Article
Multidisciplinary Sciences
Romano Strobelt, Julia Adler, Nir Paran, Yfat Yahalom-Ronen, Sharon Melamed, Boaz Politi, Ziv Shulman, Dominik Schmiedel, Yosef Shaul
Summary: The drug imatinib has been found to robustly decrease SARS-CoV-2 infection by inhibiting the viral entry process. It acts through a non-target mechanism by inhibiting membrane fusion and endocytosis of the virus, making it a promising therapeutic drug for COVID-19.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Jinhui Wang, Pik Ki Lau, Chun Wa Li, Yusong Guo
Summary: This study investigates the mechanisms of how newly synthesized EGFR is transported from the trans-Golgi network (TGN) to the cell surface. The researchers identify that the clathrin adaptor complex-1 (AP-1) and Rab12 interact with EGFR and regulate its export from the TGN. They also find that a specific tyrosine residue on EGFR is critical for binding to AP-1 and for TGN export. Moreover, AP-1 and Rab12 are shown to be important for EGFR signaling and cellular functions. The study provides insights into the molecular mechanisms underlying EGFR transport and highlights the role of AP-1 and Rab12 in EGFR trafficking.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Cell Biology
Xinyue Huang, Shuixia Tan, Yanxia Li, Shuangyi Cao, Xingyan Li, Heling Pan, Bing Shan, Lihui Qian, Junying Yuan
Summary: Our study reveals a biphasic model of the role of RIPK1 in mediating proinflammatory cytokine production, with distinct temporal roles when caspases are inhibited. Early phase production is NF-κB pathway-mediated and scaffold-dependent, while late phase involves the formation of a novel complex with key signaling mediators. RIPK1 kinase inhibitor Nec-1s can block late phase cytokine production, demonstrating a mechanism for the regulation of inflammatory signaling.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
M. J. Yanez, F. Campos, T. Marin, A. D. Klein, A. H. Futerman, A. R. Alvarez, S. Zanlungo
Summary: This study reveals that c-Abl tyrosine kinase participates upstream of RIPK3 in Gaucher disease, with its inhibition showing potential therapeutic benefits. The interaction and phosphorylation of RIPK3 by c-Abl was reduced with pharmacological intervention, highlighting c-Abl signaling as a novel pathway for potential GD treatment.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Multidisciplinary Sciences
R. C. Nayak, K. H. Chang, A. K. Singh, M. Kotliar, M. Desai, A. M. Wellendorf, M. Wunderlich, J. Bartram, B. Mizukawa, M. Cuadrado, P. Dexheimer, A. Barski, X. R. Bustelo, N. N. Nassar, J. A. Cancelas
Summary: This study investigates the function of leukemic VAV3 in Ph+ and Ph-like B-ALL and reveals that nuclear VAV3 controls repressive transcriptional activity through the AKT/PHLPP2-BMI1 pathway. The findings highlight the importance of non-canonical nuclear Rho GTPase signaling in leukemogenesis.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Henriette Rubsam, Christina Kronauer, Nikolaj B. Abel, Hongtao Ji, Damiano Lironi, Simon B. Hansen, Marcin Nadzieja, Marie Kolte, Dorte Abel, Noor de Jong, Lene H. Madsen, Huijun Liu, Jens Stougaard, Simona Radutoiu, Kasper R. Andersen
Summary: This study developed a synthetic approach using nanobodies to understand and activate multicomponent receptor complexes, successfully manipulating receptors involved in plant symbiosis with nitrogen-fixing bacteria. The authors found that the Lotus japonicus Nod factor receptors NFR1 and NFR5 form the core receptor complex for initiating root nodule organogenesis and controlling infection. They also discovered that organogenesis signaling is mediated by intracellular kinase domains, while infection requires functional ectodomains. Additionally, evolutionarily distant barley receptors were identified, which could potentially enable nitrogen-fixation engineering in cereals.
Review
Biochemistry & Molecular Biology
Graham M. Burkart, Federica Brandizzi
Summary: Organisms must sense and process information about the availability of nutrients, energy status, and environmental cues to identify the appropriate times for growth and development. The TOR complex in plants has evolved specific functional and mechanistic features, serving as a central hub for integrating external and internal metabolic cues.
TRENDS IN BIOCHEMICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Changxuan Xia, Guohua Liang, Kang Chong, Yunyuan Xu
Summary: Improvement of chilling tolerance is crucial in rice production and depends on the signaling network triggered by receptors, but little is known about the QTL genes encoding membrane complexes for sensing cold. In this study, the major gene COG1, which originates from Chinese O. Rufipogon and is fixed in japonica rice during domestication, is found to confer chilling tolerance in japonica rice. COG1 targets and activates the kinase OsSERL2 in a cold-induced manner, promoting chilling tolerance.
NATURE COMMUNICATIONS
(2023)
Article
Hematology
Lauren M. Brown, Soroor Hediyeh-Zadeh, Teresa Sadras, Hannah Huckstep, Jarrod J. Sandow, Ray C. Bartolo, Hansen J. Kosasih, Nadia M. Davidson, Breon Schmidt, Stefan Bjelosevic, Ricky Johnstone, Andrew Webb, Seong L. Khaw, Alicia Oshlack, Melissa J. Davis, Paul G. Ekert
Summary: This study identified a rare SFPQ-ABL1 fusion gene that plays a crucial role in cellular transformation in Ph-like ALL. Unlike other ABL1 fusion genes, SFPQ-ABL1 exhibits differences in subcellular localization, proliferative capacity, and activation of cellular pathways. These findings highlight the significance of fusion partners in mediating the function of ABL1 fusion genes.
Article
Multidisciplinary Sciences
Victoria H. Ng, Zachary Spencer, Leif R. Neitzel, Anmada Nayak, Matthew A. Loberg, Chen Shen, Sara N. Kassel, Heather K. Kroh, Zhenyi An, Christin C. Anthony, Jamal M. Bryant, Amanda Lawson, Lily Goldsmith, Hassina Benchabane, Amanda G. Hansen, Jingjing Li, Starina D'Souza, Andres M. Lebensohn, Rajat Rohatgi, William A. Weiss, Vivian L. Weiss, Charles Williams, Charles C. Hong, David J. Robbins, Yashi Ahmed, Ethan Lee
Summary: The study identifies the USP46 deubiquitylase complex as a positive regulator of Wnt signaling in various organisms. The complex inhibits the degradation of cell surface LRP6, thereby enhancing Wnt signaling. The authors propose a model for the assembly of the complex and its role in Wnt signaling.
NATURE COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Gustavo P. Amarante-Mendes, Aamir Rana, Tarcila Santos Datoguia, Nelson Hamerschlak, Gabriela Brumatti
Summary: The constitutively active BCR-ABL1 tyrosine kinase plays a role in leukemia and initiates a complex signaling transduction cascade. Tyrosine kinase inhibitors have revolutionized the treatment of CML, but complete cure is not achieved. Other mechanisms exist in the later stages of the disease.
Article
Biochemistry & Molecular Biology
Mirja Tamara Prentzell, Ulrike Rehbein, Marti Cadena Sandoval, Ann-Sofie De Meulemeester, Ralf Baumeister, Laura Brohee, Bianca Berdel, Mathias Bockwoldt, Bernadette Carroll, Suvagata Roy Chowdhury, Andreas von Deimling, Constantinos Demetriades, Gianluca Figlia, Mariana Eca Guimaraes de Araujo, Alexander M. Heberle, Ines Heiland, Birgit Holzwarth, Lukas A. Huber, Jacek Jaworski, Magdalena Kedra, Katharina Kern, Andrii Kopach, Viktor Korolchuk, Ineke van't Land-Kuper, Matylda Macias, Mark Nellist, Wilhelm Palm, Stefan Pusch, Jose Miguel Ramos Pittol, Michele Reil, Anja Reintjes, Friederike Reuter, Julian R. Sampson, Chloe Scheldeman, Aleksandra Siekierska, Eduard Stefan, Aurelio A. Teleman, Laura E. Thomas, Omar Torres-Quesada, Saskia Trump, Hannah D. West, Peter de Witte, Sandra Woltering, Teodor E. Yordanov, Justyna Zmorzynska, Christiane A. Opitz, Kathrin Thedieck
Summary: The study found that Ras GTPase-activating protein-binding proteins 1 and 2 are core components of stress granules and play a key role at the cytoplasmic surface of lysosomes. They anchor the tuberous sclerosis complex protein complex to lysosomes in a non-redundant manner, suppressing the activation of mTORC1. Deficiency in G3BP1 can lead to phenotypes related to mTORC1 hyperactivity, and low G3BP1 levels in tumors enhance mTORC1-driven cell motility and correlate with poor outcomes in patients. Additionally, inhibition of G3bp1 in zebrafish affects neuronal development and function.
Article
Cell Biology
Yu Zhang, Jia Liu, Dandan Yu, Xinxin Zhu, Xiaoyan Liu, Jun Liao, Sheng Li, Huayi Wang
Summary: The activation of MLKL is a sequential process, starting with the dimerization of the kinase-like domain followed by the self-assembly of the internal coiled-coil region to form a proper MLKL oligomer. The dimerization of the kinase-like domain appears to be a general step in the RIP3-induced MLKL activation process for both human and other mammalian species.
CELL DEATH & DISEASE
(2021)
Article
Developmental Biology
Xuejing Jin, Yijie Chen, Zhumei Sheng, Xue Wang, Zhifen Zhang, Jian Huang, Jie Zhou, Feiyun Lin
Summary: Research found that SKAP2 regulates the growth and migration of trophoblasts and may play an important role in missed abortion.
Article
Biology
Tomoyuki Fukuda, Fajar Sofyantoro, Yen Teng Tai, Kim Hou Chia, Takato Matsuda, Takaaki Murase, Yuichi Morozumi, Hisashi Tatebe, Tomotake Kanki, Kazuhiro Shiozaki
Summary: The GATOR2 subunit Sea3 unexpectedly attenuates TORC1 activity by being physically and functionally proximal to GATOR1 in fission yeast. The GATOR complex in fission yeast is dispensable for TORC1 regulation in response to amino acid starvation, as cells instead activate the Gcn2 pathway to inhibit TORC1 and induce autophagy.
Article
Oncology
Lucy B. Cook, Shigeo Fuji, Olivier Hermine, Ali Bazarbachi, Juan Carlos Ramos, Lee Ratner, Steve Horwitz, Paul Fields, Alina Tanase, Horia Bumbea, Kate Cwynarski, Graham Taylor, Thomas A. Waldmann, Achilea Bittencourt, Ambroise Marcais, Felipe Suarez, David Sibon, Adrienne Phillips, Matthew Lunning, Reza Farid, Yoshitaka Imaizumi, Ilseung Choi, Takashi Ishida, Kenji Ishitsuka, Takuya Fukushima, Kaoru Uchimaru, Akifumi Takaori-Kondo, Yoshiki Tokura, Atae Utsunomiya, Masao Matsuoka, Kunihiro Tsukasaki, Toshiki Watanabe
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Review
Oncology
Erin Reid, Gita Suneja, Richard F. Ambinder, Kevin Ard, Robert Baiocchi, Stefan K. Barta, Evie Carchman, Adam Cohen, Oxana V. Crysler, Neel Gupta, Chelsea Gustafson, Allison Hall, Kimberly L. Johung, Ann Klopp, Ann S. LaCasce, Chi Lin, Amitkumar Mehta, Manoj P. Menon, David Morgan, Nitya Nathwani, Ariela Noy, Lee Ratner, Stacey Rizza, Michelle A. Rudek, Julian Sanchez, Jeff Taylor, Benjamin Tomlinson, Chia-Ching J. Wang, Sai Yendamuri, Mary A. Dwyer, Deborah A. Freedman-Cass
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2019)
Article
Virology
Ellen Wu, Yueqi Du, Xiang Gao, Jie Zhang, John Martin, Makedonka Mitreva, Lee Ratner
JOURNAL OF VIROLOGY
(2019)
Article
Multidisciplinary Sciences
Jacob Al-Saleem, Wessel P. Dirksen, Michael P. Martinez, Nikoloz Shkriabai, Mamuka Kvaratskhelia, Lee Ratner, Patrick L. Green
Review
Medical Laboratory Technology
Lee Ratner
SEMINARS IN DIAGNOSTIC PATHOLOGY
(2020)
Article
Virology
Aditi Malu, Tetiana Hutchison, Lacin Yapindi, Katie Smith, Katherine Nelson, Rachel Bergeson, Jordan Pope, Megan Romeo, Carolyn Harrod, Lee Ratner, Carine Van Lint, Robert Harrod
Review
Microbiology
Lee Ratner
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Hematology
Daniel A. Rauch, Kevin C. Conlon, Murali Janakiram, Jonathan E. Brammer, John C. Harding, B. Hilda Ye, Xingxing Zang, Xiaoxin Ren, Sydney Olson, Xiaogang Cheng, Milos D. Miljkovic, Hemalatha Sundaramoorthi, Ancy Joseph, Zachary L. Skidmore, Obi Griffith, Malachi Griffith, Thomas A. Waldmann, Lee Ratner
Article
Virology
Javan K. Kisaka, Lee Ratner, George B. Kyei
JOURNAL OF VIROLOGY
(2020)
Editorial Material
Hematology
Lee Ratner
Article
Virology
Daniel A. Rauch, Sydney L. Olson, John C. Harding, Hemalatha Sundaramoorthi, Youngsoo Kim, Tianyuan Zhou, A. Robert MacLeod, Grant Challen, Lee Ratner
Article
Microbiology
Xiaogang Cheng, Ancy Joseph, Victor Castro, Alice Chen-Liaw, Zachary Skidmore, Jacqueline E. Payton, Lee Ratner, John R. Edwards, Takaharu Ueno, Jun-ichi Fujisawa, Daniel A. Rauch, Grant A. Challen, Michael P. Martinez, Patrick Green, Malachi Griffith
Summary: HTLV-1 is a retrovirus that causes leukemia, lymphoma, and inflammatory disorders. CTCF binding to the virus plays a pivotal role in regulating gene expression, DNA, and histone modifications, affecting virus replication in infected cells.
Article
Microbiology
Yueqi Du, Ellen Wu, Xiang Gao, Jie Zhang, John C. Martin, Bruce A. Rosa, Makedonka Mitreva, Lee Ratner
Summary: This study provides a deeper understanding of the viral genetic determinants of coreceptor shift by combining single-genome sequence analysis and next-generation sequencing. It highlights the importance of low-frequency mutants in the development of drug resistance and the role of specific amino acid substitutions outside the V3 region. Additionally, it emphasizes the significance of residues in the V1/V2, V4, C3, and C4 domains in coreceptor shift.
MICROBIOLOGY SPECTRUM
(2022)
Article
Medicine, Research & Experimental
Jingyu Xiang, Daniel A. Rauch, Devra D. Huey, Amanda R. Panfil, Xiaogang Cheng, Alison K. Esser, Xinming Su, John C. Harding, Yalin Xu, Gregory C. Fox, Francesca Fontana, Takayuki Kobayashi, Junyi Su, Hemalatha Sundaramoorthi, Wing Hing Wong, Yizhen Jia, Thomas J. Rosol, Deborah J. Veis, Patrick L. Green, Stefan Niewiesk, Lee Ratner, Katherine N. Weilbaecher
Article
Biology
Song Cao, Kristine M. Wylie, Matt A. Wyczalkowski, Alla Karpova, Jessica Ley, Sam Sun, R. Jay Mashl, Wen-Wei Liang, Xiaowei Wang, Kimberly Johnson, John F. DiPersio, Hiram Gay, Lee Ratner, Feng Chen, Douglas R. Adkins, Li Ding
COMMUNICATIONS BIOLOGY
(2019)