Article
Chemistry, Medicinal
Ling Zou, Par Matsson, Adrian Stecula, Huy X. Ngo, Arik A. Zur, Kathleen M. Giacomini
Summary: This study characterized the interactions of drug metabolites with renal drug transporters OAT1 and OAT3, finding varying inhibitory effects. Some metabolites showed more potent inhibition, which could potentially impact drug therapy and adverse reactions in clinical settings.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Medicinal
Dalong Wang, Jing Liu, Xiaodong Chen, Jing Chen, Tingting Zhao, Jie Du, Changyuan Wang, Qiang Meng, Huijun Sun, Fangjun Wang, Kexin Liu, Jingjing Wu
Summary: This study investigates the potential nephrotoxicity of icaritin and its underlying mechanism. The results suggest that icaritin induces cell death and apoptosis in HK-2 cells, and causes tubular damage in mice. Proteomic analysis reveals that icaritin affects lipid metabolism and iron death pathways. These findings shed light on the nephrotoxicity induced by icaritin.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Qisheng Lin, Shu Li, Haijiao Jin, Hong Cai, Xuying Zhu, Yuanting Yang, Jingkui Wu, Chaojun Qi, Xinghua Shao, Jialin Li, Kaiqi Zhang, Wenyan Zhou, Minfang Zhang, Jiayi Cheng, Leyi Gu, Shan Mou, Zhaohui Ni
Summary: This study investigated the mechanism by which mitophagy protects against ferroptosis in cisplatin-induced acute kidney injury. The results showed aggravated iron accumulation, lipid peroxidation, and ferroptosis in mice lacking BNIP3, Pink1, or Park2. Additionally, the synthetic antioxidant ferroptosis inhibitor, Ferrstatin-1, rescued the effects of mitophagy inhibition.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Cell Biology
Shanshan Wei, Wanjun Ma, Bikui Zhang, Wenqun Li
Summary: NLRP3 inflammasome plays a crucial role in drug-induced toxicity, participating in the initiation and exacerbation of toxicity through multiple signaling pathways. Progress has been made in therapeutic strategies targeting NLRP3 inflammasome inhibition for drug-induced toxicity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Infectious Diseases
Jihyun Yang, Yoon Sook Ko, Hee Young Lee, Yina Fang, Se Won Oh, Myung-Gyu Kim, Won Yong Cho, Sang-Kyung Jo
Summary: Piperacillin/tazobactam (PT) is commonly used in intensive care for critically ill patients, but the mechanisms of its nephrotoxicity are unclear. This study demonstrated that PT directly induces oxidative stress and mitochondrial damage in renal tubular cells, suggesting a direct nephrotoxic effect.
Review
Pharmacology & Pharmacy
Tommaso Mazzierli, Federica Allegretta, Enrico Maffini, Marco Allinovi
Summary: Drug-induced thrombotic microangiopathy (DITMA) accounts for 10%-13% of all thrombotic microangiopathy (TMA) cases and about 20%-30% of secondary TMAs, just behind pregnancy-related and infection-related forms. The scientific literature on DITMA is limited, leading to poor understanding of its mechanisms and management. In this review, we provide an updated list of TMA-associated drugs and describe the clinical features of DITMA, as well as analyze the association between signs/symptoms and specific causative drugs. We also discuss the role of complement system and genetic deregulation in DITMA and propose a treatment approach based on recent literature data.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Barakat M. Alrashdi, Roaya A. Mohamed, Amal H. Mohamed, Feryal A. Samoul, Mazen I. Mohamed, Mohsen M. Moussa, Saad M. Alrashidi, Bassel Dawod, Ola A. Habotta, Ahmed E. Abdel Moneim, Shimaa S. Ramadan
Summary: This study found that turmeric conjugated with selenium nanoparticles effectively counteracted cisplatin-induced renal impairment in mice. Turmeric or turmeric-seNPs therapy significantly reduced renal dysfunction and inflammation, improved oxidative status, and inhibited renal apoptosis in cisplatin-treated mice.
BIOSCIENCE REPORTS
(2023)
Article
Multidisciplinary Sciences
Asmae Elghouizi, Noori Al-Waili, Nawal Elmenyiy, Salma Elfetri, Abderrazak Aboulghazi, Ahmed Al-Waili, Badiaa Lyoussi
Summary: Bee pollen extract (BPE) has antioxidant activity and exhibits a protective effect against ethylene glycol-induced kidney injury and crystalluria, possibly by increasing urine volume, excretion of sodium and magnesium, and reducing proteinuria.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
Paula Martinez de la Cruz, Amir Shabaka, Xabier Mielgo-Rubio, Carmen Guerrero-Marquez, Sara Gimenez-Moyano, Gema Fernandez-Juarez
Summary: This case report highlights acute kidney injury in a patient receiving tipifarnib therapy for squamous cell carcinoma of the lung. High-dose corticosteroids were successful in achieving full recovery of kidney function within a five-week period.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Mercy Jelagat Karoney, Mathew Kirtptonui Koech, Evangeline Wawira Njiru, Willis Dixon Owino Ong'or
Summary: TDF is a widely used anti-retroviral therapy drug, but it can cause proximal tubular renal dysfunction. This study found a higher prevalence of proximal tubular renal dysfunction in patients on TDF treatment, but no significant difference in overall renal function.
Review
Medicine, General & Internal
Robert J. Unwin
Summary: Toxic nephropathy, a growing concern, is often caused by new drugs and polypharmacy. Patients' lack of knowledge about their medications and the prevalence of unapproved drugs contribute to the problem. Early detection, drug withdrawal, and supportive care are crucial for effective treatment.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Qijing Wu, Juan Chen, Xiyin Zheng, Jing Song, Lulu Yin, Hai Guo, Qian Chen, Yi Liu, Qianli Ma, Hong Zhang, Qianqian Yang
Summary: The study aimed to evaluate the protective effect of kaempferol (KPF) in doxorubicin (DOX)-induced nephrotoxicity. The results showed that KPF could alleviate DOX-induced renal injury, improve proteinuria and renal function, restore antioxidant activity in kidneys, suppress oxidative stress, and inhibit the activation of the MAPK signaling pathway. In cell experiments, KPF also inhibited DOX-induced ROS overproduction, reduced cell damage and loss of viability. Therefore, KPF may provide a viable solution to lessen renal toxicity in cancer patients receiving DOX.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Kai Yao, Zhi-Hui Zhang, Ming-Dong Liu, Feng-Wen Niu, Xi Li, De-Mao Ding, Da-Ming Wang, De-Xin Yu, De-Xiang Xu, Dong-Dong Xie
Summary: This study aimed to explore the role of lipopolysaccharide (LPS) on calcium oxalate nephrolithiasis formation and the antagonistic effect of melatonin. The results showed that LPS promoted the adhesion and deposition of calcium oxalate crystals, while melatonin inhibited the inflammatory response and stone formation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Toxicology
Dan Sang, Xinyue Duan, Xiaoli Yu, Jiabin Zang, Lan Liu, Guifu Wu
Summary: This study investigates the mechanism of PGAM5 in promoting lipid-induced necroptosis in renal tubular epithelial cells (RTECs). The study finds that upregulation of PGAM5 activates the necroptosis pathway, leading to cell death. However, silencing PGAM5 can prevent these changes, protecting RTECs from lipid-induced necroptosis.
TOXICOLOGY LETTERS
(2023)
Article
Pharmacology & Pharmacy
Xiaolan Mo, Xiujuan Chen, Chifong Leong, Xia Gao, Yingjie Li, Xin Liao, Huabin Yang, Huiyi Li, Fan He, Yanling He, Yilu Chen, Huiying Liang, Min Huang, Jiali Li
Summary: This study aimed to develop and validate a predictive model of TAC-induced tubular toxicity in children with NS using machine learning based on comprehensive clinical and genetic variables. The model showed good performance in predicting nephrotoxicity in NS patients, providing a useful tool for physicians to optimize treatment regimen.
FRONTIERS IN PHARMACOLOGY
(2021)