Article
Biochemistry & Molecular Biology
Meiling Liang, Lihong Dong, Yi Zhen Deng
Summary: Circadian rhythm and ROS homeostasis are important factors in plant-fungus interactions, and understanding the interconnections between the circadian timekeeping machinery and ROS signaling is crucial for disease control strategies.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Plant Sciences
Yi Liu, Danyu Kong, Hui-Lan Wu, Hong-Qing Ling
Summary: This article discusses the important role of iron in plant-pathogen interactions and how plants and pathogens regulate iron levels to maintain fitness. It also proposes directions for future research on this topic.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Review
Microbiology
Johannes Mapuranga, Jiaying Chang, Lirong Zhang, Na Zhang, Wenxiang Yang
Summary: Fungal plant pathogens employ proteinaceous and non-proteinaceous effectors, including secondary metabolites (SMs) and small non-coding RNAs (sRNAs), to manipulate the host plant's defense system. While much research has focused on secreted effector proteins, the roles of fungal SMs and sRNAs have been largely overlooked. Fungal SMs are generated during plant colonization, especially in early infection stages, while fungal sRNAs target plant genes involved in resistance and defense responses. Understanding the functions of these effectors can provide insights into the infection process and host genes targeted. This review discusses the roles of fungal SMs and sRNAs in plant-fungal interactions, translocation of sRNA effectors across kingdoms, and the application of cross-kingdom RNA interference in managing plant diseases.
Article
Chemistry, Multidisciplinary
Ting Song, Geng Yang, Hanxi Zhang, Mengyue Li, Wanyi Zhou, Chuan Zheng, Fengming You, Chunhui Wu, Yiyao Liu, Hong Yang
Summary: This study constructed a GSH-depleting magnetic nanoplatform (D@MOs-P) that enhances ferroptosis by disrupting redox homeostasis and ferritinophagy-mediated iron disorders. The D@MOs-P platform utilizes disulfide bond-mediated glutathione depletion and magnetic hyperthermia to disrupt redox homeostasis and induce ferritinophagy, leading to intense ferroptosis of tumor cells. In vitro and in vivo results demonstrate that D@MOs-P effectively suppresses tumor growth with minimal side effects. This research also highlights the potential of magnetic nanoparticles for T2-weighted MR imaging.
Article
Biochemistry & Molecular Biology
Feng Xiao, Wenxing Xu, Ni Hong, Liping Wang, Yongle Zhang, Guoping Wang
Summary: Botryosphaeria spp. are important phytopathogenic fungi that infect woody plants. This study reveals that BkLiP1 plays a critical role in the virulence and vegetative growth of B. kuwatsukai, and can induce plant cell death as a MAMP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Lin Liu, Yeqiang Xia, Yingchen Li, Yong Zhou, Xiaofeng Su, Xiaojing Yan, Yan Wang, Wende Liu, Hongmei Cheng, Yuanchao Wang, Qing Yang
Summary: Phytopathogenic fungi secrete chitin deacetylase (CDA) to evade the host's immune defense, and the authors identify common structural features of phytopathogenic fungal CDAs and find potential CDA inhibitors for controlling plant diseases.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Tania R. Fernandes, Melani Mariscal, Antonio Serrano, David Segorbe, Teresa Fernandez-Acero, Humberto Martin, David Turra, Antonio Di Pietro
Summary: Mitogen-activated protein kinases (MAPKs) regulate key functions in fungal pathogens, and recent findings suggest that pH plays a role in the modulation of MAPK-mediated pathogenicity. This study reveals that pH controls hyphal chemotropism in the fungal pathogen Fusarium oxysporum and that cytosolic pH fluctuations induce rapid reprogramming of MAPKs. Additionally, the sphingolipid-regulated AGC kinase Ypk1/2 is identified as a key component in pH-modulated MAPK responses.
Article
Multidisciplinary Sciences
Sally H. Mohamed, Man Shun Fu, Sofia Hain, Alanoud Alselami, Eliane Vanhoffelen, Yanjian Li, Ebrima Bojang, Robert Lukande, Elizabeth R. Ballou, Robin C. May, Chen Ding, Greetje Vande Velde, Rebecca A. Drummond
Summary: Microglia do not provide protection against Cryptococcus neoformans brain infection, but may act as a reservoir for early infection and a site for the fungus to access copper micronutrient.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Chi Zhang, Yiran Ren, Huiyu Gu, Lu Gao, Yuanwei Zhang, Ling Lu
Summary: Calcineurin dysfunction disrupts intracellular calcium homeostasis and leads to severe cell death, which can be significantly suppressed by alleviating cytosolic calcium overload or increasing vacuolar calcium storage capacity. This sheds light on how calcineurin regulates intracellular calcium homeostasis for cell survival and could have important implications for antifungal therapy and clinical drug administration.
Review
Plant Sciences
Tatiana Ruiz-Bedoya, Kathryn J. McTavish, Tamar V. Av-Shalom, Darrell Desveaux, David S. Guttman
Summary: The field of plant pathology has provided crucial knowledge and genetic resources for improving plant health by revealing mechanisms underlying the arms race. The study of host-microbe interaction has also uncovered a vast evolutionary history of unexplored plant immunodiversity. This diversity in genetic and ecological factors can be harnessed for the rational engineering of durable resistance in sustainable agriculture.
CURRENT OPINION IN PLANT BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jiayan Shi, Hailong Tian, Liyuan Peng, Canhua Huang, Edouard C. Nice, Bingwen Zou, Haiyuan Zhang
Summary: Colorectal cancer is the second most deadly cancer globally, and chemoresistance is a major obstacle in its treatment. Researchers have designed a nanoplatform that combines chemodynamic therapy and phototherapy, improving the stability and solubility of the drugs. The nanoplatform exhibited excellent antitumor efficacy in colorectal cancer cells and showed potential inhibitory capability in mice xenograft models. This study provides a new paradigm for overcoming chemoresistance and holds great importance in the treatment of colorectal cancer.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Ecology
Ying-Ning Ho, Sin Yong Hoo, Bo-Wei Wang, Chi-Ting Hsieh, Ching-Chih Lin, Chi-Hui Sun, Chia-Chi Peng, Chih Lin, Yu-Liang Yang
Summary: The interactions between bacteria and fungi are complex, with their secreted metabolites playing important roles in microbial communities. Research has shown that a plant pathogen can modify a siderophore produced by bacteria, leading to a loss of antifungal activity.
Review
Plant Sciences
Nathaniel M. Westrick, Damon L. Smith, Mehdi Kabbage
Summary: The article discusses how necrotrophic fungi overcome plant defense compounds to achieve successful pathogenesis, including strategies such as enzymatic detoxification and toxin sequestration and efflux. Efficient detoxification of host PDCs is critical for successful infection and often determines pathogen host range.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Microbiology
Masanori Asai, Yanwen Li, Sandra M. Newton, Brian D. Robertson, Paul R. Langford
Summary: G. mellonella larvae are widely used as surrogate infectious disease models due to their convenience and functional similarity to the innate immune system of vertebrates. Studies on G. mellonella-human intracellular bacteria pathogen infection models have increased understanding of host-bacterial interactive biology and facilitated the testing of antimicrobial drugs. The future use of these models will be driven by advances in G. mellonella genetics, imaging, metabolomics, proteomics, and transcriptomic methodologies.
FEMS MICROBIOLOGY REVIEWS
(2023)
Article
Plant Sciences
Meng-Meng Chen, Si-Ru Yang, Jian Wang, Ya-Li Fang, You-Liang Peng, Jun Fan
Summary: Oxysterol-binding protein-related proteins (ORPs) play important roles in plant-pathogen interactions, triggering oxidative bursts and promoting plant innate immunity; they are also essential for the growth, development, and virulence of fungal pathogens.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Endocrinology & Metabolism
Lily Boutens, Guido J. Hooiveld, Sourabh Dhingra, Robert A. Cramer, Mihai G. Netea, Rinke Stienstra
Editorial Material
Multidisciplinary Sciences
Neta Shlezinger, Henriette Irmer, Sourabh Dhingra, Sarah R. Beattie, Robert A. Cramer, Gerhard H. Braus, Amir Sharon, Tobias M. Hohl
Article
Infectious Diseases
Jayasimha Rao, Dwi Susanti, Johnathon C. Childress, Michael C. Mitkos, Joshua K. Brima, Anthony W. Baffoe-Bonnie, Samuel N. Pearce, Dale Grgurich, Maria Jose Fernandez-Cotarelo, Thomas M. Kerkering, Biswarup Mukhopadhyay
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2018)
Article
Immunology
Alayna K. Caffrey-Carr, Kimberly M. Hilmer, Caitlin H. Kowalski, Kelly M. Shepardson, Rachel M. Temple, Robert A. Cramer, Joshua J. Obar
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Oncology
Matthew P. Alexander, Steven N. Fiering, Gary R. Ostroff, Robert A. Cramer, David W. Mullins
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2018)
Article
Microbiology
Nora Grahl, Emily L. Dolben, Laura M. Filkins, Alex W. Crocker, Sven D. Willger, Hilary G. Morrison, Mitchell L. Sogin, Alix Ashare, Alex H. Gifford, Nicholas J. Jacobs, Joseph D. Schwartzman, Deborah A. Hogan
Article
Microbiology
Leandro Jose de Assis, Adriana Manfiolli, Eliciane Mattos, Joao H. T. Marilhano Fabri, Iran Malavazi, Ilse D. Jacobsen, Matthias Brock, Robert A. Cramer, Arsa Thammahong, Daisuke Hagiwara, Laure Nicolas Annick Ries, Gustavo Henrique Goldman
Article
Microbiology
Matthew E. Mead, Sonja L. Knowles, Huzefa A. Raja, Sarah R. Beattie, Caitlin H. Kowalski, Jacob L. Steenwyk, Lilian P. Silva, Jessica Chiaratto, Laure N. A. Ries, Gustavo H. Goldman, Robert A. Cramer, Nicholas H. Oberlies, Antonis Rokas
Article
Microbiology
Arsa Thammahong, Sourabh Dhingra, Katherine M. Bultman, Joshua D. Kerkaert, Robert A. Cramer
Article
Microbiology
Christiaan A. Rees, Ruina Bao, Michael E. Zegans, Robert A. Cramer
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2019)
Article
Multidisciplinary Sciences
Adrian Kordes, Matthias Preusse, Sven D. Willger, Peter Braubach, Danny Jonigk, Axel Haverich, Gregor Warnecke, Susanne Haeussler
NATURE COMMUNICATIONS
(2019)
Article
Biotechnology & Applied Microbiology
Janne G. Thoeming, Juergen Tomasch, Matthias Preusse, Michal Koska, Nora Grahl, Sarah Pohl, Sven D. Willger, Volkhard Kaever, Mathias Muesken, Susanne Haeussler
NPJ BIOFILMS AND MICROBIOMES
(2020)
Article
Biology
Gang Wang, Jean-Michel Brunel, Matthias Preusse, Negar Mozaheb, Sven D. Willger, Gerald Larrouy-Maumus, Pieter Baatsen, Susanne Haeussler, Jean-Michel Bolla, Francoise Van Bambeke
Summary: The polyaminoisoprenyl compound NV716 re-sensitizes Pseudomonas aeruginosa to antibiotics by permeabilizing the outer membrane and increases the activity of antibiotics on biofilms.
COMMUNICATIONS BIOLOGY
(2022)
Article
Parasitology
M. Kulpraneet, A. Limtrakul, P. Thanomtham, N. Taemaitree, S. Puttikamonkul, S. Pongsunk, S. Srisurapanon, M. Troye-Blomberg, P. Tangteerawatana
TROPICAL BIOMEDICINE
(2019)
Article
Microbiology
Sourabh Dhingra, Jay C. Buckey, Robert A. Cramer
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)