Review
Biochemistry & Molecular Biology
Sunhee Jang, Kijun Lee, Ji Hyeon Ju
Summary: Osteoarthritis (OA) is a degenerative and chronic joint disease that primarily damages joint cartilage, causing pain, swelling, and stiffness. With the aging population and increasing prevalence of obesity, the prevalence of OA is expected to rise. Recent advances in understanding the mechanisms, diagnosis, and management of OA have led to many potential therapeutic advances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rehabilitation
Nabil Mahmoud Abdel-Aal, Amal Hussein Ibrahim, Mohamed Mostafa Kotb, Alaa Abdelraheem Hussein, Hisham Mohamed Hussein
Summary: This study compared the effects of mechanical traction from different knee angles on patients with knee osteoarthritis. The results showed that traction from 90 degrees and 20 degrees of knee flexion were more effective in improving pain and physical function compared to full extension of the knee.
CLINICAL REHABILITATION
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sara Ramezanpour, Thanat Kanthawang, John Lynch, Charles E. McCulloch, Michael C. Nevitt, Thomas M. Link, Gabby B. Joseph
Summary: This study investigates the impact of sustained synovitis on the progression of knee degenerative changes. The results suggest that sustained synovitis is associated with greater progression of structural degenerative disease.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Orthopedics
C. K. Hui Mingalone, C. R. Nehme, Y. Chen, J. Liu, B. N. Longo, K. D. Garvey, S. M. Covello, H. C. Nielsen, T. James, W. C. Messner, L. Zeng
Summary: The study suggests that high glucose levels and mechanical stress have a permissive effect on the loss and degradation of articular cartilage, indicating that mechanical stress may confound the association between diabetes and osteoarthritis. A novel whole joint-in-motion culture system was used to investigate the effects of glucose and loading stress on cartilage.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tom D. Turmezei, Samantha B. Low, Simon Rupret, Graham M. Treece, Andrew H. Gee, James W. MacKay, John A. Lynch, Kenneth E. S. Poole, Neil A. Segal
Summary: Joint space mapping (JSM) of the knee using weight-bearing CT images is reproducible and feasible, showing a relationship between three-dimensional joint space width distribution and structural joint disease. Novice users can learn it reliably, and it can achieve a smallest detectable difference that is at least 50% smaller than that reported in radiography.
Article
Orthopedics
Caleb W. Grote, Matthew J. Mackay, Qinghua Lu, Xiangliang Liu, Anders R. Meyer, Jinxi Wang
Summary: This study developed a comprehensive histopathologic grading scheme for murine knee osteoarthritis (OA) that covers all-stage osteoarthritic changes in all major joint tissues. The new grading scheme showed high reproducibility and accuracy in assessing OA severity and progression. It is the first whole-joint grading scheme that includes periarticular soft-tissue ossification and is suitable for quick OA severity assessments of the entire femorotibial joint.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jaromir Jarecki, Izabela Polkowska, Waldemar Kazimierczak, Magdalena Wojciak, Ireneusz Sowa, Slawomir Dresler, Tomasz Blicharski
Summary: The aim of this study was to assess the impact of physical activity on the musculoskeletal system in an animal model of early degenerative knee joint lesions. The results showed that compared to inactive rats, active rats had decreased bone density, reduced weight of fat and muscle tissues, indicating the impact of physical activity on bone mineralization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
M. A. Hunt, J. M. Charlton, D. T. Felson, A. Liu, G. J. Chapman, A. Graffos, R. K. Jones
Summary: The study found a moderate relationship between frontal plane rearfoot angle and knee adduction moment (KAM), which was mainly influenced by frontal plane knee kinematics. Other variables did not significantly alter this relationship.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Orthopedics
Jae H. Lee, Keewon Kim, Sun G. Chung
Summary: The study found that knees with osteoarthritis exhibited differences in mechanical properties compared to other clinical parameters, showing increased intra-articular pressure and synovial stiffness. The synovium of knees with osteoarthritis stretched earlier, and intra-articular pressure characteristics could be used for clinical evaluation of the synovium.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Anesthesiology
Diana Amorim, Diana Fonseca-Rodrigues, Ana David-Pereira, Octavia Costa, Antonia Palhares Lima, Rosete Nogueira, Rute Cruz, Ana Sofia Martins, Liliana Sousa, Francisco Oliveira, Helder Pereira, Rogerio Pirraco, Antti Pertovaara, Armando Almeida, Filipa Pinto-Ribeiro
Summary: The injection of kaolin/carrageenan in the rat knee joint successfully models the physical and psychiatric features of human osteoarthritis. This experimental osteoarthritis allows for the study of disease mechanisms and evaluation of therapeutic strategies to halt disease progression at different stages.
Article
Biochemistry & Molecular Biology
Haruhisa Watanabe, Takashi Iori, Ji-Won Lee, Takashi S. S. Kajii, Aya Takakura, Ryoko Takao-Kawabata, Yoshimasa Kitagawa, Yutaka Maruoka, Tadahiro Iimura
Summary: Degenerative joint disease of the temporomandibular joints (DJD-TMJ) is characterized by orofacial pain, joint sounds, and limited jaw movements. This study investigated the potential of serum CCL5 level as a biomarker for DJD-TMJ and analyzed changes in bone metabolism rate as a predisposing factor. The results showed that DJD-TMJ subjects had significantly higher levels of serum CCL5 compared to the control subjects, especially in young individuals. This suggests that serum CCL5 level may serve as a biomarker for DJD-TMJ, and changes in bone metabolism rate may predispose individuals to this condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
Amin Mohamadi, Kaveh Momenzadeh, Aidin Masoudi, Kempland C. Walley, Kenny Ierardi, Arun Ramappa, Joseph P. DeAngelis, Ara Nazarian
Summary: This study provides a chronological overview of meniscus biomechanics research over the past forty years, highlighting the evolution and understanding of this field. From cadaveric studies in the 1970s to finite element modeling and kinematic studies in more recent decades, research has progressed and expanded, paving the way for future directions in this area of study.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Biotechnology & Applied Microbiology
Sentong Wang, Kazunori Hase, Shunsuke Kita, Shinya Ogaya
Summary: This study investigates the biomechanical changes in the knee joint during walking caused by medial meniscal radial tears associated with knee osteoarthritis (OA). The results show that larger medial meniscal radial tears are prone to high stress concentrations and an increased risk of complete meniscal rupture. Furthermore, the tears disrupt the stress-transmitting function of the meniscus, greatly increasing the likelihood of developing knee OA. Complete postmeniscectomy also leads to a significant increase in tibial cartilage load, indicating a potential risk of OA flare-ups.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Orthopedics
Ittai Shichman, Erel Ben-Ari, Ethan Sissman, Christian Oakley, Ran Schwarzkopf
Summary: This study aimed to evaluate postoperative changes in the coronal alignment of the ankle joint in patients undergoing total knee arthroplasty (TKA) for different degrees of knee deformity. The study found that there were significant changes in ankle alignment in the group with a valgus correction of 10 degrees or more. However, regardless of the degree of knee deformity correction, TKA did not result in significant changes in the tibiotalar tilt angle. These findings have important implications for assessing candidates for TKA and considering potential causes of postoperative ankle pain.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Biochemical Research Methods
Gustavo A. Orozco, Kalle Karjalainen, Eng Kuan Moo, Lauri Stenroth, Petri Tanska, Jaqueline Lourdes Rios, Teemu Tuomainen, Mikko J. Nissi, Hanna Isaksson, Walter Herzog, Rami K. Korhonen
Summary: In this study, a musculoskeletal finite element model of a rat knee joint was used to evaluate cartilage biomechanical responses during a gait cycle. The results showed that simulating anatomical and locomotion characteristics accurately estimated tissue responses such as contact pressures, stresses, strains, and fluid pressures. This approach is important for investigating the effects of gait abnormalities on the adaptation and degeneration of rat knee joint tissues and could contribute to understanding the biomechanically-driven mechanisms of osteoarthritis progression as a consequence of joint injury or obesity.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Anesthesiology
P. K. Hyldmo, M. B. Horodyski, B. P. Conrad, D. N. Dubose, J. Roislien, M. Prasarn, G. R. Rechtine, E. Soreide
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2016)
Article
Engineering, Biomedical
Friedl De Groote, Allison L. Kinney, Anil V. Rao, Benjamin J. Fregly
ANNALS OF BIOMEDICAL ENGINEERING
(2016)
Article
Emergency Medicine
Dewayne N. DuBose, Laura Ann Zdziarski, Nicole Scott, Bryan Conrad, Allyson Long, Glenn R. Rechtine, Mark L. Prasarn, MaryBeth Horodyski
JOURNAL OF EMERGENCY MEDICINE
(2016)
Article
Anesthesiology
David J. Kennedy, Ryan Mattie, Alan Scott Hamilton, Bryan Conrad, Matthew Smuck
Article
Neurosciences
Joshua Vickers, Austin Reed, Robert Decker, Bryan P. Conrad, Marissa Olegario-Nebel, Heather K. Vincent
Article
Biophysics
Nicholas A. Bianco, Carolynn Patten, Benjamin J. Fregly
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2018)
Article
Multidisciplinary Sciences
Andrew J. Meyer, Carolynn Patten, Benjamin J. Fregly
Article
Mathematical & Computational Biology
Caitlin L. Banks, Mihir M. Pai, Theresa E. McGuirk, Benjamin J. Fregly, Carolynn Patten
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2017)
Article
Engineering, Biomedical
Ilan Eskinazi, Benjamin J. Fregly
MEDICAL ENGINEERING & PHYSICS
(2018)
Article
Cell & Tissue Engineering
A. R. MacLeod, G. Serrancoli, B. J. Fregly, A. D. Toms, H. S. Gill
BONE & JOINT RESEARCH
(2018)
Article
Biophysics
Mohammad S. Shourijeh, Benjamin J. Fregly
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2020)
Article
Engineering, Biomedical
Elise C. Pegg, Jonathan Walter, Darryl D. D'Lima, Benjamin J. Fregly, Harinderjit S. Gill, David W. Murray
CLINICAL BIOMECHANICS
(2020)
Article
Ergonomics
Casey A. Myers, Weldyn Allen, Peter J. Laz, Jake Lawler-Schwartz, Bryan P. Conrad
Summary: This study used high-speed stereo radiography to assess the impact of a self-lacing system with varying lace tension on foot containment during basketball activities. The results showed that the self-lacing system significantly reduced foot-shoe motion and increased athletes' confidence and flexibility.
Article
Emergency Medicine
Per Kristian Hyldmo, MaryBeth Horodyski, Bryan P. Conrad, Sindre Aslaksen, Jo Roislien, Mark Prasarn, Glenn R. Rechtine, Eldar Soreide
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2017)
Article
Veterinary Sciences
Giovanni Tremolada, Daniel D. Lewis, Ken Luka Paragnani, Bryan P. Conrad, Stanley E. Kim, Antonio Pozzi
AMERICAN JOURNAL OF VETERINARY RESEARCH
(2017)