Article
Endocrinology & Metabolism
Tomoya Mita, Naoto Katakami, Mitsuyoshi Takahara, Masaru Kawashima, Fumitaka Wada, Hiroki Akiyama, Naru Morita, Yoko Kidani, Toshitaka Yajima, Iichiro Shimomura, Hirotaka Watada
Summary: This study examined the change in treatment satisfaction and factors affecting this change among patients with early-stage type 2 diabetes mellitus in Japan.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Hao Wu, Zongshi Lu, Runyao Chen, Quanfang Cai, Miaomiao Wang, Liting Zhang, Zhiming Zhu
Summary: This study identified AGI use, concomitant gastrointestinal diseases, higher TSH levels, and female sex as independent risk factors for the gastrointestinal side effects of liraglutide treatment in patients with T2DM. Further research is needed to understand these interactions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yu Su, Shuo Zhang, Zezhen Wu, Weiting Liu, Jingxian Chen, Feiying Deng, Fengwu Chen, Dan Zhu, Kaijian Hou
Summary: This study evaluated the treatment effect and pharmacoeconomic value of Dulaglutide in women with type 2 diabetes. The results showed that Dulaglutide and Liraglutide both reduced blood glucose levels, improved biochemical index, and HOMA-IR levels in women with type 2 diabetes. However, Dulaglutide was found to be more cost-effective and safer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Article
Cardiac & Cardiovascular Systems
Damien Denimal, Victoria Bergas, Jean-Paul Pais-de-Barros, Isabelle Simoneau, Laurent Demizieux, Patricia Passilly-Degrace, Benjamin Bouillet, Petit Jean-Michel, Alexia Rouland, Amandine Bataille, Laurence Duvillard, Bruno Verges
Summary: The study investigates the effects of the GLP-1 receptor agonist liraglutide on the levels of dihydroceramides (DhCer) and ceramides (Cer) in type 2 diabetes (T2D) patients. Results show that liraglutide reduces plasma levels of DhCer and Cer species, which may contribute to the cardiovascular benefits observed. Additionally, the decrease in plasma DhCer levels is independently associated with the reduction in liver fat content and insulin resistance.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Medicine, General & Internal
W. Timothy Garvey, Juan P. Frias, Ania M. Jastreboff, Carel W. le Roux, Naveed Sattar, Diego Aizenberg, Huzhang Mao, Shuyu Zhang, Nadia N. Ahmad, Mathijs C. Bunck, Imane Benabbad, Xiaotian M. Zhang
Summary: This study assessed the efficacy and safety of tirzepatide, a glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, for weight management in individuals with obesity and type 2 diabetes. The results showed that once-weekly tirzepatide treatment significantly reduced bodyweight and achieved clinically meaningful weight loss, with a safety profile comparable to other weight management therapies.
Article
Multidisciplinary Sciences
Emilie H. Zobel, Rasmus S. Ripa, Bernt J. von Scholten, Viktor Rotbain Curovic, Andreas Kjaer, Tine W. Hansen, Peter Rossing, Joachim Storling
Summary: Liraglutide has been found to exert anti-inflammatory effects in the peripheral blood mononuclear cells of individuals with type 2 diabetes, with no significant presence of GLP-1 receptor expression. Further research is needed to clarify the indirect effects of liraglutide on PBMC gene expression and establish the anti-inflammatory potential of GLP-1 receptor agonists.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Mohamed Rafiullah, Hicham Benabdelkamel, Afshan Masood, Aishah A. Ekhzaimy, Mohthash Musambil, Salini Scaria Joy, Assim A. Alfadda
Summary: This study investigated changes in the urinary proteomic profile of diabetic patients before and after liraglutide treatment using 2D-DIGE MALDI TOF mass spectrometry. The study found that 32 proteins showed significant changes after liraglutide treatment, with upregulation of albumin, serotransferrin, metallothionein-2, keratins K1 and K10. These findings suggest the renoprotective effect of liraglutide and highlight the need for further research on its molecular mechanisms.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Yijiong Tan, Qin Zhen, Xiaoying Ding, Tingting Shen, Fang Liu, Yufan Wang, Qidi Zhang, Renkun Lin, Lili Chen, Yongde Peng, Nengguang Fan
Summary: This study found that the use of Liraglutide treatment is associated with a reduced risk of liver fibrosis in patients with type 2 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Juan Du, Liuqing Xi, Zhongxiao Zhang, Xiaoxu Ge, Wenyi Li, Wenfang Peng, Xiaohong Jiang, Wen Liu, Nan Zhao, Xingyun Wang, Xirong Guo, Shan Huang
Summary: This study investigated the effects of newly developed long-acting GLP-1RAs, such as dulaglutide and liraglutide, on metabolic remodeling in patients with recent-onset T2D. Through untargeted metabolomics analysis, significant changes in metabolites were identified in T2D patients compared to the control group. Treatment with dulaglutide and liraglutide led to the regulation of different metabolites, particularly in glycerophospholipid metabolism, and enriched the insulin resistance pathway and type 2 diabetes mellitus.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Marja-Riitta Taskinen, Elias Bjornson, Niina Matikainen, Sanni Soderlund, Kirsi H. Pietilainen, Mari Ainola, Antti Hakkarainen, Nina Lundbom, Johannes Fuchs, Annika Thorsell, Linda Andersson, Martin Adiels, Chris J. Packard, Jan Boren
Summary: In subjects with type 2 diabetes, liraglutide demonstrated positive effects on postprandial apoB48 metabolism, including reducing apoB48 synthesis, improving chylomicron size, and decreasing direct clearance of chylomicrons, as well as lowering VLDL1-triglyceride secretion. The impact of liraglutide on insulin sensitivity altered certain associations related to chylomicron-apoB48 production and particle size, ultimately contributing to decreased generation of remnant lipoproteins.
DIABETES OBESITY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Katrina B. Dietsche, Sheela N. Magge, Sydney A. Dixon, Faith S. Davis, Andrea Krenek, Aruba Chowdhury, Lilian Mabundo, Michael Stagliano, Amber B. Courville, Shanna Yang, Sara Turner, Hongyi Cai, Kannan Kasturi, Arthur S. Sherman, Joon Ha, Eileen Shouppe, Mary Walter, Peter J. Walter, Kong Y. Chen, Robert J. Brychta, Cody Peer, Yi Zeng, William Figg, Fran Cogen, D. Elizabeth Estrada, Shaji Chacko, Stephanie T. Chung
Summary: This study evaluated the glucose-lowering mechanisms of metformin and liraglutide in African American youth with youth-onset type 2 diabetes. The results showed that both metformin and liraglutide improved glycemic control but did not suppress high rates of gluconeogenesis. Novel therapies targeting beta-cell function and elevated rates of gluconeogenesis are needed for youth-onset type 2 diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Suvanjaa Sivalingam, Emil List Larsen, Daniel H. van Raalte, Marcel H. A. Muskiet, Mark M. Smits, Lennart Tonneijck, Jaap A. Joles, Bernt Johan von Scholten, Emilie Hein Zobel, Frederik Persson, Trine Henriksen, Lars Jorge Diaz, Tine W. Hansen, Henrik Enghusen Poulsen, Peter Rossing
Summary: This post-hoc analysis of two clinical trials showed that 12 weeks of treatment with liraglutide or sitagliptin did not have a beneficial effect on oxidatively generated modifications of nucleic acid in individuals with type 2 diabetes.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, Research & Experimental
Simeon I. Taylor, Zhinous Shahidzadeh Yazdi, Amber L. Beitelshees
Summary: Diabetes mellitus is a significant public health issue, with pharmacotherapy aiming to prevent complications. Clinical trials have shown that intensive glycemic control can slow the progression of complications, with some drugs also demonstrating cardiovascular benefits and slowed progression of diabetic kidney disease.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Pharmacology & Pharmacy
Morteza Rabiei, Soheila Kashanian, Gholamreza Bahrami, Hossein Derakhshankhah, Ebrahim Barzegari, Seyedeh Sabereh Samavati, Steven J. P. McInnes
Summary: Integrating nanoparticles with dissolving microneedles creates a promising non-invasive drug delivery device that provides sustained release and eliminates the need for subcutaneous injection, while also enhancing mechanical strength. The flexible backing layer obtained through blending of PVP and PVA, maintains the native secondary structure of the encapsulated drug according to CD analysis.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Lee M. Kaplan, Angela Golden, Kimberly Jinnett, Ronette L. Kolotkin, Theodore K. Kyle, Michelle Look, Joseph Nadglowski, Patrick M. O'Neil, Thomas Parry, Kenneth J. Tomaszewski, Boris Stevenin, Soren Kruse Lilleore, Nikhil V. Dhurandhar
Article
Surgery
Marius Svanevik, Hilde Risstad, Tor-Ivar Karlsen, Jon A. Kristinsson, Milada Cvancarova Smastuen, Ronette L. Kolotkin, Torgeir T. Sovik, Rune Sandbu, Tom Mala, Joran Hjelmesaeth
Article
Surgery
Ronette L. Kolotkin, Jaewhan Kim, Lance E. Davidson, Ross D. Crosby, Steven C. Hunt, Ted D. Adams
SURGERY FOR OBESITY AND RELATED DISEASES
(2018)
Article
Surgery
Tone Nygaard Flolo, Grethe S. Tell, Ronette L. Kolotkin, Anny Aasprang, Tone M. Norekval, Villy Vage, John R. Andersen
SURGERY FOR OBESITY AND RELATED DISEASES
(2019)
Article
Surgery
Kristine J. Steffen, Wendy C. King, Gretchen E. White, Leslee L. Subak, James E. Mitchell, Anita P. Courcoulas, David R. Flum, Gladys Strain, David B. Sarwer, Ronette L. Kolotkin, Walter Pories, Alison J. Huang
Article
Endocrinology & Metabolism
Ronette L. Kolotkin, Valerie S. L. Williams, Lisa von Huth Smith, Henrik Hjorth Meincke, Shanshan Qin, Nicole Williams, Sheri E. Fehnel
Summary: The IWQOL-Lite-CT, developed for assessing weight-related physical and psychosocial functioning, was confirmed for structure, reliability, and validity through two clinical trials. It demonstrated strong ability to detect change, discriminate between groups, and had responder thresholds ranging from 13.5 to 16.6 across composite scores.
Article
Endocrinology & Metabolism
Ronette L. Kolotkin, Ole Kleist Jeppesen, James Baker-Knight, Sang Yeoup Lee, Asako Tokita, Takashi Kadowaki
Summary: The study examined the impact of semaglutide 2.4 and 1.7 mg versus placebo on weight-related quality of life (WRQOL) and health-related quality of life (HRQOL) in individuals from East Asia. The results showed that semaglutide 2.4 mg significantly improved WRQOL and HRQOL scores, particularly in the psycho-social and physical domains. However, semaglutide 1.7 mg did not show significant effects on HRQOL.
Article
Endocrinology & Metabolism
Ronette L. Kolotkin, Valerie S. L. Williams, Claire M. Ervin, Nicole Williams, Henrik H. Meincke, Shanshan Qin, Lisa von Huth Smith, Sheri E. Fehnel
Article
Endocrinology & Metabolism
John Fastenau, Ronette L. Kolotkin, Ken Fujioka, Maria Alba, William Canovatchel, Shana Traina
Article
Public, Environmental & Occupational Health
Geir Kare Resaland, Eivind Aadland, Vegard Fusche Moe, Ronette L. Kolotkin, Sigmund A. Anderssen, John Roger Andersen
PREVENTIVE MEDICINE REPORTS
(2019)
Review
Endocrinology & Metabolism
P. A. Hegland, A. Aasprang, S. Hjelle Oygard, S. Nordberg, R. Kolotkin, C. Moltu, G. S. Tell, J. R. Andersen
Article
Endocrinology & Metabolism
R. L. Kolotkin, B. Gabriel Smolarz, H. H. Meincke, K. Fujioka
Article
Endocrinology & Metabolism
R. L. Kolotkin, R. D. Crosby, Z. Wang
Review
Endocrinology & Metabolism
R. L. Kolotkin, J. R. Andersen
Article
Endocrinology & Metabolism
R. L. Kolotkin, C. M. Ervin, H. H. Meincke, L. Hojbjerre, S. E. Fehnel