Nitazoxanide Stimulates Autophagy and Inhibits mTORC1 Signaling and Intracellular Proliferation of Mycobacterium tuberculosis

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

(2014) Daniel J. Klionsky et al.   Autophagy

Synergistic Drug Combinations for Tuberculosis Therapy Identified by a Novel High-Throughput Screen

(2011) Santiago Ramón-García et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Autophagy and p62/sequestosome 1 generate neo-antimicrobial peptides (cryptides) from cytosolic proteins

(2011) Marisa Ponpuak et al.   Autophagy

Persistent expression of Nqo1 by p62-mediated Nrf2 activation facilitates p53-dependent mitotic catastrophe

(2011) Chi-Bao Bui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A delicate dance: host response to mycobacteria

(2011) Kassidy K Huynh et al.   CURRENT OPINION IN IMMUNOLOGY

Identification of a host cell target for the thiazolide class of broad-spectrum anti-parasitic drugs

(2011) Joachim Müller et al.   EXPERIMENTAL PARASITOLOGY

The challenge of new drug discovery for tuberculosis

(2011) Anil Koul et al.   NATURE

Manipulation of host membranes by bacterial effectors

(2011) Hyeilin Ham et al.   NATURE REVIEWS MICROBIOLOGY

Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H+-ATPase to inhibit phagosome acidification

(2011) D. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector

(2010) Albena T. Dinkova-Kostova et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Synthesis and Antimicrobial Evaluation of Nitazoxanide-Based Analogues: Identification of Selective and Broad Spectrum Activity

(2010) T. Eric Ballard et al.   ChemMedChem

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Bfl-1/A1 acts as a negative regulator of autophagy in mycobacteria infected macrophages

(2010) Mahesh Kathania et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Antioxidant Transcription Factor Nrf2 Negatively Regulates Autophagy and Growth Arrest Induced by the Anticancer Redox Agent Mitoquinone

(2010) V. Ashutosh Rao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hijacked phagosomes and leukocyte activation: an intimate relationship

(2010) Abdoulaye Oury Barry et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin inhibits mTORC1, but not completely

(2009) Carson C. Thoreen et al.   Autophagy

A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1

(2009) Jingxiang Huang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Protein kinase and phosphatase signaling in Mycobacterium tuberculosis physiology and pathogenesis

(2009) Joseph Chao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Ubiquitin-independent p53 proteasomal degradation

(2009) P Tsvetkov et al.   CELL DEATH AND DIFFERENTIATION

Autophagy, Immunity, and Microbial Adaptations

(2009) Vojo Deretic et al.   Cell Host & Microbe

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitazoxanide Kills Replicating and NonreplicatingMycobacterium tuberculosisand Evades Resistance

(2009) Luiz Pedro S. de Carvalho et al.   JOURNAL OF MEDICINAL CHEMISTRY

Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway

(2009) Hui H. Zhang et al.   PLoS One

Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling

(2009) Aruna D. Balgi et al.   PLoS One

New Insights into mTOR Signaling: mTORC2 and Beyond

(2009) D. R. Alessi et al.   Science Signaling

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

ATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes/macrophages

(2008) Debasis Biswas et al.   BMC IMMUNOLOGY

Glutathione S-Transferase P1: Gene Sequence Variation and Functional Genomic Studies

(2008) A. M. Moyer et al.   CANCER RESEARCH

Mycobacterium tuberculosis Virulence Is Mediated by PtpA Dephosphorylation of Human Vacuolar Protein Sorting 33B

(2008) Horacio Bach et al.   Cell Host & Microbe

Thiazolides inhibit growth and induce glutathione-S-transferase Pi (GSTP1)-dependent cell death in human colon cancer cells

(2008) Joachim Müller et al.   INTERNATIONAL JOURNAL OF CANCER

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

(2008) Michael Degtyarev et al.   JOURNAL OF CELL BIOLOGY

Successful treatment of niclosamide- and praziquantel-resistant beef tapeworm infection with nitazoxanide

(2007) Mohammad Lateef et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES