Article
Pharmacology & Pharmacy
Sergio E. Rodriguez, David W. Hawman, Teresa E. Sorvillo, T. Justin O'Neal, Brian H. Bird, Luis L. Rodriguez, Eric Bergeron, Stuart T. Nichol, Joel M. Montgomery, Christina F. Spiropoulou, Jessica R. Spengler
Summary: This article reviews the progress in immunobiology research of Crimean-Congo hemorrhagic fever virus (CCHFV), including the relationship between different outcomes and disease severity, and provides recommendations for future research.
ANTIVIRAL RESEARCH
(2022)
Review
Medicine, General & Internal
Aykut Ozdarendeli
Summary: Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly infectious virus transmitted to humans through tick bites or contact with infected animal blood, causing severe symptoms and a high mortality rate. The lack of effective medical countermeasures and its potential for global spread have made CCHFV a high-priority pathogen. Recent advances in biotechnology and suitable animal models have accelerated the development of CCHFV vaccines.
Article
Public, Environmental & Occupational Health
Ana Catharina Nastri, Amaro Nunes Duarte-Neto, Luciana Vilas Boas Casadio, William Marciel de Souza, Ingra M. Claro, Erika R. Manuli, Gloria Selegatto, Matias C. Saloma, Gabriel Fialkovitz, Mariane Taborda, Bianca Leal de Almeida, Marcello C. Magri, Ana Rubia Guedes, Laura Vieira Perdigao Neto, Fatima Mitie Sataki, Thais Guimaraes, Maria Cassia Mendes-Correa, Tania R. Tozetto-Mendoza, Marcilio Jorge Fumagalli, Yeh-Li Ho, Camila ALves Maia da Silva, Thais M. Coletti, Jacqueline Goes de Jesus, Camila M. Romano, Sarah C. Hill, Oliver Pybus, Joao Renato Rebello Pinho, Felipe Lourenco Ledesma, Yuri R. Casal, Cristina Kanamura, Leonardo Jose Tadeu de Araujo, Camila Santos da Silva Ferreira, Juliana Mariotti Guerra, Luiz Tadeu Moraes Figueiredo, Marisa Dolhnikoff, Nuno R. Faria, Ester C. Sabino, Venacio Avancini, Ferreira Alves, Anna S. Levin
Summary: This study reports two cases of Brazilian Sabi virus infection diagnosed using metagenomics. The patients presented with hepatitis, bleeding, and neurological alterations, leading to death. No nosocomial transmission was found in the contact tracing.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Microbiology
Ayman Ahmed, Yousif Ali, Bashir Salim, Isabelle Dietrich, Jakob Zinsstag
Summary: This study reviewed the epidemiological reports of Crimean-Congo hemorrhagic fever (CCHF) in Sudan between 2010 and 2020. It identified 88 cases of CCHF, including 13 fatalities, with the majority concentrated in the Kordofan region. The study calls for the establishment of a genomic-based integrated One Health surveillance and response system.
Article
Infectious Diseases
Yao Wang, Qing Duan, Bo Pang, Xueying Tian, Jing Ma, Wei Ma, Zengqiang Kou, Hongling Wen
Summary: This study investigated the impact of meteorological factors on HFRS incidence. The results showed that the weekly mean temperature was the most important factor, while relative humidity and pressure had different effects. Both extremely low and high temperatures were significantly associated with HFRS incidence, but with different lag periods and effects.
TRANSBOUNDARY AND EMERGING DISEASES
(2023)
Article
Multidisciplinary Sciences
Amy J. Schuh, Brian R. Amman, Jonathan C. Guito, James C. Graziano, Tara K. Sealy, Shannon G. M. Kirejczyk, Jonathan S. Towner
Summary: This study demonstrates that Egyptian rousette bats (ERBs) are natural vertebrate hosts for Kasokero virus (KASV) and can sustain viremias of appropriate magnitude and duration, supporting virus maintenance through bat-tick-bat transmission cycles. The results also suggest the potential for bat-to-bat transmission and spillover of KASV to humans through contact with infectious oral secretions, feces, or urine.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Yong-Xiang Wu, Xin Yang, Yu Leng, Jia-Chen Li, Lan Yuan, Zhen Wang, Xue-Juan Fan, Chun Yuan, Wei Liu, Hao Li
Summary: This report identifies a family cluster of six patients with SFTS virus (SFTSV) infection. It suggests that the ocular route may be a highly possible mode for SFTSV transmission based on epidemiological, serological, and phylogenetic analysis. Eye protection should be stressed for clinicians when exposed to blood or bloody secretions.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Cell Biology
Dominika Bebnowska, Paulina Niedzwiedzka-Rystwej
Summary: Autophagy, a process essential for maintaining organism homeostasis, plays a complex role in viral infections where it can both aid in fighting the virus and facilitate its replication. Further research is needed to fully understand the mechanisms of autophagy in viral infections and its potential use as a therapeutic target. Studies in specific research models are crucial for this purpose.
Article
Cell Biology
Jun Liu, John C. Trefry, April M. Babka, Christopher W. Schellhase, Kayla M. Coffin, Janice A. Williams, Jo Lynne W. Raymond, Paul R. Facemire, Taylor B. Chance, Neil M. Davis, Jennifer L. Scruggs, Franco D. Rossi, Andrew D. Haddow, Justine M. Zelko, Sandra L. Bixler, Ian Crozier, Patrick L. Iversen, Margaret L. Pitt, Jens H. Kuhn, Gustavo Palacios, Xiankun Zeng
Summary: Persistent Ebola virus infection in the brain ventricular system can occur in macaque survivors after therapeutic treatment, leading to severe tissue damage and inflammation.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Microbiology
Bryce M. Warner
Summary: Viral hemorrhagic fever viruses from various families cause significant morbidity and mortality worldwide annually. Animal models have been essential for understanding pathogenesis and developing therapies and vaccines, but using artificially high virus doses in these models may impact immune responses.
Article
Multidisciplinary Sciences
Aliou Bouba, Kristina Barbara Helle, Kristan Alexander Schneider
Summary: This study uses a predictive model to study the interaction of case isolation, safe funeral practices, and contact tracing. The results suggest that proper diagnosis and isolation have the highest impact on reducing the outbreak, but case isolation and safe funeral practices alone are insufficient. Combining these measures with contact tracing and shortening the time for contact tracing can significantly contain the outbreak.
Review
Public, Environmental & Occupational Health
Thanh Hai Pham, Phuc Nhon Nguyen, Quang Nhat Ho
Summary: Dengue hemorrhagic fever poses a high risk to pregnant women, resulting in increased mortality for both the mother and baby. This case study reports a rare case of dengue transmission during late-stage pregnancy, with both the mother and newborn being infected. Close monitoring of the newborn is crucial to prevent adverse outcomes and infant mortality.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2023)
Article
Environmental Sciences
Jun Deng, Yiwen Zhou, Lin Chu, Yujie Wei, Zhaoxia Li, Tianwei Wang, Cuiting Dai
Summary: The study in the Wangjiaqiao watershed of the Three Gorges Reservoir Area, China, reveals that environmental factors have a greater impact on total nitrogen and total phosphorus concentrations than socioeconomic factors. The concentrations are higher in the wet season compared to the dry season, and the downstream area has higher total nitrogen concentrations than the upstream. The highest total phosphorus concentrations are found in the middle of the watershed.
INTERNATIONAL SOIL AND WATER CONSERVATION RESEARCH
(2023)
Article
Infectious Diseases
Oleg Malinin, Nikolay A. Kiryanov
Summary: This study described the clinical and histopathological features of fatal HFRS in the Udmurt Republic, Russia. The study found that HFRS caused a significant number of deaths in the region.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Environmental Sciences
Chen Yi-Ron, Hou Wen-Shang, Huang Chen-Kang, Chou Chu-Yang
Summary: Reservoirs are artificial ecosystems that affect nearby hydrological and environmental components. Long-term monitoring of fish assemblages in reservoirs is important for understanding fish population fluctuations and developing conservation strategies. A study of the Feitsui Reservoir over 14 years showed that fish assemblages differed between cold and warm seasons, with higher algal counts in the warm season. Before and after 2010, there was partial overlap in fish assemblages, indicating some impact of nonnative fish species on native fish composition.
Article
Multidisciplinary Sciences
Steinar Engen, Huaiyu Tian, Ruifu Yang, Ottar N. Bjornstad, Jason D. Whittington, Nils Chr. Stenseth
Summary: This study provides new insights into epidemic dynamics fueled by external imports using stochastic age-structured Leslie theory, to address the challenges of COVID-19 transmission and migration. By simulating transmission from infected individuals to others, the framework allows for more rapid prediction of epidemic shape and size.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Immunology
Tian Qin, Haijian Zhou, Hongyu Ren, Jiantong Meng, Yinju Du, Mahemut Mahemut, Peng Wang, Nana Luo, Fei Tian, Ming Li, Pu Zhou, Fang Li, Pengyuan Duan, Yinan Li, Na Zhao, Qiwu Yuan, Jinzhong Zhang, Lihong Cheng, Longze Luo, Ming Fang, Xin Huang, Changguo Gu, Huifang Zhou, Min Yang, Shan Lu, Xiangkun Jiang, Hualiang Lin, Huaiyu Tian, Biao Kan, Jianguo Xu
Summary: This study found a higher incidence of hospitalized CAP in China than previously known, with respiratory viruses being more common in infections. Age, seasons, regions, and air pollutants have an impact on pathogen detection.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Yuyang Chen, Naizhe Li, Jose Lourenco, Lin Wang, Bernard Cazelles, Lu Dong, Bingying Li, Yang Liu, Mark jit, Nikos Bosse, Sam Abbott, Raman Velayudhan, Annelies Wilder-Smith, Huaiyu Tian, Oliver J. Bradyt
Summary: COVID-19-related disruption has significantly reduced the incidence of dengue in southeast Asia and Latin America in 2020. Measures such as school closures and reduced time spent in non-residential areas are strongly associated with reduced dengue risk.
LANCET INFECTIOUS DISEASES
(2022)
Article
Immunology
Junrong Liang, Zhen Zhu, Ruiting Lan, Jing Meng, Bram Vrancken, Shan Lu, Dong Jin, Jing Yang, Jianping Wang, Tian Qin, Ji Pu, Li Zhang, Kui Dong, Mingchao Xu, Huaiyu Tian, Taijiao Jiang, Jianguo Xu
Summary: This study sequenced Shigella flexneri isolates from animals and humans in China to determine their relationships and evolutionary history. It found that different lineages of S. flexneri exist in animals and humans, suggesting possible transmission between these two reservoirs. The study also highlighted the importance of animals as hosts for S. flexneri and the need for further research on the public health threat they may pose.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Biochemistry & Molecular Biology
Guogang Zhang, Bingying Li, Jayna Raghwani, Bram Vrancken, Ru Jia, Sarah C. Hill, Guillaume Fournie, Yanchao Cheng, Qiqi Yang, Yuxin Wang, Zengmiao Wang, Lu Dong, Oliver G. Pybus, Huaiyu Tian
Summary: Migratory birds have played a crucial role in the rapid dissemination of highly pathogenic avian influenza (HPAI) H5N8 virus clade 2.3.4.4 across Eurasia. This study investigated the seasonal transmission dynamics of HPAI H5N8 viruses using new genomic data obtained from surveying wild birds in China and tracking the migratory patterns of bird species across China since 2006. The findings reveal the association between the introductions of HPAI H5N8 viruses in different Eurasian regions and the seasonal migration of wild birds, and highlight Europe's role as both a source and a sink in the global HPAI virus transmission network.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Review
Medicine, General & Internal
John S. Brownstein, Benjamin Rader, Christina M. Astley, Huaiyu Tian
Summary: This article discusses the application of AI and machine-learning tools in identifying and tracking disease outbreaks, as well as monitoring mitigation strategies.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Environmental Sciences
Richard Munoz, Carlos Lara, Johny Arteaga, Sebastian I. Vasquez, Gonzalo S. Saldias, Raul P. Flores, Junyu He, Bernardo R. Broitman, Bernard Cazelles
Summary: This study uses time-frequency analyses and wavelet coherence analysis to examine the spatial synchrony between chlorophyll a and turbid river plumes in the inner sea of Chiloe in Chile. The results show that the strength of synchrony varies between the northern and southern areas of the sea, and is likely influenced by large-scale climatic oscillations.
Article
Multidisciplinary Sciences
Lingyue Yang, Zengmiao Wang, Lin Wang, Bram Vrancken, Ruixue Wang, Yuanlong Wei, Benjamin Rader, Chieh- Hsi Wu, Yuyang Chen, Peiyi Wu, Bingying Li, Qiushi Lin, Lu Dong, Yujun Cui, Mang Shi, John S. Brownstein, Nils Chr. Stenseth, Ruifu Yang, Huaiyu Tian
Summary: The emergence of SARS-CoV-2 variants that can evade immune defenses is causing recurrent epidemic waves of COVID-19 globally. This study analyzed the impact of international travel, public health and social measures (PHSM), COVID-19 vaccine rollout, SARS-CoV-2 lineage diversity, and the case growth rate (GR) across 63 countries. The findings highlight the effectiveness of PHSM in mitigating epidemic waves and lineage diversity, even with the rollout of vaccines.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Bernard Cazelles, Kevin Cazelles, Huaiyu Tian, Mario Chavez, Mercedes Pascual
Summary: Identifying climate drivers is crucial for understanding and predicting mosquito-borne infections. This study found that global climate factors have an impact on interannual variability, while local factors affect seasonality, highlighting the importance of considering different time scales when building early-warning systems.
Letter
Infectious Diseases
Oliver J. Brady, Huaiyu Tian
LANCET INFECTIOUS DISEASES
(2022)
Article
Medicine, Research & Experimental
Huaiyu Tian, Naizhe Li, Yapin Li, Moritz U. G. Kraemer, Hua Tan, Yonghong Liu, Yidan Li, Ben Wang, Peiyi Wu, Bernard Cazelles, Jose Lourenco, Dongqi Gao, Dingwei Sun, Wenjing Song, Yuchun Li, Oliver G. Pybus, Guangze Wang, Christopher Dye
Summary: This study examines the effectiveness of malaria control strategies on Hainan Island, China using mathematical modeling and statistical methods. The research finds that insecticide-treated bed nets are the most effective strategy in reducing malaria incidence, with mass drug administration and indoor residual spraying also contributing to malaria control.
COMMUNICATIONS MEDICINE
(2022)
Article
Environmental Sciences
Zengmiao Wang, Yonghong Liu, Yapin Li, Guangze Wang, Jose Lourenco, Moritz Kraemer, Qixin He, Bernard Cazeiles, Yidan Li, Ruixue Wang, Dongqi Gao, Yuchun Li, Wenjing Song, Dingwei Sun, Lu Dong, Oliver G. Pybus, Nils Chr Stenseth, Huaiyu Tian
Summary: This study investigates the spatiotemporal heterogeneity of malaria and the impact of climate change on malaria transmission in Hainan, China. The findings suggest that the timing of the peak incidence of malaria has changed in different regions of Hainan due to rising temperatures. The study provides empirical support for the opposing effects of increasing temperatures on malaria dynamics in lowland and highland regions. The results have important implications for malaria control and should be considered in future modeling and disease burden calculations.
LANCET PLANETARY HEALTH
(2022)
Correction
Medicine, Research & Experimental
Huaiyu Tian, Naizhe Li, Yapin Li, Moritz U. G. Kraemer, Hua Tan, Yonghong Liu, Yidan Li, Ben Wang, Peiyi Wu, Bernard Cazelles, Jose Lourenco, Dongqi Gao, Dingwei Sun, Wenjing Song, Yuchun Li, Oliver G. Pybus, Guangze Wang, Christopher Dye
COMMUNICATIONS MEDICINE
(2022)
