Review
Immunology
James W. Reinhardt, Christopher K. Breuer
Summary: This review details past studies on fibrocytes, their findings, and discusses their strengths and limitations, aiming to identify opportunities for further investigation and promote best practices in future study design.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zhengxia Wang, Wei Liu, Huidi Hu, Jingxian Jiang, Chen Yang, Xijie Zhang, Qi Yuan, Xiaofan Yang, Mao Huang, Yanming Bao, Ningfei Ji, Mingshun Zhang
Summary: This study found that decreased expression of CD146 in pulmonary tissues is associated with increased inflammatory response in pulmonary cryptococcosis. Furthermore, CD146 deficiency worsens the infection by C. neoformans.
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2023)
Article
Clinical Neurology
Conelius Ngwa, Abdullah Al Mamun, Shaohua Qi, Romana Sharmeen, Maria P. Blasco Conesa, Bhanu P. Ganesh, Bharti Manwani, Fudong Liu
Summary: This study investigated the role of interferon regulatory factor 4 (IRF4) and IRF5 in microglia and monocytes in cerebral ischemia. The findings suggest that the central IRF4/5 signaling pathway plays a critical role in cerebral ischemia and can affect microglial activation and stroke outcomes.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Geriatrics & Gerontology
Jingwen Tian, Hyo Kyun Chung, Ji Sun Moon, Ha Thi Nga, Ho Yeop Lee, Jung Tae Kim, Joon Young Chang, Seul Gi Kang, Dongryeol Ryu, Xiangguo Che, Je-Yong Choi, Masayuki Tsukasaki, Takayoshi Sasako, Sang-Hee Lee, Minho Shong, Hyon-Seung Yi
Summary: Defects in muscle mitochondrial OxPhos promote bone marrow inflammation in mice, leading to decreased bone mass. Muscle mitochondrial dysfunction is linked to bone marrow inflammatory cytokine secretion via the CXCL12-CXCR4 signaling axis, which is critical for inducing low bone mass.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Review
Endocrinology & Metabolism
Nicole Aaron, Samantha Costa, Clifford J. Rosen, Li Qiang
Summary: BMAT is now recognized as a metabolically active organ that plays versatile roles in endocrine function, hematopoiesis, bone homeostasis, and metabolism. Age-related inflammatory changes associated with BMAT accrual and the downstream effect on endocrine function, energy expenditure, and metabolism are discussed, with potential therapeutic strategies addressed to prevent dysfunction during aging. Further research is needed to fully understand the explicit characterization of BMAT in aging.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Christina Kassiteridi, Jennifer E. Cole, Thibault Griseri, Mika Falck-Hansen, Michael E. Goddard, Anusha N. Seneviratne, Patricia A. Green, Inhye Park, Annelie G. Shami, Tanyaporn Pattarabanjird, Aditi Upadhye, Angela M. Taylor, Ashok Handa, Keith M. Channon, Esther Lutgens, Coleen A. McNamara, Richard O. Williams, Claudia Monaco
Summary: The study demonstrates the significant role of CD200 in atherosclerosis, where CD200 deficiency increases atherosclerotic lesion formation. The CD200/CD200R pathway restrains macrophage activation and monocyte recruitment, limiting the progression of atherosclerosis.
CIRCULATION RESEARCH
(2021)
Review
Clinical Neurology
Zili Wang, Xudong Wang, Yidong Liao, Guangtang Chen, Kaya Xu
Summary: Stroke is a major cause of death and disability worldwide, and current treatment options are limited. Bone marrow mesenchymal stromal cells (BMSCs) offer a new approach for stroke treatment, but research on the precise inflammatory mechanism is lacking. In this review, we summarize the immune response of BMSCs in stroke treatment and provide a new perspective for stem cell therapy.
FRONTIERS IN NEUROLOGY
(2022)
Article
Hematology
Joseph H. Oved, Andrew J. Paris, Kandace Gollomp, Ning Dai, Kathryn Rubey, Ping Wang, Lynn A. Spruce, Steven H. Seeholzer, Mortimer Poncz, G. Scott Worthen
Summary: Neutrophils play a critical role in sterile inflammation, engulfing and degrading extracellular DNA fragments to facilitate optimal organ repair.
Article
Biochemistry & Molecular Biology
Jasmine Nour, Annalisa Moregola, Monika Svecla, Lorenzo Da Dalt, Rossella Bellini, Olivier Neyrolles, Gian Paolo Fadini, Yoann Rombouts, Mattia Albiero, Fabrizia Bonacina, Giuseppe Danilo Norata
Summary: Research has shown that during a high-fat diet, deficiency of the mannose receptor affects bone marrow and circulating immune cell subsets, leading to reduced systemic inflammation and resistance to obesity development.
Review
Immunology
Elsa Bourayou, Rachel Golub
Summary: NK cells are innate lymphocytes that play a crucial role in immune defense and cancer therapy. Their development in the bone marrow and migration to peripheral organs are regulated by key factors and influenced by inflammatory contexts. This review summarizes the stages of NK cell development and discusses newly discovered factors involved in their maturation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Meike Farber, Yiyang Chen, Lucas Arnold, Michael Moellmann, Eva Boog-Whiteside, Yu-An Lin, H. Christian Reinhardt, Ulrich Duehrsen, Maher Hanoun
Summary: Targeting the interaction between leukemic cells and the microenvironment by inhibiting CD38 has the potential to enhance therapeutic efficacy in AML. However, while the anti-CD38 antibody daratumumab showed significant cytostatic efficacy in an in vitro model, it ultimately lacked robust anti-leukemic effects in vivo in a xenograft transplantation model.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Nicole Pui-Yu Ho, Hitoshi Takizawa
Summary: This article summarizes the current understanding of how hematopoietic stem cell functions are maintained, damaged, or exhausted during acute, prolonged, and pathological inflammatory conditions. It also highlights the impact of inflammation-altered hematopoietic stem cell niche on escalating the insults on hematopoietic stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Wei Ying, Kechun Tang, Ennio Avolio, Jan M. Schilling, Teresa Pasqua, Matthew A. Liu, Hongqiang Cheng, Hong Gao, Jing Zhang, Sumana Mahata, Myung S. Ko, Gautam Bandyopadhyay, Soumita Das, David M. Roth, Debashis Sahoo, Nicholas J. G. Webster, Farah Sheikh, Gourisankar Ghosh, Hemal H. Patel, Pradipta Ghosh, Geert van den Bogaart, Sushil K. Mahata
Summary: The study demonstrates that CST plays a key role in attenuating cardiac inflammation in hypertension by reducing macrophage inflammation to alleviate disease symptoms.
Article
Oncology
Chuling Fang, Andrew E. Rinke, Jing Wang, Kevin R. Flaherty, Sem H. Phan, Tianju Liu
Summary: Elevated levels of sB7H3 and B7H3(+) cells in blood samples of IPF patients were found to be negatively correlated with lung function decline. sB7H3 was shown to induce the influx of MDSCs into lung tissue and enhance inflammation, as well as cause the accumulation of MDSCs in the bone marrow.
JOURNAL OF PATHOLOGY
(2022)
Review
Immunology
Jun Wang, Miriam Erlacher, Juncal Fernandez-Orth
Summary: Under inflammatory conditions, steady-state hematopoiesis switches to emergency myelopoiesis, leading to different forms of cell death and other changes in the hematopoietic system, ultimately causing loss of hematopoiesis function. In individuals with inherited bone marrow failure syndromes or immune-mediated aplastic anemia, chronic inflammatory signals may aggravate disease progression.
FRONTIERS IN IMMUNOLOGY
(2022)
