Article
Immunology
Lijun Lu, Lijing Bu, Si-Ming Zhang, Sarah K. Buddenborg, Eric S. Loker
Summary: This study provides a comprehensive overview of the transcriptomics responses of the gastropod Biomphalaria glabrata (Bg) following exposure to the trematode Schistosoma mansoni (Sm). The study identified differences in gene expression between schistosome-susceptible and -resistant Bg strains and revealed distinct response patterns at different time points post-exposure. The findings also highlight shared stress responses and specific gene expression patterns in both resistant and susceptible snails.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Jan Pieter R. Koopman, Emma L. Houlder, Jacqueline J. Janse, Miriam Casacuberta-Partal, Olivia A. C. Lamers, Jeroen C. Sijtsma, Claudia de Dood, Stan T. Hilt, Arifa Ozir-Fazalalikhan, Vincent P. Kuiper, Geert V. T. Roozen, Laura M. de Bes-Roeleveld, Yvonne C. M. Kruize, Linda J. Wammes, Hermelijn H. Smits, Lisette van Lieshout, Govert J. van Dam, Inge M. van Amerongen-Westra, Pauline Meij, Paul L. A. M. Corstjens, Simon P. Jochems, Angela van Diepen, Maria Yazdanbakhsh, Cornelis H. Hokke, Meta Roestenberg
Summary: A single-sex female-only CHI-S model for schistosomiasis was established in this study, providing a tool for vaccine development and understanding early immune responses. The results showed that female-only infections exhibit similar clinical and immunological profiles as male-only infections but are more resistant to treatment with praziquantel.
Article
Parasitology
Abdul Qadeer, Bikash Ranjan Giri, Hanif Ullah, Guofeng Cheng
Summary: Recent studies have shown that Schistosoma can secrete extracellular vesicles (EVs), and identified genes potentially involved in EV biogenesis in Schistosoma japonicum, which are differentially expressed in different developmental stages and sexes of the worms.
Article
Cardiac & Cardiovascular Systems
Robin J. G. Hartman, Katie Owsiany, Lijiang Ma, Simon Koplev, Ke Hao, Lotte Slenders, Mete Civelek, Michal Mokry, Jason C. Kovacic, Gerard Pasterkamp, Gary Owens, Johan L. M. Bjorkegren, Hester M. den Ruijter
Summary: By comparing sex-specific gene regulatory networks (GRNs), clear sex differences in network activity within atherosclerotic tissues were observed. Genes more active in women were associated with mesenchymal cells and endothelial cells, while genes more active in men were associated with the immune system.
Review
Developmental Biology
Ludmila Volozonoka, Anna Miskova, Liene Kornejeva, Inga Kempa, Veronika Bargatina, Linda Gailite
Summary: This study aimed to identify genes associated with female reproductive failure and classify the gene-disease relationships. The results provide comprehensive information on the genetic causes of female infertility, which can contribute to the development of guidelines for genetic testing and reproductive decision-making.
Article
Parasitology
Kristyna Peterkova, Jiri Vorel, Jana Ilgova, Pavel Ostasov, Pavla Fajtova, Lukas Konecny, Marta Chanova, Martin Kasny, Martin Horn, Jan Dvorak
Summary: This study investigates the proteases and inhibitors expressed by Schistosoma mansoni eggs using comparative transcriptomics. The findings suggest that these molecules may play important roles in egg tissue migration, stimulation of angiogenesis, and interaction with host blood and immunity.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sevan N. Alwan, Philip T. LoVerde
Summary: A newly discovered gene fs800 plays a crucial role in egg production of female Schistosoma mansoni, suggesting its inhibition as a potential target to prevent the transmission and pathology of schistosomiasis.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
(2021)
Article
Immunology
Justin R. Kingery, Andrea Chalem, Crispin Mukerebe, Peter S. Shigella, Donald Miyaye, Ruth G. Magawa, Maureen Ward, Samuel E. Kalluvya, Jason McCormick, Jane K. Maganga, Soledad Colombe, Christine Aristide, Paul L. A. M. Corstjens, Myung Hee Lee, John M. Changalucha, Jennifer A. Downs
Summary: This study characterized immune cell populations in cervical brushings of women with and without Schistosoma mansoni infection. The results showed lower frequencies of natural killer T cells and higher frequencies of CD14(+) monocytes in infected women.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Plant Sciences
Sudthana Khlaimongkhon, Sriprapai Chakhonkaen, Keasinee Tongmark, Numphet Sangarwut, Natjaree Panyawut, Thiwawan Wasinanon, Kannika Sikaewtung, Samart Wanchana, Chareerat Mongkolsiriwatana, Julapark Chunwonges, Amorntip Muangprom
Summary: Rice is a crucial food crop for nearly half of the world's population, and its grain yields are affected by temperature changes. Thermosensitive genic male sterility (TGMS) rice is sterile at high temperatures and fertile at low temperatures, making it a good model for studying the effects of temperature on male development. Transcriptomic analysis revealed differential gene expression in TGMS rice panicles under sterile and fertile conditions, with some genes showing unique responses to temperature in TGMS plants compared to wild-type rice. These findings provide insights into the molecular mechanisms controlling TGMS and rice responses to temperature alterations.
Review
Agriculture, Dairy & Animal Science
Luciano Cardoso Santos, Juneo Freitas Silva
Summary: This paper reviews the current knowledge about the modulation and expression profile of hormonal, immunological, redox, and growth mediators involved in the uterine, ovarian, and placental morphophysiology of domestic cats.
Article
Parasitology
Da-Bing Lu, Qiu-Fu Yu, Jie-Ying Zhang, Meng-Tao Sun, Man-Man Gu, Joanne P. Webster, You-Sheng Liang
Summary: Research shows that unpaired female and male schistosomes can survive within their definitive host for at least 1 year and produce viable eggs after subsequent pairing, posing an additional biological challenge in achieving elimination of schistosomiasis.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2021)
Article
Reproductive Biology
Yanyun Zhu, Jing Ye, Ping Qin, Xu Yan, Xinbao Gong, Xiaoqian Li, Ya Liu, Yunsheng Li, Tong Yu, Yunhai Zhang, Yinghui Ling, Juhua Wang, Hongguo Cao, Fugui Fang
Summary: In this study, the changes in serum hormone levels and ovarian gene expression between prepubertal and pubertal goats were analyzed. It was found that hormone levels, including estradiol and cortisol, increased during puberty, while progesterone levels decreased. Analysis of gene expression profiles identified several genes that were significantly differentially expressed during puberty, involving processes such as metabolism, signaling, reproduction, and growth. These findings contribute to a better understanding of the mechanisms underlying goat puberty.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiaolong Wu, Mujun Lu, Damin Yun, Sheng Gao, Shitao Chen, Longfei Hu, Yunhao Wu, Xiaorong Wang, Enkui Duan, C. Yan Cheng, Fei Sun
Summary: The study investigated the dynamic changes in chromatin organization and transcriptomes during human spermatogenesis, identifying different cell types associated with spermatogenesis and high chromatin accessibility in specific chromosomes. Analysis revealed specific transcription factor-binding sites and motifs with high frequency, as well as genes with important roles in spermatogenesis. Unique regions upstream of certain genes were shown to have high accessibility, indicating their significance in supporting human spermatogenesis.
HUMAN MOLECULAR GENETICS
(2022)
Review
Pharmacology & Pharmacy
Rachel E. Young, Dan Dongeun Huh
Summary: Organs-on-a-chip and microphysiological systems have emerged as disruptive in vitro technologies, offering new capabilities to engineer physiological living tissues and organ units. Recent progress in the development of microengineered female reproductive organ models has relevance to drug delivery and discovery, with applications in the study of pregnancy, infertility, and reproductive diseases.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Entomology
Mohsen M. Ramadan, Xingeng Wang
Summary: D. tryoni males remained near the release site after emergence, with the ability to inseminate the highest number of females on the second day after eclosion. Female receptivity decreased after oviposition experience, while multiple mating increased female offspring percentage.
JOURNAL OF ECONOMIC ENTOMOLOGY
(2021)