Article
Microbiology
Lacie M. M. Werner, Allison Alcott, Frida Mohlin, Jocelyn C. C. Ray, Meagan Belcher Dufrisne, Asya Smirnov, Linda Columbus, Anna M. M. Blom, Alison K. K. Criss
Summary: Gonorrhea is a major public health issue, and understanding how N. gonorrhoeae survives and persists is crucial. This study reveals that human serum, specifically C4b-binding protein, enhances the survival of Opa+ N. gonorrhoeae by suppressing neutrophil defenses.
Article
Virology
James M. Readler, Meghan R. Burke, Priyanka Sharma, Katherine J. D. A. Excoffon, Abimbola O. Kolawole
Summary: Human adenoviruses (HAdV) can cause various infections, and neutrophils enhance viral transmission in epithelial cells. In this study, neutrophil serine proteases were found to be critical for neutrophil-enhanced epithelial cell infection. Additionally, neutrophil elastase could activate autophagy in epithelial cells, leading to increased viral transmission.
Article
Immunology
Laila Ferrera, Hanane Rogua, Nezha El Mansouri, Farid Kassidi, Mohamed Aksim, Abdallah El Farouqi, Said Chouham, Mohamed Nejmeddine
Summary: This study aims to assess the prevalence and possible risk factors of Chlamydia trachomatis (CT) and human papillomavirus (HPV)/CT co-infection in women from South of Morocco. The results showed that CT and HPV/CT co-infection were associated with an increased risk of developing cervical pathogenesis. Co-infection was also found to be associated with an increased risk of developing cervical abnormalities.
MICROBIAL PATHOGENESIS
(2023)
Article
Immunology
Chunyan Zhong, Xinzheng Li, Yong Teng, Jiyun Tian
Summary: This study investigated the prevalence of HPV, STIs, and their co-infections on different genders and ages. The results showed that there were significant differences in the distribution of HPV subtypes between different genders. Females were more susceptible to HR-HPV 52 and 31, while males were more susceptible to LR-HPV 6 and 11. Additionally, younger patients had a higher incidence of STIs. Patients with HPV infections, regardless of gender, had a higher incidence of Chlamydia trachomatis (CT).
MICROBIAL PATHOGENESIS
(2023)
Article
Immunology
Xiaohong Su, Wenjing Le, Xiaofeng Zhu, Sai Li, Baoxi Wang, Guillermo Madico, Zhaoyan Yang, Christine E. Chaisson, Robert E. McLaughlin, Sumanth Gandra, Jungwon Yoon, Bo Zheng, Lisa A. Lewis, Sunita Gulati, George W. Reed, Sanjay Ram, Peter A. Rice
Summary: This study compared the exposure of female partners to male gonococcal burdens in infected versus uninfected partners. The findings showed that gonococcal infections in women were more frequent when their partners had higher burdens of infection. Additionally, co-infection with Chlamydia was also associated with increased gonococcal burdens in women.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Infectious Diseases
Margaret R. Hammerschlag, Roopali Sharma
Summary: Azithromycin is less effective than doxycycline in treating rectal infections, with further research needed to explore treatment options and dosages.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2021)
Article
Immunology
Delia Onorini, Nicole Borel, Robert V. Schoborg, Cory Ann Leonard
Summary: Chlamydia trachomatis and Neisseria gonorrhoeae are the most common bacterial sexually transmitted infections worldwide, often co-infecting and showing that Ng co-infection reduces susceptibility and development of Ct infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Phuong Thi Thu Nguyen, Ha Viet Pham, Dung Hoang Van, Linh Van Pham, Hoi Thanh Nguyen, Hung Van Nguyen
Summary: In this study, the safety and efficacy of two treatment regimens for co-infection of gonorrhea and chlamydia were compared. The results showed that ceftriaxone plus doxycycline was superior to cefixime plus doxycycline in treating the co-infection. The safety profiles of the two regimens were similar.
BMC INFECTIOUS DISEASES
(2022)
Article
Immunology
Yating Wen, Fangzhen Luo, Lanhua Zhao, Shengmei Su, Wenbo Lei, Yi Liu, Keliang Shi, Zhongyu Li
Summary: During Ct infection, upregulating FGD5-AS1 affects DNA replication and apoptosis of host cells through the Wnt/beta-catenin pathway, indicating the involvement of lncRNAs in the interaction between Ct and hosts.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Oncology
Seyed-Abolfazl Hosseininasab-nodoushan, Kiarash Ghazvini, Tannaz Jamialahmadi, Masoud Keikha, Amirhossein Sahebkar
Summary: This study confirmed the clinical relevance of Chlamydia and Mycoplasma infection in the development of ovarian cancer risk, although the significance was marginal and study heterogeneity was significant. Further studies in this area are needed.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biology
Simone Filardo, Marisa Di Pietro, Federica Frasca, Fabiana Diaco, Mirko Scordio, Guido Antonelli, Carolina Scagnolari, Rosa Sessa
Summary: The study found that IFN-gamma inhibits the inflammasome network in C. trachomatis-infected synovial cells by downregulating caspase-1 mRNA expression, revealing how the bacterium hinders the inflammasome pathway for intracellular survival.
Article
Immunology
Simone da Silva Goes, Ricardo Roberto de Souza Fonseca, Maria Eduarda de Sousa Avelino, Sandra Souza Lima, Misma Suely Goncalves Araujo de Lima, Rogerio Valois Laurentino, Maria Alice Freitas Queiroz, Felipe Bonfim Freitas, Antonio Carlos Rosario Vallinoto, Ricardo Ishak, Luiz Fernando Almeida Machado
Summary: This study examines the seroprevalence of Chlamydia trachomatis infection among newly diagnosed HIV patients in Belem, Para, Brazil. The results show a high rate of exposure to C. trachomatis in this population, emphasizing the importance of screening for C. trachomatis in all HIV patients.
Article
Biology
Xiaotian Tang, Yongguo Cao, Gunjan Arora, Jesse Hwang, Andaleeb Sajid, Courtney L. Brown, Sameet Mehta, Alejandro Marin-Lopez, Yu-Min Chuang, Ming-Jie Wu, Hongwei Ma, Utpal Pal, Sukanya Narasimhan, Erol Fikrig
Summary: This study identified that ticks carry an adiponectin receptor-like protein (ISARL) but lack adiponectin, suggesting activation by alternative pathways. The ISARL signaling may be co-opted by the Lyme disease agent, as its expression is significantly upregulated in the tick gut after Borrelia burgdorferi infection.
Review
Biochemistry & Molecular Biology
Guangming Zhong
Summary: Research findings suggest that Chlamydia trachomatis plays a significant role in genital tract pathogenicity but can also colonize the gastrointestinal tract for extended periods. Plasmid and chromosome-encoded factors have varying importance in colonization of different parts of the GI tract, playing crucial roles in the spread and colonization of Chlamydia.
TRENDS IN MICROBIOLOGY
(2021)
Article
Biology
Chathuranga L. Fonseka, Clare S. Hardman, Jeongmin Woo, Randeep Singh, Janina Nahler, Jiahe Yang, Yi-Ling Chen, Achala Kamaladasa, Tehani Silva, Maryam Salimi, Nicki Gray, Tao Dong, Gathsaurie N. Malavige, Graham S. Ogg
Summary: Group 2 innate lymphoid cells are activated during acute dengue viral infection in humans and play a role in facilitating viral dissemination through downregulation of type I-IFN responsive gene and protein expression via prostaglandin D2. They also enhance monocyte infection and can be targeted for therapeutic intervention.
COMMUNICATIONS BIOLOGY
(2022)