期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 11, 期 -, 页码 1-6出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.11.4
关键词
antibacterial; combinatorial; diynes; homodimerization; multicomponent reactions; peptoids; Ugi reaction
资金
- State of Saxony-Anhalt (MK-LSA, Projekt Lipopeptide)
- Brazilian National Research Council (CNPq)
- Studienstiftung des Deutschen Volkes
A library of ten 1,3-diyne-linked peptoids has been synthesized through an Ugi four-component reaction (U-4CR) followed by a copper-catalysed alkyne homocoupling (Glaser reaction). The short and chemoselective reaction sequence allows generating diverse (pseudo) dimeric peptoids. A combinatorial version allows the one-pot preparation of, e.g., six-compound-libraries of homo- and heterodimers verified by ESI-MS and HPLC. In a preliminary evaluation, some compounds display moderate activity against the Gram-positive bacterium Bacillus subtilis.
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