Article
Multidisciplinary Sciences
Zhensen Chen, Anders Gould, Duygu Baylam Geleri, Niranjan Balu, Li Chen, Baocheng Chu, Kristi Pimentel, Gador Canton, Thomas S. Hatsukami, Chun Yuan
Summary: The study aimed to explore the associations between intracranial vascular features extracted from NCE-MRA images and global cognition. The results showed that artery length and number of branches were positively associated with cognitive scores. These findings suggest that intracranial vascular features may serve as useful markers of cerebrovascular health and provide additional information in individuals with cognitive impairment.
SCIENTIFIC REPORTS
(2022)
Article
Anesthesiology
Swarna Rajagopalan, Jovany Cruz Navarro, Sanam Baghshomali, Matthew Kirschen, David Greer, W. Andrew Kofke, Ramani Balu
Summary: This study retrospectively observed the changes in cerebrovascular physiology and neurochemistry during brain death, finding that brain tissue undergoes significant alterations during brain death, which can be monitored and analyzed through intracranial neuromonitoring.
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2021)
Article
Neurosciences
Ken-ichi Iwasaki, Yojiro Ogawa, Takuya Kurazumi, Syed M. Imaduddin, Chiaki Mukai, Satoshi Furukawa, Ryo Yanagida, Tomokazu Kato, Toru Konishi, Ari Shinojima, Benjamin D. Levine, Thomas Heldt
Summary: The study found that in the majority of astronauts (>90%), long-duration spaceflight did not lead to an increase in postflight intracranial pressure, suggesting that the fluid shift during spaceflight does not systematically elevate ICP. For astronauts with ocular alterations, both increases and decreases in intracranial pressure were observed post-flight, indicating a lack of primary causal relationship between elevated ICP and spaceflight associated optical changes. Independently of ICP and ocular alterations, the results suggest that long-duration spaceflight may increase cerebral blood flow, possibly due to reduced haemoglobin concentration.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Computer Science, Interdisciplinary Applications
Juanjo Perez-Sanchez, Juan M. Carrillo de Gea, Sandra Rodriguez Barcelo, Angel Toval, Jose L. Fernandez-Aleman, Jose A. Garcia-Berna, Miroljub Popovic, Ambrosio Toval
Summary: ICP monitoring and analysis techniques are widely applied each year, with the detection of A and B-waves and analysis of C-waves in the ICP waveform indicating decreased intracranial compliance. Despite advances in automated data analysis, visual screening remains the primary means of detecting these waves. This study identified several gaps in research and highlighted the need for new analysis methods in ICP automated analysis.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Multidisciplinary Sciences
Motoki Fujita, Yasutaka Oda, Kotaro Kaneda, Tadashi Kaneko, Eiichi Suehiro, Kenji Dohi, Yasuhiro Kuroda, Hitoshi Kobata, Ryosuke Tsuruta, Tsuyoshi Maekawa
Summary: This study aimed to investigate the association between the temperature difference between the jugular bulb and pulmonary artery (Delta Tjb-pa) and the neurological outcome of patients with severe traumatic brain injury (TBI). The results showed that a reduction in Delta Tjb-pa and greater variation in Delta Tjb-pa were associated with an unfavorable outcome, especially in patients treated with mild therapeutic hypothermia (TH).
Article
Biochemistry & Molecular Biology
Philippe Garrigue, Lourdes Mounien, Serge Champion, Yassin Mouhajir, Laurent Pechere, Benjamin Guillet, Jean-Francois Landrier, Eric Seree
Summary: With aging, there is a higher incidence of coincident cerebrovascular deficiency and cognitive dysfunction. Resveratrol, a natural phytoalexin, is believed to have protective effects on cerebral vascularization and cognitive function associated with aging. Additionally, long-term treatment with Resveratrol was found to improve cognitive performance in elderly male rats by increasing cerebral blood flow and reducing pro-inflammatory pathways in the brain.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Neurosciences
Guangshan Hao, Catharina Conzen-Dilger, Tobias Philip Schmidt, Ekaterina Harder, Malte Schoeps, Johanna Charlotte Clauser, Gerrit Alexander Schubert, Ute Lindauer
Summary: This study established a rat model of intracranial hypertension, which mimicked the course of intracranial pressure (ICP) in the first 6 hours following subarachnoid hemorrhage (SAH). The results showed that blood components play a more significant role in early hypoperfusion events than elevated ICP.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Peripheral Vascular Disease
Justine E. Moonen, Behnam Sabayan, Sigurdur Sigurdsson, Mark A. van Buchem, Vilmundur Gudnason, Osorio Meirelles, Lenore J. Launer
Summary: Late-life diastolic blood pressure was negatively associated with cerebral blood flow, while late-life systolic blood pressure and pulse pressure were positively associated. Higher cerebral blood flow was related to better cognitive performance and lower risk of mild cognitive impairment or dementia.
Article
Surgery
Hossam Abdou, Joseph Edwards, Neerav Patel, David P. Stonko, Noha Elansary, Eric Lang, Michael J. Richmond, Thomas Ptak, Joseph M. White, Thomas M. Scalea, Jonathan J. Morrison
Summary: This study successfully established a titratable intracranial pressure model by using a Fogarty balloon catheter to increase intracranial pressure in an animal model, and measured the resulting decrease in brain perfusion.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Obstetrics & Gynecology
Lina Bergman, Catherine Cluver, Niclas Carlberg, Michael Belfort, Mary C. Tolcher, Ronney B. Panerai, Teelkien van Veen
Summary: Dynamic cerebral autoregulation and cerebral perfusion pressure are altered in pregnancies complicated by preeclampsia, which may be important in the pathophysiological pathway and constitute a therapeutic target in the prevention of cerebral complications in preeclampsia.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Biophysics
Arkadiusz Ziolkowski, Agata Pudelko, Agnieszka Kazimierska, Zofia Czosnyka, Marek Czosnyka, Magdalena Kasprowicz
Summary: The study examined the utility of the ratio of pulse slopes (RPS) in assessing intracranial compliance. Findings showed changes in RPS and ICP pulse morphology during infusion tests, with a significant correlation between baseline RPS and intracranial elasticity.
PHYSIOLOGICAL MEASUREMENT
(2021)
Article
Clinical Neurology
Syeda Tabassum, Alexander Ruesch, Deepshikha Acharya, Jason Yang, Filip A. J. Relander, Bradley Scammon, Michael S. Wolf, Jaskaran Rakkar, Robert S. B. Clark, Michael M. McDowell, Jana M. Kainerstorfer
Summary: The authors developed a noninvasive method to monitor intracranial pressure (ICP) by using blood flow measurement and a machine learning model. The estimated ICP closely matched the invasive ICP, showing the potential of this low-risk monitoring method. It can expand the indications for ICP monitoring and reduce the use of invasive monitors.
JOURNAL OF NEUROSURGERY
(2023)
Review
Endocrinology & Metabolism
Claudia A. Smith, Keri L. H. Carpenter, Peter J. Hutchinson, Peter Smielewski, Adel Helmy
Summary: The loss of cerebral autoregulation (CA) is a common and detrimental secondary injury mechanism following acute brain injury. Neuroinflammation, particularly inflammation affecting the cerebral vasculature, could be a putative mechanism that causes CA dysfunction. This review provides an overview of CA, its impairment following brain injury, and discusses potential mechanisms and markers related to disturbance of the cerebral blood flow and autoregulation.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Samuel P. Klein, Veerle De Sloovere, Geert Meyfroidt, Bart Depreitere
Summary: This study provides new insights into the quadriphasic physiology of cerebrovascular autoregulation (CA) and reveals substantial intersubject variability in the limits of CA.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Endocrinology & Metabolism
Zhao Liming, Sun Weiliang, Jia Jia, Liang Hao, Liu Yang, Christopher Ludtka, Behnam Rezai Jahromi, Felix Goehre, Ajmal Zemmar, Li Tianxiao, Juha Hernesniemi, Hugo Andrade-Barazarte, Li Chaoyue
Summary: The impact of targeted blood pressure modifications on cerebral blood flow in ischemic moyamoya disease patients was investigated through single-photon emission computed tomography (SPECT) in a study involving 40 patients. The study found that cerebral blood flow in moyamoya disease patients is susceptible to small blood pressure changes and cerebral autoregulation might be affected due to short dynamic blood pressure modifications.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Multidisciplinary Sciences
Kumar Vaibhav, Molly Braun, Katelyn Alverson, Hesam Khodadadi, Ammar Kutiyanawalla, Ayobami Ward, Christopher Banerjee, Tyler Sparks, Aneeq Malik, Mohammad H. Rashid, Mohammad Badruzzaman Khan, Michael F. Waters, David C. Hesss, Ali S. Arbab, John R. Vender, Nasrul Hoda, Babak Baban, Krishnan M. Dhandapani
Article
Medicine, Research & Experimental
Babak Baban, Molly Braun, Hesam Khodadadi, Ayobami Ward, Katelyn Alverson, Aneeq Malik, Khoi Nguyen, Skon Nazarian, David C. Hess, Scott Forseen, Alexander F. Post, Fernando L. Vale, John R. Vender, Md Nasrul Hoda, Omid Akbari, Kumar Vaibhav, Krishnan M. Dhandapani
Summary: The study shows increased proliferation of ILCs within the meninges after acute brain injury, with higher levels in TBI patients. AMPK plays a role in inhibiting ILC expansion, while IL-33 administration activates AMPK and suppresses specific ILC types.
Article
Neurosciences
Hesam Khodadadi, Evila Lopes Salles, Abbas Jarrahi, Vincenzo Costigliola, M. B. Khan, Jack C. Yu, John C. Morgan, David C. Hess, Kumar Vaibhav, Krishnan M. Dhandapani, Babak Baban
Summary: Our study found that CBD treatment enhanced the expression of IL-33 and TREM2, ameliorated AD symptoms, and slowed down cognitive decline in a translational model of familial AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Nanoscience & Nanotechnology
Ahmet Alptekin, Mohammad B. Khan, Roxan Ara, Mohammad H. Rashid, Fengchong Kong, Mahrima Parvin, Joseph A. Frank, Rajiv Chopra, Krishnan Dhandapani, Ali S. Arbab
Summary: Exosomes have been shown to carry important biomolecules and can be delivered to stroke areas using pulsed focused ultrasound, but the administration of nanobubbles has detrimental effects on brain structures.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jing Wang, Quanguang Zhang, Yujiao Lu, Yan Dong, Krishnan M. Dhandapani, Darrell W. Brann, Robert K. Yu
Summary: The study demonstrates that ganglioside GD3 regulates phagocytosis by microglia in an ischemic stroke model. The impaired phagocytic capacity of GD3S-KO microglia after GCI may contribute to delayed neuronal death.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Cell Biology
Babak Baban, Hesam Khodadadi, Evila Lopes Salles, Vincenzo Costigliola, John C. Morgan, David C. Hess, Kumar Vaibhav, Krishnan M. Dhandapani, Jack C. Yu
Summary: Aging is a complex phenomenon that affects all parts of an animal's body and physiology, with the immune system playing a crucial role in responding to injury and defending against pathogens. The reciprocal relationship between immune aging and inflammaging has led to the suggestion that phytocannabinoids may have the potential to slow down aging as effective adjunctive therapies.
AGEING RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Meenakshi Ahluwalia, Manish Kumar, Pankaj Ahluwalia, Scott Rahimi, John R. Vender, Raghavan P. Raju, David C. Hess, Babak Baban, Fernando L. Vale, Krishnan M. Dhandapani, Kumar Vaibhav
Summary: Mitochondria play multiple roles in cellular energy production, survival, neuropathologies, and neurodegeneration. Dysfunction of mitochondria, involving oxidative stress, inflammation, and deficits in bioenergetics, is associated with brain injury and intracerebral hemorrhages, highlighting the importance of developing targeted therapeutics to protect mitochondria for improved functional outcomes.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Yujiao Lu, Jing Wang, Fulei Tang, Uday P. Pratap, Gangadhara R. Sareddy, Krishnan M. Dhandapani, Ana Capuano, Zoe Arvanitakis, Ratna K. Vadlamudi, Darrell W. Brann
Summary: Hemoglobin plays an important role in regulating neuronal oxygenation and neuroprotection. The levels of neuronal hemoglobin decrease with age in mice, leading to increased hypoxia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Patrick D. Lyden, Francesca Bosetti, Marcio A. Diniz, Andre Rogatko, James Koenig, Jessica Lamb, Karisma A. Nagarkatti, Ryan P. Cabeen, David C. Hess, Pradip K. Kamat, Mohammad B. Khan, Kristofer Wood, Krishnan Dhandapani, Ali S. Arbab, Enrique C. Leira, Anil K. Chauhan, Nirav Dhanesha, Rakesh B. Patel, Mariia Kumskova, Daniel Thedens, Andreia Morais, Takahiko Imai, Tao Qin, Cenk Ayata, Ligia S. B. Boisserand, Alison L. Herman, Hannah E. Beatty, Sofia E. Velazquez, Sebastian Diaz-Perez, Basavaraju G. Sanganahalli, Jelena M. Mihailovic, Fahmeed Hyder, Lauren H. Sansing, Raymond C. Koehler, Steven Lannon, Yanrong Shi, Senthilkumar S. Karuppagounder, Adnan Bibic, Kazi Akhter, Jaroslaw Aronowski, Louise D. McCullough, Anjali Chauhan, Andrew Goh
Summary: Cerebral ischemia and reperfusion lead to neurological disabilities, and developing successful stroke treatments has been challenging. The Stroke Preclinical Assessment Network (SPAN) aims to reduce bias in treatment selection for clinical studies by rigorously assessing candidate treatments across multiple research laboratories. The first stage of SPAN successfully implemented standardized procedures, randomization, and blinded assessment. Subsequent stages will evaluate candidate treatments using aged animals and animals with comorbid conditions.
Article
Neurosciences
Abbas Jarrahi, Manan Shah, Meenakshi Ahluwalia, Hesam Khodadadi, Kumar Vaibhav, Askiel Bruno, Babak Baban, David C. Hess, Krishnan M. Dhandapani, John R. Vender
Summary: This study explores the role of remote ischemic conditioning (RIC) in promoting hematoma resolution and improving outcomes in patients with intracerebral hemorrhage (ICH). The study will conduct a pilot trial to evaluate the safety and efficacy of RIC compared to mock conditioning in ICH patients, and also include exploratory genomic analysis. The goal of this study is to establish a foundation for future larger, multi-center clinical trials.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Pradip K. Kamat, Mohammad Badruzzaman Khan, Cameron Smith, Shahneela Siddiqui, Babak Baban, Krishnan Dhandapani, David C. Hess
Summary: The circadian system, controlled by clock genes, plays an important role in stroke outcomes. The circadian clock is present in the brain's suprachiasmatic nucleus and operates through molecular circadian clocks in neurons and other brain cells. Variations in the circadian cycle and clock genes can affect stroke occurrence and severity, with peak stroke occurring in the morning and worsening outcomes at midnight. Sleep blood pressure, influenced by the circadian rhythm, is a primary determinant of stroke risk.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Neurosciences
Meenakshi Ahluwalia, Hannah Mcmichael, Manish Kumar, Mario P. Espinosa, Asamoah Bosomtwi, Yujiao Lu, Hesam Khodadadi, Abbas Jarrahi, Mohammad Badruzzaman Khan, David C. Hess, Scott Y. Rahimi, John R. Vender, Fernando L. Vale, Molly Braun, Babak Baban, Krishnan M. Dhandapani, Kumar Vaibhav
Summary: In this study, the authors found that traumatic brain injury leads to a loss of endocannabinoids, exacerbating neurovascular injury, compromising brain-cerebrospinal fluid barriers, and causing behavioral dysfunction. They also observed increased expression of endocannabinoid-metabolizing enzymes and CB2 receptors, as well as a reduction in cerebral blood flow in post-TBI mice. These findings highlight the importance of endocannabinoids in maintaining brain and brain-cerebrospinal fluid barrier integrity.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Hesam Khodadadi, Evila Lopes Salles, Eunice Shin, Abbas Jarrahi, Vincenzo Costigliola, Pritesh Kumar, Jack C. Yu, John C. Morgan, David C. Hess, Kumar Vaibhav, Krishnan M. Dhandapani, Babak Baban
Summary: The study suggests that cannabichromene (CBC) delivered through inhalation might be an effective alternative therapeutic target for the treatment of acute respiratory distress syndrome (ARDS). Furthermore, increased expression of transient receptor potential (TRP) cation channels after CBC treatment proposes a new potential mechanism for the beneficial effects of CBC and other cannabinoids in treating ARDS and other inflammatory diseases. Importantly, using an inhaler device to deliver CBC supports the feasibility of human trials and warrants further research.
JOURNAL OF CANNABIS RESEARCH
(2021)
Review
Medicine, General & Internal
Pankaj Ahluwalia, Meenakshi Ahluwalia, Kumar Vaibhav, Ashis Mondal, Nikhil Sahajpal, Shaheen Islam, Sadanand Fulzele, Vamsi Kota, Krishnan Dhandapani, Babak Baban, Amyn M. Rojiani, Ravindra Kolhe
Article
Pharmacology & Pharmacy
Hesam Khodadadi, Evila Lopes Salles, Abbas Jarrahi, Fairouz Chibane, Vincenzo Costigliola, Jack C. Yu, Kumar Vaibhav, David C. Hess, Krishnan M. Dhandapani, Babak Baban
CANNABIS AND CANNABINOID RESEARCH
(2020)