☆ 4.6 Article

MicroRNAs in Cerebral Ischemia

TRANSLATIONAL STROKE RESEARCH (2010)

期刊

TRANSLATIONAL STROKE RESEARCH

卷 1, 期 4, 页码 287-303

出版社

SPRINGER

DOI: 10.1007/s12975-010-0035-3

关键词

MicroRNA; Gene; Cerebral ischemia; MCAo; Biomarkers; Acute phase

类别

Clinical Neurology Neurosciences

资金

National Research Foundation
National University of Singapore, Singapore

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Protocol

Reagent

摘要

Pathogenesis of cerebral ischemia has so far been described in the context of proteins and the pathways that they regulate. The discovery of biomarkers has also been focussed mainly on proteins and to some extent on the mRNAs that encode them. The knowledge on the role of microRNAs in understanding the pathogenesis of cerebral ischemia is still at its infancy. In this study, using rat models subjected to middle cerebral artery occlusion, we have profiled the microRNAs at different reperfusion times (0 to 48 h) to understand the progression of cerebral ischemia. We have also attempted to correlate the expression of microRNAs to treatment with an NMDA antagonist (MK801) and to protein expression with the hope of demonstrating the potential use of microRNAs as early biomarkers of stroke.

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