Article
Immunology
Andrew D. Gaudet, Laura K. Fonken, Monica T. Ayala, Steven F. Maier, Linda R. Watkins
Summary: Aging increases susceptibility to pain and death after SCI in mice, while deletion of miR-155 reduces pain symptoms and mortality. Aging mice exhibit heightened heat sensitivity and evoked pain symptoms, highlighting the importance of studying geriatric models of SCI.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Biochemistry & Molecular Biology
Hanns Ulrich Zeilhofer, Karolina Werynska, Jacinthe Gingras, Gonzalo E. Yevenes
Summary: Restoring proper synaptic inhibition in the spinal cord, particularly through targeting the alpha 3 subtype of glycine receptors, may help reduce deleterious side effects and increase tolerability in chronic pain states. This review provides an update on the physiological properties and functions of alpha 3 subtype GlyRs and related drug discovery programs.
Article
Biochemistry & Molecular Biology
Eva Uchytilova, Diana Spicarova, Jiri Palecek
Summary: The study reveals that the thermal and mechanical hypersensitivity induced by co-administration of BK and OLDA via i.t. administration is mediated by the activation of spinal TRPV1 channels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Ruizhen Huang, Shuang Han, Yuxin Qiu, Taihe Zhou, Yuning Wu, Hongchu Du, Jing Xu, Xuhong Wei
Summary: This study found that high-frequency stimulation of the sciatic nerve leads to an increase in L-lactate and MCT1/2 in the spinal dorsal horn, and the involvement of spinal astrocytes enhances synaptic transmission at the C-fiber synapse, contributing to pain chronicity.
Review
Clinical Neurology
Zhen-Rong Zhang, Yao Wu, Wen-Jing Wang, Fang-Yong Wang
Summary: The role of GABAergic cell transplantation in improving neuropathic pain is significant, showing statistically significant improvements in allodynia and hyperalgesia. Differentiated GABAergic cells and avoiding the use of antibiotics may have a better effect in improving neuropathic pain.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Alfonso Mata-Bermudez, Araceli Diaz-Ruiz, Masha Burelo, Betzabeth Anali Garcia-Martinez, Gustavo Jardon-Guadarrama, Francisco Calderon-Estrella, Andrea Rangel-Hernandez, Cuauhtemoc Perez-Gonzalez, Rios Camilo
Summary: The study evaluated the effect of dapsone on tactile allodynia and mechanical hyperalgesia in a spinal cord injury model in rats, and found that it can decrease nociceptive behaviors and oxidative stress. The anti-nociceptive effect of dapsone is regulated through the decrease of oxidative stress and the excitotoxicity associated with the activation of NMDA receptors.
Review
Pharmacology & Pharmacy
David Cabanero, Eva Villalba-Riquelme, Gregorio Fernandez-Ballester, Asia Fernandez-Carvajal, Antonio Ferrer-Montiel
Summary: Chronic pain is a significant burden for society, with higher prevalence and severity in females. Transient receptor potential channels (TRP), particularly TRPV1, TRPA1, and TRPM8, play important roles in the perception of hot and cold stimuli and have been extensively studied for their involvement in acute and chronic pain. This review highlights the differential modulation of these channels in males and females, potentially due to sexual hormones, and explores the pharmacology of thermoTRP channels in chronic migraine and chemotherapy-induced peripheral neuropathy. The development of personalized analgesic treatments for chronic pain through targeting these channels represents an important opportunity.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Neurosciences
Mennatallah Elshennawy, Omar Ouachikh, Youssef Aissouni, Shahira Youssef, Shahira S. Zaki, Franck Durif, Aziz Hafidi
Summary: This study assessed thermal nociceptive behavior in rats with 6-OHDA-induced PD, finding increased sensitivity to cold temperatures and mechanical hypersensitivity. Dopamine receptor agonist Ropinirole alleviated cold allodynia. Molecular markers of pain processes were elevated in specific brain regions in 6-OHDA-lesioned rats, indicating alterations in excitation and inhibition in the spinal dorsal horn. Overall, the study demonstrated cold thermal hypersensitivity, alongside mechanical hypersensitivity, in 6-OHDA-lesioned rats.
Article
Biotechnology & Applied Microbiology
Volodymyr Krotov, Volodymyr Medvediev, Ibrahim Abdallah, Arseniy Bozhenko, Mykhailo Tatarchuk, Yevheniia Ishchenko, Leonid Pichkur, Serhii Savosko, Vitaliy Tsymbaliuk, Olga Kopach, Nana Voitenko
Summary: Motor disability is a common outcome of spinal cord injury (SCI), and the recovery of motor function depends on the severity of the injury. Pain is often comorbid with SCI, but its prediction remains poor. Our study found that in young rats with SCI, motor deficit can either improve or worsen over 4-5 weeks after injury, and all young rats showed changes in nociceptive sensitivity. The results suggest that motor dysfunction and pain syndromes following SCI can be predictable and can aid in long-term rehabilitation and recovery.
BIOENGINEERING-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Diane Pelzer, Lauren S. Phipps, Raphael Thuret, Carlos J. Gallardo-Dodd, Syed Murtuza Baker, Karel Dorey
Summary: This study identified several genes specifically expressed in the spinal cord during regeneration, highlighting the importance of Foxm1 in spinal cord regeneration. Foxm1 was found to regulate the fate of neural progenitors post-division, rather than controlling their cell cycle length. The reduction in neurons in the regenerating spinal cord of foxm1(-/-) tadpoles suggests that neuronal differentiation plays a crucial role in the regenerative process.
Article
Pharmacology & Pharmacy
Neha Munawar, Joelle Nader, Najat H. Khadadah, Ashraf Al Madhoun, Waleed Al-Ali, Linu A. Varghese, Willias Masocha, Fahd Al-Mulla, Milad S. Bitar
Summary: This study found that alpha-2A adrenoceptors (alpha 2-AR) in the nervous system of streptozotocin diabetic rats are upregulated, and the upregulation is associated with increased pain sensitivity. Chronic administration of the selective alpha 2-AR agonist guanfacine can downregulate the upregulation of alpha 2-AR and relieve hyperalgesia and allodynia in diabetic animals. These findings suggest that guanfacine may have potential as a potent analgesic for diabetic neuropathic pain.
Article
Behavioral Sciences
Guadalupe Garcia, Vladimir A. Martinez-Rojas, Janet Murbartian
Summary: TREK-1 channels play a crucial role in acute and persistent nociceptive hypersensitivity, with selective blockade or activation affecting pain behaviors. The activity of TREK-1 at peripheral and spinal sites can reduce neuronal excitability in a formalin-induced nociception model.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Cell Biology
Robert Chevreau, Hussein Ghazale, Chantal Ripoll, Chaima Chalfouh, Quentin Delarue, Anne Laure Hemonnot-Girard, Daria Mamaeva, Helene Hirbec, Bernard Rothhut, Shalaka Wahane, Florence Evelyne Perrin, Harun Najib Noristani, Nicolas Guerout, Jean Philippe Hugnot
Summary: Ependymal cells in the adult spinal cord activate multiple signaling pathways after injury, downregulate cilia-associated genes, upregulate various genes including Osmr, and the Osmr receptor Oncostatin may regulate the fate of ependymal cells towards astrocytic differentiation by affecting cell proliferation and differentiation.
Article
Biochemistry & Molecular Biology
Mark Kozsurek, Kornel Kiraly, Klara Gyimesi, Erika Lukacsi, Csaba Fekete, Balazs Gereben, Petra Mohacsik, Zsuzsanna Helyes, Kata Bolcskei, Valeria Tekus, Karoly Pap, Edina Szucs, Sandor Benyhe, Timea Imre, Pal Szabo, Andrea Gajtko, Krisztina Hollo, Zita Puskar
Summary: CART peptides have various physiological and pathological roles, but their mechanisms remain unknown. We found that CART(55-102) can inhibit DPP4 in astrocytes, leading to reduced neuroinflammation and antihyperalgesic effects in rats. CART(55-102) is involved in regulating spinal pain transmission during peripheral inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Donya Ziafatdoost Abed, Reyhaneh Sadeghian, Saeed Mohammadi, Muhammad Akram
Summary: The essential oil of Thymus persicus showed strong antinociceptive and anti-neuropathic effects in Swiss mice, involving various signaling pathways and receptors.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Neurosciences
Eric M. Gold, Vitaly Vasilevko, Jonathan Hasselmann, Casey Tiefenthaler, Danny Hoa, Kasuni Ranawaka, David H. Cribbs, Brian J. Cummings
Article
Biochemical Research Methods
Andrea Anzalone, Jenu V. Chacko, Rebecca A. Nishi, Courtney Dumont, Dominique Smith, Lonnie D. Shea, Michelle A. Digman, Brian J. Cummings, Aileen J. Anderson
JOURNAL OF BIOMEDICAL OPTICS
(2018)
Article
Biochemical Research Methods
Katja M. Piltti, Brian J. Cummings, Krystal Carta, Ayla Manughian-Peter, Colleen L. Worne, Kulbir Singh, Danier Ong, Yuriy Maksymyuk, Michelle Khine, Aileen J. Anderson
Article
Biotechnology & Applied Microbiology
Jonghyuck Park, Joseph T. Decker, Daniel J. Margul, Dominique R. Smith, Brian J. Cummings, Aileen J. Anderson, Lonnie D. Shea
Article
Biotechnology & Applied Microbiology
Dominique R. Smith, Daniel J. Margul, Courtney M. Dumont, Mitchell A. Carlson, Mary K. Munsell, Mitchell Johnson, Brian J. Cummings, Aileen J. Anderson, Lonnie D. Shea
BIOTECHNOLOGY AND BIOENGINEERING
(2019)
Article
Cell & Tissue Engineering
Courtney M. Dumont, Mary K. Munsell, Mitchell A. Carlson, Brian J. Cummings, Aileen J. Anderson, Lonnie D. Shea
TISSUE ENGINEERING PART A
(2018)
Article
Engineering, Biomedical
Courtney M. Dumont, Mitchell A. Carlson, Mary K. Munsell, Andrew J. Ciciriello, Katerina Strnadova, Jonghyuck Park, Brian J. Cummings, Aileen J. Anderson, Lonnie D. Shea
ACTA BIOMATERIALIA
(2019)
Article
Materials Science, Biomaterials
Dominique R. Smith, Courtney M. Dumont, Andrew J. Cicirirllo, Amina Guo, Rayindra Tatineni, K. Munsell, Brian J. Cummings, Aileen J. Anderson, Lonnie D. Shea
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2019)
Article
Biology
Francisca Benavente, Katja Piltti, Mitra J. Hooshmand, Aileen A. Nava, Anita Lakatos, Brianna G. Feld, Dana Creasman, Paul D. Gershon, Aileen Anderson
Article
Cell & Tissue Engineering
Mirna Hassoun, Sidney Golub, Sheldon Greenfield, Joshua D. Grill, Brian J. Cummings
Summary: Attending stem-cell seminars and reviewing online presentations revealed that the advertised stem-cell therapies from direct-to-consumer clinics lacked proper clinical evidence and support from peer-reviewed literature.
REGENERATIVE MEDICINE
(2022)
Article
Engineering, Biomedical
Brian C. Ross, Robert N. Kent III, Michael N. Saunders, Samantha R. Schwartz, Brooke M. Smiley, Sarah E. Hocevar, Shao-Chi Chen, Chengchuan Xiao, Laura A. Williams, Aileen J. Anderson, Brian J. Cummings, Brendon M. Baker, Lonnie D. Shea
Summary: Design parameters of microporous annealed particles (MAPs) tubes with different sizes were investigated for the treatment of spinal cord injury (SCI). It was found that tubes composed of 60-micron beads can effectively reduce scarring, increase immune cell density, and promote functional recovery. These studies highlight the importance of bead size in MAP construction.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Cell Biology
Anna Badner, Brian J. Cummings
Summary: This article provides an overview of the response of central nervous system progenitor pools to traumatic brain injury and their potential effects on recovery and pathophysiology. It discusses the need for a better understanding of the diverse progenitor populations in the adult brain and their specific reactions to trauma in order to tailor treatments for optimal outcomes. The article also highlights the importance of characterizing precursor spatial localization, transcriptional profile, morphology, and functional synaptic integration for meaningful outcome assessment.
NEURAL REGENERATION RESEARCH
(2022)
Meeting Abstract
Cell & Tissue Engineering
K. M. Piltti, A. Lakatos, B. J. Cummings, A. J. Anderson
CELL TRANSPLANTATION
(2022)
Meeting Abstract
Biotechnology & Applied Microbiology
Jonghyuck Park, Joseph Decker, Daniel Margul, Brian Cummings, Aileen Anderson, Lonnie Shea
