期刊
PLOS PATHOGENS
卷 7, 期 2, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.ppat.1001293
关键词
-
资金
- Vaccine Research Center (VRC)
- National Institute of Allergy and Infectious Diseases (NIAID)
- Center for HIV/AIDS Vaccine Immunology (CHAVI) [AI067854]
We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood-and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. At the time of peak virus replication, SIV sequences were intermixed between the blood and semen supporting a scenario of high-level virus spillover into the male genital tract. However, at the time of virus set point, compartmentalization was apparent in 4 of 7 evaluated monkeys, likely as a consequence of restricted virus gene flow between anatomic compartments after the resolution of primary viremia. These findings suggest that SIV replication in the male genital tract evolves to compartmentalization after peak viremia resolves.
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