Metabolism of Phosphatidylinositol 4-Kinase IIIα-Dependent PI4P Is Subverted by HCV and Is Targeted by a 4-Anilino Quinazoline with Antiviral Activity

Discovery of Potent Hepatitis C Virus NS5A Inhibitors with Dimeric Structures

(2011) Julie A. Lemm et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Osh Proteins Regulate Phosphoinositide Metabolism at ER-Plasma Membrane Contact Sites

(2011) Christopher J. Stefan et al.   CELL

Recruitment and Activation of a Lipid Kinase by Hepatitis C Virus NS5A Is Essential for Integrity of the Membranous Replication Compartment

(2011) Simon Reiss et al.   Cell Host & Microbe

Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in Humans: In Vitro and In Vivo Correlations

(2011) Robert A. Fridell et al.   HEPATOLOGY

Hepatitis C Virus NS5A Protein Interacts with Phosphatidylinositol 4-Kinase Type IIIα and Regulates Viral Propagation

(2011) Yun-Sook Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis C Virus Stimulates the Phosphatidylinositol 4-Kinase III Alpha-Dependent Phosphatidylinositol 4-Phosphate Production That Is Essential for Its Replication

(2011) K. L. Berger et al.   JOURNAL OF VIROLOGY

Multifaceted roles for lipids in viral infection

(2011) Nicholas S. Heaton et al.   TRENDS IN MICROBIOLOGY

Development of novel therapies for hepatitis C

(2010) Stanley M. Lemon et al.   ANTIVIRAL RESEARCH

Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication

(2010) Nai-Yun Hsu et al.   CELL

New HCV therapies on the horizon

(2010) J. Vermehren et al.   CLINICAL MICROBIOLOGY AND INFECTION

Role of Annexin A2 in the Production of Infectious Hepatitis C Virus Particles

(2010) P. Backes et al.   JOURNAL OF VIROLOGY

Phosphatidylinositol 4-Kinase III Beta Is a Target of Enviroxime-Like Compounds for Antipoliovirus Activity

(2010) M. Arita et al.   JOURNAL OF VIROLOGY

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

(2010) Min Gao et al.   NATURE

SCY-635, a Novel Nonimmunosuppressive Analog of Cyclosporine That Exhibits Potent Inhibition of Hepatitis C Virus RNA Replication In Vitro

(2009) S. Hopkins et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Domain 3 of non-structural protein 5A from hepatitis C virus is natively unfolded

(2009) Xavier Hanoulle et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4Pand PtdIns(4,5)P2

(2009) Gerald R. V. Hammond et al.   BIOCHEMICAL JOURNAL

Synthesis and SAR of piperazinyl-N-phenylbenzamides as inhibitors of hepatitis C virus RNA replication in cell culture

(2009) Immacolata Conte et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Functional Genomic Screen Identifies Cellular Cofactors of Hepatitis C Virus Replication

(2009) Andrew W. Tai et al.   Cell Host & Microbe

Domain III of NS5A contributes to both RNA replication and assembly of hepatitis C virus particles

(2009) M. Hughes et al.   JOURNAL OF GENERAL VIROLOGY

Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus Replication

(2009) J. Borawski et al.   JOURNAL OF VIROLOGY

Identification of Hepatitis C Virus NS5A Inhibitors

(2009) J. A. Lemm et al.   JOURNAL OF VIROLOGY

Role of Oxysterol Binding Protein in Hepatitis C Virus infection

(2009) Y. Amako et al.   JOURNAL OF VIROLOGY

Naturally Occurring Hepatitis C Virus Subgenomic Deletion Mutants Replicate Efficiently in Huh-7 Cells and Are trans-Packaged In Vitro To Generate Infectious Defective Particles

(2009) L. Pacini et al.   JOURNAL OF VIROLOGY

Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus

(2009) R. A. Love et al.   JOURNAL OF VIROLOGY

Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication

(2009) K. L. Berger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replication

(2009) Frédéric H. Vaillancourt et al.   VIROLOGY

The multiple roles of PtdIns(4)P - not just the precursor of PtdIns(4,5)P2

(2008) G. D'Angelo et al.   JOURNAL OF CELL SCIENCE

Modification of intracellular membrane structures for virus replication

(2008) Sven Miller et al.   NATURE REVIEWS MICROBIOLOGY

Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle Assembly

(2008) Nicole Appel et al.   PLoS Pathogens

Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A Protein

(2008) Timothy L. Tellinghuisen et al.   PLoS Pathogens

Maintenance of Hormone-sensitive Phosphoinositide Pools in the Plasma Membrane Requires Phosphatidylinositol 4-Kinase IIIα

(2007) Andras Balla et al.   MOLECULAR BIOLOGY OF THE CELL