglomeration and producing nanoparticles with the smallest particle size and polydispersity index.
