A Major Determinant of Cyclophilin Dependence and Cyclosporine Susceptibility of Hepatitis C Virus Identified by a Genetic Approach

Development of a Cell-Based Hepatitis C Virus Infection Fluorescent Resonance Energy Transfer Assay for High-Throughput Antiviral Compound Screening

(2009) X. Yu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

SCY-635, a Novel Nonimmunosuppressive Analog of Cyclosporine That Exhibits Potent Inhibition of Hepatitis C Virus RNA Replication In Vitro

(2009) S. Hopkins et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

HCV genotype 1b chimeric replicon with NS5B of JFH-1 exhibited resistance to cyclosporine A

(2009) Ken-ichi Abe et al.   ARCHIVES OF VIROLOGY

Identification of cellular and viral factors related to anti-hepatitis C virus activity of cyclophilin inhibitor

(2009) Kaku Goto et al.   CANCER SCIENCE

A Functional Genomic Screen Identifies Cellular Cofactors of Hepatitis C Virus Replication

(2009) Andrew W. Tai et al.   Cell Host & Microbe

Towards a small animal model for hepatitis C

(2009) Alexander Ploss et al.   EMBO REPORTS

Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening

(2009) Maud Trotard et al.   FASEB JOURNAL

The cyclophilin inhibitor Debio 025 combined with PEG IFNα2a significantly reduces viral load in treatment-naïve hepatitis C patients

(2009) Robert Flisiak et al.   HEPATOLOGY

Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A

(2009) Sandra Ciesek et al.   HEPATOLOGY

Mutations in the hepatitis C virus polymerase that increase RNA binding can confer resistance to cyclosporine A

(2009) Zhe Liu et al.   HEPATOLOGY

Hepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolylcis/transIsomerase Activity of Cyclophilins A and B

(2009) Xavier Hanoulle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Isomerase Active Site of Cyclophilin A Is Critical for Hepatitis C Virus Replication

(2009) Udayan Chatterji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus Replication

(2009) J. Borawski et al.   JOURNAL OF VIROLOGY

A Conserved Proline between Domains II and III of Hepatitis C Virus NS5A Influences both RNA Replication and Virus Assembly

(2009) M. Hughes et al.   JOURNAL OF VIROLOGY

The Tight Junction-Associated Protein Occludin Is Required for a Postbinding Step in Hepatitis C Virus Entry and Infection

(2009) I. Benedicto et al.   JOURNAL OF VIROLOGY

Critical Role of Cyclophilin A and Its Prolyl-Peptidyl Isomerase Activity in the Structure and Function of the Hepatitis C Virus Replication Complex

(2009) Z. Liu et al.   JOURNAL OF VIROLOGY

Human occludin is a hepatitis C virus entry factor required for infection of mouse cells

(2009) Alexander Ploss et al.   NATURE

Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication

(2009) K. L. Berger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A genome-wide genetic screen for host factors required for hepatitis C virus propagation

(2009) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replication

(2009) Frédéric H. Vaillancourt et al.   VIROLOGY

A single point mutation in E2 enhances hepatitis C virus infectivity and alters lipoprotein association of viral particles

(2009) Wanyin Tao et al.   VIROLOGY

Multiple cyclophilins involved in different cellular pathways mediate HCV replication

(2009) L. Alex Gaither et al.   VIROLOGY

Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics

(2009) Artur Kaul et al.   PLoS Pathogens

Combinations of Cyclophilin Inhibitor NIM811 with Hepatitis C Virus NS3-4A Protease or NS5B Polymerase Inhibitors Enhance Antiviral Activity and Suppress the Emergence of Resistance

(2008) J. E. Mathy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Development of a replicon-based phenotypic assay for assessing the drug susceptibilities of HCV NS3 protease genes from clinical isolates

(2008) Xiaoping Qi et al.   ANTIVIRAL RESEARCH

Cyclophilin A Is an Essential Cofactor for Hepatitis C Virus Infection and the Principal Mediator of Cyclosporine Resistance In Vitro

(2008) F. Yang et al.   JOURNAL OF VIROLOGY

Tight Junction Proteins Claudin-1 and Occludin Control Hepatitis C Virus Entry and Are Downregulated during Infection To Prevent Superinfection

(2008) S. Liu et al.   JOURNAL OF VIROLOGY