Impact of the Enhanced Permeability and Retention (EPR) Effect and Cathepsins Levels on the Activity of Polymer-Drug Conjugates
出版年份 2014 全文链接
标题
Impact of the Enhanced Permeability and Retention (EPR) Effect and Cathepsins Levels on the Activity of Polymer-Drug Conjugates
作者
关键词
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出版物
Polymers
Volume 6, Issue 8, Pages 2186-2220
出版商
MDPI AG
发表日期
2014-08-20
DOI
10.3390/polym6082186
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Randomized phase 2 study of pegylated SN-38 (EZN-2208) or irinotecan plus cetuximab in patients with advanced colorectal cancer
- (2013) Christopher R. Garrett et al. CANCER
- Validation of tumour models for use in anticancer nanomedicine evaluation: the EPR effect and cathepsin B-mediated drug release rate
- (2013) Ruth Duncan et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Phase I dose-escalation study of EZN-2208 (PEG-SN38), a novel conjugate of poly(ethylene) glycol and SN38, administered weekly in patients with advanced cancer
- (2013) Amita Patnaik et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology
- (2013) U. Prabhakar et al. CANCER RESEARCH
- First-in-human phase 1/2a trial of CRLX101, a cyclodextrin-containing polymer-camptothecin nanopharmaceutical in patients with advanced solid tumor malignancies
- (2013) Glen J. Weiss et al. INVESTIGATIONAL NEW DRUGS
- Randomized Multicenter Phase II Trial Comparing Two Schedules of Etirinotecan Pegol (NKTR-102) in Women With Recurrent Platinum-Resistant/Refractory Epithelial Ovarian Cancer
- (2013) Ignace B. Vergote et al. JOURNAL OF CLINICAL ONCOLOGY
- Tumor perfusion imaging predicts the intra-tumoral accumulation of liposomes
- (2013) Shawn Stapleton et al. JOURNAL OF CONTROLLED RELEASE
- Biodistribution and bioimaging studies of hybrid paclitaxel nanocrystals: Lessons learned of the EPR effect and image-guided drug delivery
- (2013) Christin P. Hollis et al. JOURNAL OF CONTROLLED RELEASE
- Two schedules of etirinotecan pegol (NKTR-102) in patients with previously treated metastatic breast cancer: a randomised phase 2 study
- (2013) Ahmad Awada et al. LANCET ONCOLOGY
- Profilin 1 as a Target for Cathepsin X Activity in Tumor Cells
- (2013) Urša Pečar Fonović et al. PLoS One
- Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis
- (2013) H. Cabral et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Correlating preclinical animal studies and human clinical trials of a multifunctional, polymeric nanoparticle
- (2013) S. Eliasof et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Markedly Enhanced Permeability and Retention Effects Induced by Photo-immunotherapy of Tumors
- (2012) Kohei Sano et al. ACS Nano
- The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo
- (2012) Hiroshi Maeda et al. ADVANCED DRUG DELIVERY REVIEWS
- Combined detection of serum matrix metalloproteinase 9, acetyl heparinase and Cathepsin L in diagnosis of ovarian cancer
- (2012) Wei Zhang et al. Chinese Journal of Cancer Research
- The regulation of cysteine cathepsins and cystatins in human gliomas
- (2012) Boris Gole et al. INTERNATIONAL JOURNAL OF CANCER
- Cathepsin B-cleavable doxorubicin prodrugs for targeted cancer therapy
- (2012) YAN-JUN ZHONG et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Abstract B52: Phase 1 study of XMT-1001, a novel water soluble camptothecin conjugate, given as an intravenous infusion once every three weeks to patients with advanced solid tumors
- (2012) E. A. Sausville et al. MOLECULAR CANCER THERAPEUTICS
- Vascular permeability in cancer and infection as related to macromolecular drug delivery, with emphasis on the EPR effect for tumor-selective drug targeting
- (2012) Hiroshi MAEDA PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
- Cathepsin X in serum from patients with colorectal cancer: relation to prognosis
- (2012) Tjasa Vizin et al. Radiology and Oncology
- Paclitaxel poliglumex for ovarian cancer
- (2011) Vijaya L Galic et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice
- (2011) Aarthi Gopinathan et al. GUT
- Biodegradable star HPMA polymer–drug conjugates: Biodegradability, distribution and anti-tumor efficacy
- (2011) Tomáš Etrych et al. JOURNAL OF CONTROLLED RELEASE
- Magnitude of Enhanced Permeability and Retention Effect in Tumors with Different Phenotypes: 89Zr-Albumin as a Model System
- (2011) C. Heneweer et al. JOURNAL OF NUCLEAR MEDICINE
- Nanomedicine(s) under the Microscope
- (2011) Ruth Duncan et al. MOLECULAR PHARMACEUTICS
- Detection of cathepsin B, cathepsin L, cystatin C, urokinase plasminogen activator and urokinase plasminogen activator receptor in the sera of lung cancer patients
- (2011) QINGYONG CHEN et al. Oncology Letters
- EPR effect based drug design and clinical outlook for enhanced cancer chemotherapy
- (2010) Hiroshi Maeda et al. ADVANCED DRUG DELIVERY REVIEWS
- The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect
- (2010) Jun Fang et al. ADVANCED DRUG DELIVERY REVIEWS
- Tumor-Selective Delivery of Macromolecular Drugs via the EPR Effect: Background and Future Prospects
- (2010) Hiroshi Maeda BIOCONJUGATE CHEMISTRY
- Comparative Biodistribution of PAMAM Dendrimers and HPMA Copolymers in Ovarian-Tumor-Bearing Mice
- (2010) S. Sadekar et al. BIOMACROMOLECULES
- Paclitaxel-Hyaluronic Acid for Intravesical Therapy of Bacillus Calmette-Guérin Refractory Carcinoma In Situ of the Bladder: Results of a Phase I Study
- (2010) P.F. Bassi et al. JOURNAL OF UROLOGY
- Development of HPMA copolymer–anticancer conjugates: Clinical experience and lessons learnt
- (2009) Ruth Duncan ADVANCED DRUG DELIVERY REVIEWS
- PEG conjugates in clinical development or use as anticancer agents: An overview
- (2009) Gianfranco Pasut et al. ADVANCED DRUG DELIVERY REVIEWS
- Elevating Blood Pressure as a Strategy to Increase Tumor-targeted Delivery of Macromolecular Drug SMANCS: Cases of Advanced Solid Tumors
- (2009) Akinori Nagamitsu et al. JAPANESE JOURNAL OF CLINICAL ONCOLOGY
- Predictors of Competing Mortality in Advanced Head and Neck Cancer
- (2009) Loren K. Mell et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase III Trial Comparing Paclitaxel Poliglumex (CT-2103, PPX) in Combination with Carboplatin Versus Standard Paclitaxel and Carboplatin in the Treatment of PS 2 Patients with Chemotherapy-Naïve Advanced Non-small Cell Lung Cancer
- (2009) Corey J. Langer et al. Journal of Thoracic Oncology
- Biodistribution of HPMA Copolymer-Aminohexylgeldanamycin-RGDfK Conjugates for Prostate Cancer Drug Delivery
- (2009) Mark P. Borgman et al. MOLECULAR PHARMACEUTICS
- Polymer-drug conjugates: Recent development in clinical oncology
- (2008) Chun Li et al. ADVANCED DRUG DELIVERY REVIEWS
- Image-guided and passively tumour-targeted polymeric nanomedicines for radiochemotherapy
- (2008) T Lammers et al. BRITISH JOURNAL OF CANCER
- A phase II study of pegylated-camptothecin (pegamotecan) in the treatment of locally advanced and metastatic gastric and gastro-oesophageal junction adenocarcinoma
- (2008) L. C. Scott et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Clinical and Pharmacologic Study of the Novel Prodrug Delimotecan (MEN 4901/T-0128) in Patients with Solid Tumors
- (2008) S. A. Veltkamp et al. CLINICAL CANCER RESEARCH
- Novel Delivery of SN38 Markedly Inhibits Tumor Growth in Xenografts, Including a Camptothecin-11-Refractory Model
- (2008) P. Sapra et al. CLINICAL CANCER RESEARCH
- New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
- (2008) E.A. Eisenhauer et al. EUROPEAN JOURNAL OF CANCER
- Serum cathepsin B and plasma urokinase-type plasminogen activator levels in gastrointestinal tract cancers
- (2008) László Herszényi et al. EUROPEAN JOURNAL OF CANCER PREVENTION
- Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect
- (2008) H. Maeda et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- A phase II trial of paclitaxel poliglumex in recurrent or persistent ovarian or primary peritoneal cancer (EOC): A gynecologic oncology group study
- (2008) Paul Sabbatini et al. GYNECOLOGIC ONCOLOGY
- Cysteine cathepsins: Cellular roadmap to different functions
- (2007) Klaudia Brix et al. BIOCHIMIE
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