Structural and Functional Analysis of Laninamivir and its Octanoate Prodrug Reveals Group Specific Mechanisms for Influenza NA Inhibition

Inhibitor selectivity of a new class of oseltamivir analogs against viral neuraminidase over human neuraminidase enzymes

(2011) Amgad Albohy et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Special features of the 2009 pandemic swine-origin influenza A H1N1 hemagglutinin and neuraminidase

(2011) Christopher John Vavricka et al.   CHINESE SCIENCE BULLETIN

Frequency of Drug-resistant Viruses and Virus Shedding in Pediatric Influenza Patients Treated With Neuraminidase Inhibitors

(2011) Daisuke Tamura et al.   CLINICAL INFECTIOUS DISEASES

Novel neuraminidase inhibitors: identification, biological evaluation and investigations of the binding mode

(2011) Johannes Kirchmair et al.   Future Medicinal Chemistry

Influenza A Virus N5 Neuraminidase Has an Extended 150-Cavity

(2011) M. Wang et al.   JOURNAL OF VIROLOGY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Laninamivir Prodrug CS-8958, a Long-Acting Neuraminidase Inhibitor, Shows Superior Anti-Influenza Virus Activity after a Single Administration

(2010) S. Kubo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Long-Acting Neuraminidase Inhibitor Laninamivir Octanoate (CS-8958) versus Oseltamivir as Treatment for Children with Influenza Virus Infection

(2010) N. Sugaya et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Long‐Acting Neuraminidase Inhibitor Laninamivir Octanoate versus Oseltamivir for Treatment of Influenza: A Double‐Blind, Randomized, Noninferiority Clinical Trial

(2010) Akira Watanabe et al.   CLINICAL INFECTIOUS DISEASES

Potential drug-like inhibitors of Group 1 influenza neuraminidase identified through computer-aided drug design

(2010) Jacob D. Durrant et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Influenza Hemagglutinin and Neuraminidase Membrane Glycoproteins

(2010) Steven J. Gamblin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical Pharmacokinetics of Laninamivir, a Novel Long-Acting Neuraminidase Inhibitor, After Single and Multiple Inhaled Doses of Its Prodrug, CS-8958, in Healthy Male Volunteers

(2010) Hitoshi Ishizuka et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Carbocycles Related to Oseltamivir as Influenza Virus Group-1-Specific Neuraminidase Inhibitors. Binding to N1 Enzymes in the Context of Virus-like Particles

(2010) Sankar Mohan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective Binding of Antiinfluenza Drugs and Their Analogues to ‘Open’ and ‘Closed’ Conformations of H5N1 Neuraminidase

(2010) Pei Wang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site

(2010) Qing Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Emergence of a Multidrug-Resistant Pandemic Influenza A (H1N1) Virus

(2010) Erhard van der Vries et al.   NEW ENGLAND JOURNAL OF MEDICINE

It is not just AIV: From avian to swine-origin influenza virus

(2010) George F. Gao et al.   Science China-Life Sciences

Pharmacokinetics and disposition of CS-8958, a long-acting prodrug of the novel neuraminidase inhibitor laninamivir in rats

(2010) K. Koyama et al.   XENOBIOTICA

Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase

(2010) Santosh Rudrawar et al.   Nature Communications

Efficacy of the New Neuraminidase Inhibitor CS-8958 against H5N1 Influenza Viruses

(2010) Maki Kiso et al.   PLoS Pathogens

Flu channel drug resistance: a tale of two sites

(2010) Rafal M. Pielak et al.   Protein & Cell

Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus

(2010) Wei Zhang et al.   Protein & Cell

Unraveling the Mystery of Swine Influenza Virus

(2009) Taia T. Wang et al.   CELL

Synthetic Approaches to the Neuraminidase Inhibitors Zanamivir (Relenza) and Oseltamivir Phosphate (Tamiflu) for the Treatment of Influenza

(2009) Javier Magano   CHEMICAL REVIEWS

Antiviral Potential and Molecular Insight into Neuraminidase Inhibiting Diarylheptanoids fromAlpinia katsumadai

(2009) Ulrike Grienke et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterizing Loop Dynamics and Ligand Recognition in Human- and Avian-Type Influenza Neuraminidases via Generalized Born Molecular Dynamics and End-Point Free Energy Calculations

(2009) Rommie E. Amaro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

CS-8958, a Prodrug of the New Neuraminidase Inhibitor R-125489, Shows Long-Acting Anti-Influenza Virus Activity

(2008) M. Yamashita et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel Druggable Hot Spots in Avian Influenza Neuraminidase H5N1 Revealed by Computational Solvent Mapping of a Reduced and Representative Receptor Ensemble

(2008) Melissa R. Landon et al.   Chemical Biology & Drug Design

Structural Characterization of the 1918 Influenza Virus H1N1 Neuraminidase

(2008) X. Xu et al.   JOURNAL OF VIROLOGY

Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants

(2008) Patrick J. Collins et al.   NATURE