Use of Angiogenic Factors (sFlt-1/PlGF Ratio) to Confirm the Diagnosis of Preeclampsia in Clinical Routine: First Experience

Introduction: In the clinical routine, the diagnosis of preeclampsia is often challenging. Not all pregnant women with signs and symptoms of preeclampsia develop the disease. Recently, the assessment of the sFlt-1/PlGF ratio in the serum of pregnant women has been proposed as an aid in the diagnosis of preeclampsia. Patients and Methods: In a retrospective, monocentric case-control study, we reviewed 30 cases of patients who presented with the clinical symptoms of hypertensive disorders of pregnancy in the delivery ward. Next to the standard diagnostic algorithm for preeclampsia, the sFlt-1/PlGF ratio was determined using the automated Elecsys (R) platform. Results: In 12/30 cases (40 %), the diagnosis of a hypertensive pregnancy disorder was confirmed with an sFlt1/PlGF ratio of >85. In 18/30 (60 %) cases, a ratio <85 excluded the diagnosis of preeclampsia at the time of presentation and allowed an adaptation of the patient's surveillance programme. Conclusion: In the clinical setting of suspected preeclampsia, determination of the sFlt-1/PlGF ratio can serve as an aid in the diagnosis of hypertensive disorders in pregnancy. The reliable exclusion of the diagnosis preeclampsia can help in an appropriate and cost-effective management of patients with signs and symptoms of the disease.