Dissection of Ire1 Functions Reveals Stress Response Mechanisms Uniquely Evolved in Candida glabrata

Functional Repurposing Revealed by Comparing S. pombe and S. cerevisiae Genetic Interactions

(2012) Adam Frost et al.   CELL

The impact of the unfolded protein response on human disease

(2012) Shiyu Wang et al.   JOURNAL OF CELL BIOLOGY

Convergent Evolution of Calcineurin Pathway Roles in Thermotolerance and Virulence in Candida glabrata

(2012) Ying-Lien Chen et al.   G3-Genes Genomes Genetics

Antifungal Drug Resistance: Mechanisms, Epidemiology, and Consequences for Treatment

(2011) Michael A. Pfaller   AMERICAN JOURNAL OF MEDICINE

The glycosylphosphatidylinositol-linked aspartyl protease Yps1 is transcriptionally regulated by the calcineurin-Crz1 and Slt2 MAPK pathways in Candida glabrata

(2011) Taiga Miyazaki et al.   FEMS YEAST RESEARCH

Attenuation of yeast UPR is essential for survival and is mediated byIRE1kinase

(2011) Aditi Chawla et al.   JOURNAL OF CELL BIOLOGY

Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity

(2011) Claudia Rubio et al.   JOURNAL OF CELL BIOLOGY

The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway

(2011) G. Thibault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved RNA structures in the non-canonical Hac1/Xbp1 intron

(2011) Katarzyna B. Hooks et al.   RNA Biology

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response

(2011) B. M. Gardner et al.   SCIENCE

The virulence of the opportunistic fungal pathogenAspergillus fumigatusrequires cooperation between the endoplasmic reticulum-associated degradation pathway (ERAD) and the unfolded protein response (UPR)

(2011) Daryl L. Richie et al.   Virulence

Host Iron Withholding Demands Siderophore Utilization for Candida glabrata to Survive Macrophage Killing

(2011) Tracy Nevitt et al.   PLoS Pathogens

Unique Evolution of the UPR Pathway with a Novel bZIP Transcription Factor, Hxl1, for Controlling Pathogenicity of Cryptococcus neoformans

(2011) Seon Ah Cheon et al.   PLoS Pathogens

HacA-Independent Functions of the ER Stress Sensor IreA Synergize with the Canonical UPR to Influence Virulence Traits in Aspergillus fumigatus

(2011) Xizhi Feng et al.   PLoS Pathogens

Roles of Calcineurin and Crz1 in Antifungal Susceptibility and Virulence of Candida glabrata

(2010) T. Miyazaki et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Surveillance Pathway Monitors the Fitness of the Endoplasmic Reticulum to Control Its Inheritance

(2010) Anna Babour et al.   CELL

Echinocandin and triazole antifungal susceptibility profiles for Candida spp., Cryptococcus neoformans, and Aspergillus fumigatus: application of new CLSI clinical breakpoints and epidemiologic cutoff values to characterize resistance in the SENTRY Antimicrobial Surveillance Program (2009)

(2010) Michael A. Pfaller et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Role of the Slt2 mitogen-activated protein kinase pathway in cell wall integrity and virulence in Candida glabrata

(2010) Taiga Miyazaki et al.   FEMS YEAST RESEARCH

The Activity of Yeast Hog1 MAPK Is Required during Endoplasmic Reticulum Stress Induced by Tunicamycin Exposure

(2010) Francisco Torres-Quiroz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of basal cellular physiology by the homeostatic unfolded protein response

(2010) D. Thomas Rutkowski et al.   JOURNAL OF CELL BIOLOGY

The HAC1 gene from Pichia pastoris: characterization and effect of its overexpression on the production of secreted, surface displayed and membrane proteins

(2010) Mouna Guerfal et al.   Microbial Cell Factories

Functional characterization of the unconventional splicing of Yarrowia lipolytica HAC1 mRNA induced by unfolded protein response

(2010) Mi Hee Oh et al.   YEAST

An Extensive Circuitry for Cell Wall Regulation in Candida albicans

(2010) Jill R. Blankenship et al.   PLoS Pathogens

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Signalling Pathways in the Unfolded Protein Response: Development from Yeast to Mammals

(2009) K. Mori   JOURNAL OF BIOCHEMISTRY

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

A Role for the Unfolded Protein Response (UPR) in Virulence and Antifungal Susceptibility in Aspergillus fumigatus

(2009) Daryl L. Richie et al.   PLoS Pathogens

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

(2008) Kenneth P.K. Lee et al.   CELL

Nonapoptotic Death ofSaccharomyces cerevisiaeCells That Is Stimulated by Hsp90 and Inhibited by Calcineurin and Cmk2 in Response to Endoplasmic Reticulum Stresses

(2008) Drew D. Dudgeon et al.   EUKARYOTIC CELL

Impact of the unfolded protein response upon genome-wide expression patterns, and the role of Hac1 in the polarized growth, of Candida albicans

(2008) Tithira T. Wimalasena et al.   FUNGAL GENETICS AND BIOLOGY

The Unfolded Protein Response Is Induced by the Cell Wall Integrity Mitogen-activated Protein Kinase Signaling Cascade and Is Required for Cell Wall Integrity in Saccharomyces cerevisiae

(2008) Thomas Scrimale et al.   MOLECULAR BIOLOGY OF THE CELL

The unfolded protein response signals through high-order assembly of Ire1

(2008) Alexei V. Korennykh et al.   NATURE

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY