7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription

The super elongation complex (SEC) and MLL in development and disease

(2011) E. Smith et al.   GENES & DEVELOPMENT

Conserved and divergent features of the structure and function of La and La-related proteins (LARPs)

(2010) Mark A. Bayfield et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

c-Myc Regulates Transcriptional Pause Release

(2010) Peter B. Rahl et al.   CELL

Pausing of RNA Polymerase II Disrupts DNA-Specified Nucleosome Organization to Enable Precise Gene Regulation

(2010) Daniel A. Gilchrist et al.   CELL

Camptothecin releases P-TEFb from the inactive 7SK snRNP complex

(2010) Stefano Amente et al.   CELL CYCLE

Transcription elongation takes central stage: The P-TEFb connection

(2010) B. Matija Peterlin   CELL CYCLE

CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1

(2010) B. Bartkowiak et al.   GENES & DEVELOPMENT

Nuclear Organization and Dynamics of 7SK RNA in Regulating Gene Expression

(2010) Kannanganattu V. Prasanth et al.   MOLECULAR BIOLOGY OF THE CELL

AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia

(2010) Chengqi Lin et al.   MOLECULAR CELL

HIV-1 Tat Assembles a Multifunctional Transcription Elongation Complex and Stably Associates with the 7SK snRNP

(2010) Bijan Sobhian et al.   MOLECULAR CELL

Crystal structure of HIV-1 Tat complexed with human P-TEFb

(2010) Tahir H. Tahirov et al.   NATURE

RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation

(2010) Iván D'Orso et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HEXIM1 targets a repeated GAUC motif in the riboregulator of transcription 7SK and promotes base pair rearrangements

(2010) Isabelle Lebars et al.   NUCLEIC ACIDS RESEARCH

The Mechanism of Release of P-TEFb and HEXIM1 from the 7SK snRNP by Viral and Cellular Activators Includes a Conformational Change in 7SK

(2010) Brian J. Krueger et al.   PLoS One

7SK RNA, a non-coding RNA regulating P-TEFb, a general transcription factor

(2010) Gaelle Diribarne et al.   RNA Biology

Controlling Cellular P-TEFb Activity by the HIV-1 Transcriptional Transactivator Tat

(2010) Lisa Muniz et al.   PLoS Pathogens

Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells

(2009) Sungyoo Cho et al.   EMBO JOURNAL

Suberoylanilide Hydroxamic Acid Reactivates HIV from Latently Infected Cells

(2009) Xavier Contreras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

U30 of 7SK RNA Forms a Specific Photo-cross-link with Hexim1 in the Context of Both a Minimal RNA-binding site and a Fully Reconstituted 7SK/Hexim1/P-TEFb Ribonucleoprotein Complex

(2009) François Bélanger et al.   JOURNAL OF MOLECULAR BIOLOGY

Evolution of 7SK RNA and Its Protein Partners in Metazoa

(2009) M. Marz et al.   MOLECULAR BIOLOGY AND EVOLUTION

A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP

(2009) Y. Xue et al.   NUCLEIC ACIDS RESEARCH

7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development

(2009) M. Barboric et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Misguided Transcriptional Elongation Causes Mixed Lineage Leukemia

(2009) Dorothee Mueller et al.   PLOS BIOLOGY

miR-198 Inhibits HIV-1 Gene Expression and Replication in Monocytes and Its Mechanism of Action Appears To Involve Repression of Cyclin T1

(2009) Tzu-Ling Sung et al.   PLoS Pathogens

PP2B and PP1  cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling

(2008) R. Chen et al.   GENES & DEVELOPMENT

Inhibition of Transcription by the Caenorhabditis elegans Germline Protein PIE-1: Genetic Evidence for Distinct Mechanisms Targeting Initiation and Elongation

(2008) Dolan Ghosh et al.   GENETICS

Gene expression in early stage cervical cancer

(2008) Petra Biewenga et al.   GYNECOLOGIC ONCOLOGY

Invertebrate 7SK snRNAs

(2008) Andreas R. Gruber et al.   JOURNAL OF MOLECULAR EVOLUTION

A La-Related Protein Modulates 7SK snRNP Integrity to Suppress P-TEFb-Dependent Transcriptional Elongation and Tumorigenesis

(2008) Nanhai He et al.   MOLECULAR CELL

Structural insights into the Cyclin T1–Tat–TAR RNA transcription activation complex from EIAV

(2008) Kanchan Anand et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated

(2008) B. J. Krueger et al.   NUCLEIC ACIDS RESEARCH

HDAC6: a key regulator of cytoskeleton, cell migration and cell–cell interactions

(2008) Agustín Valenzuela-Fernández et al.   TRENDS IN CELL BIOLOGY