Article
Rheumatology
Wanlong Wu, Wenwen Xu, Wenjia Sun, Danting Zhang, Jiangfeng Zhao, Qun Luo, Xiaodong Wang, Feng Zhu, Yu Zheng, Yu Xue, Weiguo Wan, Huaxiang Wu, Qian Han, Shuang Ye
Summary: This study aimed to establish and validate a clinical prediction model for 6-month all-cause mortality in Chinese patients with anti-MDA5 positive DM-ILD. The results showed that a categorical predictor based on forced vital capacity (FVC)% was identified and validated as an independent prognostic factor, which could effectively distinguish the risk stages in patients and facilitate risk stratification in clinical practice.
Article
Rheumatology
Takashi Nawata, Yuichiro Shirai, Mikito Suzuki, Masataka Kuwana
Summary: The study found that in patients with SSc-ILD, the decline in FVC is not only related to the progression of ILD, but also to the atrophy of accessory respiratory muscles. The decrease in chest wall muscle area may affect the lung function of patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Masakuni Ueyama, Seishu Hashimoto, Atsushi Takeda, Naoto Maruguchi, Ryo Yamamoto, Kazuki Matsumura, Satoshi Nakamura, Satoru Terada, Takashi Inao, Yusuke Kaji, Takehiro Yasuda, Takashi Hajiro, Eisaku Tanaka, Yoshio Taguchi, Satoshi Noma
Summary: This study evaluated the ability of dynamic chest radiography (DCR) to predict forced vital capacity (FVC) and other PFT parameters of interstitial lung disease (ILD) patients. Lung volumes measured by DCR were found to correlate with lung function, leading to the development of prediction models with high predictive power for FVC and other PFT parameters.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Review
Respiratory System
Steven D. Nathan, Jack Wanger, Joseph D. Zibrak, Mark L. Wencel, Cindy Burg, John L. Stauffer
Summary: FVC decline in the clinic plays a critical role in monitoring disease progression in patients with IPF, but additional measures should be considered to facilitate decision-making about disease management. Home spirometry devices may offer potential for more frequent and accurate data collection.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2021)
Article
Respiratory System
Michael Kreuter, Elisabeth Bendstrup, Stephane Jouneau, Toby M. Maher, Yoshikazu Inoue, Corinna Miede, Dirk Lievens, Bruno Crestani
Summary: This study analyzed the relationship between baseline BMI and weight change and outcomes in patients with pulmonary fibrosis. The results showed that lower BMI and weight loss were associated with worse prognosis, indicating the need for measures to prevent weight loss.
RESPIRATORY RESEARCH
(2023)
Article
Respiratory System
Toby M. Maher, Susanne Stowasser, Florian Voss, Elisabeth Bendstrup, Michael Kreuter, Fernando J. Martinez, Patricia J. Sime, Christian Stock
Summary: This study used clinical trial data of nintedanib in patients with pulmonary fibrosis to assess decline in forced vital capacity (FVC) as a surrogate for mortality. The results showed a strong association between the rate of decline in FVC % predicted and the risk of death over 52 weeks, supporting FVC decline as a surrogate for mortality in these patients.
Article
Respiratory System
Megan L. Neely, Anne S. Hellkamp, Shaun Bender, Jamie L. Todd, Timothy Liesching, Tracy R. Luckhardt, Justin M. Oldham, Rishi Raj, Eric S. White, Scott M. Palmer
Summary: This study evaluated the trajectories of lung function decline in patients with IPF and found that IPF is characterized by a progressive decline in lung function. Male, white, patients with a family history of ILD, oxygen users, and those using antifibrotic therapy had a greater decline in lung function.
RESPIRATORY RESEARCH
(2023)
Article
Medicine, General & Internal
Pengfei Wang, Li Zhang, Qian Guo, Lifen Zhao, Yanyan Hao
Summary: The decision for definitive therapy for connective tissue disease-associated interstitial lung disease (CTD-ILD) is challenging. Both mycophenolate mofetil and cyclophosphamide improve pulmonary function, but mycophenolate mofetil has fewer toxic effects and increased patient survival compared to cyclophosphamide.
Article
Clinical Neurology
Yuko Kobayakawa, Koji Todaka, Yu Hashimoto, Senri Ko, Wataru Shiraishi, Junji Kishimoto, Jun-ichi Kira, Ryo Yamasaki, Noriko Isobe
Summary: The study developed a new indicator, FVC-DiP, to assess disease progression rate in ALS. This indicator reflected disease progression patterns through %FVC decline, and showed associations with prognosis and TRICALS risk profile.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Respiratory System
John S. Kim, Michaela R. Anderson, Elana J. Bernstein, Elizabeth C. Oelsner, Ganesh Raghu, Imre Noth, Michael Y. Tsai, Mary Salvatore, John H. M. Austin, Eric A. Hoffman, R. Graham Barr, Anna J. Podolanczuk
Summary: The study found that higher baseline D-dimer concentrations were associated with markers of early lung injury and scarring, especially among those older than 65 years.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Environmental Sciences
Han Wu, Yingxiu Zhang, Jing Wei, Pascal Bovet, Min Zhao, Wenhui Liu, Bo Xi
Summary: This study examines the association between short-term exposure to ambient PM1, PM1-2.5, and PM2.5 and forced vital capacity (FVC). The results show that exposure to PM1 and PM2.5 is associated with decreased FVC.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Respiratory System
Yoshikazu Inoue, Athol U. Wells, Jin Woo Song, Zuojun Xu, Hideya Kitamura, Takafumi Suda, Masaki Okamoto, Heiko Mueller, Carl Coeck, Klaus B. Rohr, Martin Kolb, Kevin K. Brown
Summary: In the INBUILD trial, nintedanib was found to slow down the decline in forced vital capacity in Asian patients with progressive fibrosing ILDs, although some patients experienced gastrointestinal adverse events.
Article
Medicine, General & Internal
Nanako Shiokawa, Tatsuma Okazaki, Yoshimi Suzukamo, Midori Miyatake, Mana Kogure, Naoki Nakaya, Atsushi Hozawa, Satoru Ebihara, Shin-Ichi Izumi
Summary: Impaired %FVC is associated with higher all-cause mortality in aged adults, and strong leg force may improve this relationship. Among the three major leading causes of death, impaired %FVC is specifically related to higher pneumonia mortality. Weak leg force might indicate sarcopenia, and its prevention may reduce the risk of higher pneumonia mortality associated with impaired %FVC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Woo Kyung Ryu, Hyungkeun Cha, Mi Hwa Park, Jung Soo Kim, Jeong-Seok Choi, Lucia Kim, Kyung-Hee Lee, Hae-Seong Nam
Summary: This study reports a successful crizotinib retreatment after crizotinib-ILD in a patient with ROS1-rearranged NSCLC and proposes a retreatment strategy based on a literature review.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Keigo Koda, Yasunori Enomoto, Yoichiro Aoshima, Yusuke Amano, Shinpei Kato, Hirotsugu Hasegawa, Takashi Matsui, Koshi Yokomura, Eisuke Mochizuki, Shun Matsuura, Naoki Koshimizu, Meiko Morita, Suguru Kojima, Ayano Watanabe, Yoshiyuki Oyama, Masaki Ikeda, Hideki Kusagaya, Tomohiro Uto, Jun Sato, Shiro Imokawa, Masato Kono, Dai Hashimoto, Yosuke Kamiya, Mikio Toyoshima, Kazuhiro Asada, Masako Morita, Masashi Mikamo, Hideki Yasui, Hironao Hozumi, Masato Karayama, Yuzo Suzuki, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Takafumi Suda
Summary: Acute exacerbation of interstitial lung disease (ILD) during chemotherapy is a common complication among lung cancer patients, particularly those with lower forced vital capacity (FVC) percentage. However, even in this population, a passable treatment response can still be expected.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2022)
Article
Chemistry, Multidisciplinary
Andrea Smargiassi, Riccardo Inchingolo, Lucio Calandriello, Francesco Lombardi, Angelo Calabrese, Matteo Siciliano, Anna Rita Larici, Libertario Demi, Luca Richeldi, Gino Soldati
APPLIED SCIENCES-BASEL
(2020)
Article
Medicine, General & Internal
Elisabetta Cocconcelli, Roberto Tonelli, Gianluca Abbati, Alessandro Marchioni, Ivana Castaniere, Filippo Pelizzaro, Francesco Paolo Russo, Alberto Vegetti, Elisabetta Balestro, Antonello Pietrangelo, Luca Richeldi, Fabrizio Luppi, Paolo Spagnolo, Enrico Clini, Stefania Cerri
Summary: Data is lacking on subclinical fibrosis in multiple organs in patients with idiopathic lung fibrosis (IPF). This study found that more than one-third of IPF patients had concomitant subclinical liver fibrosis, which negatively affected overall survival. Higher levels of AST to platelet ratio index (APRI) were identified as an independent predictor of survival. Further investigation is needed to clarify the mechanisms of multiorgan fibrosis and its clinical implications in IPF patients.
INTERNAL AND EMERGENCY MEDICINE
(2021)
Review
Respiratory System
Francesco Varone, Bruno Iovene, Giacomo Sgalla, Mariarosaria Calvello, Angelo Calabrese, Anna Rita Larici, Luca Richeldi
Article
Radiology, Nuclear Medicine & Medical Imaging
Geoffrey D. Rubin, Christopher J. Ryerson, Linda B. Haramati, Nicola Sverzellati, Jeffrey P. Kanne, Suhail Raoof, Neil W. Schluger, Annalisa Volpi, Jae-Joon Yim, Ian B. K. Martin, Deverick J. Anderson, Christina Kong, Talissa Altes, Andrew Bush, Sujal R. Desai, Onathan Goldin, Jin Mo Goo, Marc Humbert, Yoshikazu Inour, Hans-Ulrich Kauczor, Fengming Luo, Peter J. Mazzone, Mathias Prokop, Martine Remy-Jardin, Luca Richeldi, Cornelia M. Schaefer-Prokop, Noriyuki Tomiyama, Athol U. Wells, Ann N. Leung
Article
Cardiac & Cardiovascular Systems
Francesco Varone, Ludovica Friello, Chiara Di Blasi, Giacomo Sgalla, Marco Luigetti, Bruno Iovene, Luca Richeldi, Giacomo Della Marca, Valerio Brunetti
RESPIRATORY MEDICINE
(2020)
Article
Respiratory System
Giacomo Sgalla, Erminia Lo Greco, Mariarosaria Calvello, Francesco Varone, Bruno Iovene, Stefania Cerri, Pierluigi Donatelli, Ada Vancheri, Mauro Pavone, Fabrizio Luppi, Carlo Vancheri, Luca Richeldi
Article
Respiratory System
Mark G. Jones, Christopher R. T. Hillyar, Anjan Nibber, Alison Chisholm, Andrew Wilson, Toby M. Maher, Alan Kaplan, David Price, Simon Walsh, Luca Richeldi
Article
Respiratory System
Giacomo Malipiero, Giovanni Paoletti, Francesco Blasi, Pierluigi Paggiaro, Gianenrico Senna, Manuela Latorre, Marco Caminati, Giovanna Elisiana Carpagnano, Nunzio Crimi, Antonio Spanevello, Stefano Aliberti, Giorgio Walter Canonica, Enrico Heffler, M. Bonavia, C. Bucca, M. F. Caiaffa, C. Calabrese, G. Camiciottoli, C. Caruso, S. Centanni, M. E. Conte, A. G. Corsico, L. Cosmi, M. T. Costantino, S. D'Alo, M. D'Amato, S. Del Giacco, A. Farsi, E. Favero, B. M. P. Foschino, G. Guarnieri, G. Guida, S. Lo Cicero, C. Lombardi, L. Macchia, F. Mazza, F. Menzella, M. Milanese, P. Montuschi, M. Montagni, E. Nucera, R. Parente, G. Passalacqua, V Patella, G. Pelaia, L. Pini, L. Ricciardi, F. L. M. Ricciardolo, L. Richeldi, E. Ridolo, G. Rolla, P. Santus, N. Scichilone, P. Solidoro, G. Spadaro, A. Vianello, V. Viviano, M. R. Yacoub, M. C. Zappa
Summary: Bronchiectasis is a common comorbidity in severe asthma patients, with associations with worse asthma control, quality of life, lung function, and higher rate of exacerbations. Proper assessment and management of bronchiectasis are crucial in severe asthmatic patients.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Giacomo Sgalla, Marialessia Lerede, Luca Richeldi
Summary: Over the past two decades, there has been an increase in well-designed late-phase trials for Idiopathic Pulmonary Fibrosis (IPF) patients, resulting in the approval of the first effective therapies like pirfenidone and nintedanib. Currently, novel potential treatments for IPF are undergoing phase III trials, which could potentially bring a new breakthrough in IPF management.
EXPERT OPINION ON ORPHAN DRUGS
(2021)
Article
Critical Care Medicine
Ganesh Raghu, Martine Remy-Jardin, Luca Richeldi, Carey C. Thomson, Yoshikazu Inoue, Takeshi Johkoh, Michael Kreuter, David A. Lynch, Toby M. Maher, Fernando J. Martinez, Maria Molina-Molina, Jeffrey L. Myers, Andrew G. Nicholson, Christopher J. Ryerson, Mary E. Strek, Lauren K. Troy, Marlies Wijsenbeek, Manoj J. Mammen, Tanzib Hossain, Brittany D. Bissell, Derrick D. Herman, Stephanie M. Hon, Fayez Kheir, Yet H. Khor, Madalina Macrea, Katerina M. Antoniou, Demosthenes Bouros, Ivette Buendia-Roldan, Fabian Caro, Bruno Crestani, Lawrence Ho, Julie Morisset, Amy L. Olson, Anna Podolanczuk, Venerino Poletti, Moises Selman, Thomas Ewing, Stephen Jones, Shandra L. Knight, Marya Ghazipura, Kevin C. Wilson
Summary: This article provides updates on the guidelines for idiopathic pulmonary fibrosis (IPF) and addresses the progression of pulmonary fibrosis in patients with interstitial lung diseases (ILDs) other than IPF. The recommendations are based on consensus and systematic reviews, aiming to provide evidence-based guidance for clinicians.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Respiratory System
John S. Kim, Sydney B. Montesi, Ayodeji Adegunsoye, Stephen M. Humphries, Margaret L. Salisbury, Lida P. Hariri, Jonathan A. Kropski, Luca Richeldi, Athol U. Wells, Simon Walsh, R. Gisli Jenkins, Ivan Rosas, Imre Noth, Gary M. Hunninghake, Fernando J. Martinez, Anna J. Podolanczuk
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Respiratory System
Francesco Varone, Giacomo Sgalla, Bruno Iovene, Luca Richeldi
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2020)
Review
Respiratory System
Arata Azuma, Luca Richeldi
TUBERCULOSIS AND RESPIRATORY DISEASES
(2020)
Article
Critical Care Medicine
Peter M. George, Paolo Spagnolo, Michael Kreuter, Goksel Altinisik, Martina Bonifazi, Fernando J. Martinez, Philip L. Molyneaux, Elisabetta A. Renzoni, Luca Richeldi, Sara Tomassetti, Claudia Valenzuela, Carlo Vancheri, Francesco Varone, Vincent Cottin, Ulrich Costabel
LANCET RESPIRATORY MEDICINE
(2020)
Meeting Abstract
Critical Care Medicine
A. Hajari Case, D. A. Lynch, J. H. Chung, J. Huang, Y. Choi, L. Lofaro, D. Pankratz, G. Kennedy, S. Bhorade, L. Richeldi, F. J. Martinez, G. Raghu
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)