Article
Multidisciplinary Sciences
Sutopa Talukdar, Vipa Thanachartwet, Varunee Desakorn, Supat Chamnanchanunt, Duangjai Sahassananda, Mukda Vangveeravong, Siripen Kalayanarooj, Anan Wattanathum
Summary: This study identified factors associated with plasma leakage in dengue patients, including body mass index, platelet count, and AST or ALT levels. By assigning a weighted score to each factor, plasma leakage occurrence can be predicted effectively.
Article
Microbiology
Muhammad Amir, Abrar Hussain, Muhammad Asif, Sagheer Ahmed, Hina Alam, Marius Alexandru Moga, Maria Elena Cocuz, Luigi Marceanu, Alexandru Blidaru
Summary: Dengue fever, caused by the Dengue virus (DENV), is a common vector-borne disease belonging to the Flaviviridae family. DENV infects various vertebrates and arthropods, causing diseases in birds, wild animals, and primates. A study on different geographical strains of DENV-3 revealed significant variations in genome size and amino acid sequences.
Article
Multidisciplinary Sciences
Chathurani Sigera, Chaturaka Rodrigo, Nipun L. de Silva, Praveen Weeratunga, Deepika Fernando, Senaka Rajapakse
Summary: This study aimed to characterize the direct costs of managing hospitalized patients with suspected dengue infection in Sri Lanka. The findings suggest that confirming dengue diagnosis using subsidized tests for patients presenting in the first three days of fever may be cost-efficient, as non-dengue patients incur a similar cost per day as dengue patients.
Article
Virology
Priya Verma, Sayan Banerjee, Upasana Baskey, Supradip Dutta, Sagnik Bakshi, Raina Das, Sandip Samanta, Shanta Dutta, Provash C. Sadhukhan
Summary: This study aims to investigate the circulating dengue serotypes and their clinicopathological associations among pediatric patients in Kolkata, India. It was found that all four serotypes co-circulated, with DENV2 being the major strain. The study also observed changes in trends of clinical manifestations and liver function profiles during different phases of dengue fever.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Chemistry, Analytical
Pei-Shan Tsai, Pin-Xian Du, Batuhan Birol Keskin, Nan-Yao Lee, Shu-Wen Wan, Ya-Lan Lin, Wen-Yu Su, Pei-Chun Lin, Wei-Hsun Lin, Hsi-Chang Shih, Tzong-Shiann Ho, Guan-Da Syu
Summary: This study aims to analyze the humoral immunity and cross-reactivity in dengue patients using a multiplexed protein microarray. The results show that patients with severe dengue have higher levels of IgG antibodies against multiple Flavivirus antigens. Logistic regression analysis identifies groups of markers that can effectively distinguish dengue patients from healthy controls and hospitalized patients from mild cases.
ANALYTICAL CHEMISTRY
(2023)
Article
Public, Environmental & Occupational Health
Smonrapat Surasombatpattana, Pornpen Sangthawan, Thanaporn Hortiwakul, Boonsri Charoenmak, Sarunyou Chusri
Summary: This study focused on adult patients with AKI due to DVI in nine network hospitals in Southern Thailand. It found that 17% of patients presented with AKI, with most complications and deterioration occurring within the first week but renal function recovering in the second week. Four AKI patients recovered within 3 months, with significantly higher mortality rates and resource utilization among those with AKI compared to those without AKI. High APACHE II scores and current use of non-steroidal anti-inflammatory agents were significantly associated with the emergence of AKI.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Public, Environmental & Occupational Health
Bui Vu Huy, Dang Thi Thuy
Summary: The incidence of dengue is increasing globally, with clinical manifestations becoming more complex and unpredictable. In addition to shock and severe bleeding, damage to organs such as the neurological, hepatic, and renal systems has been linked to severity and mortality of the disease. Acute kidney injury (AKI) is a common complication in dengue patients that contributes to increased mortality rates.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Medicine, Research & Experimental
Ruixue Hou, Lewis E. Tomalin, Jessica Pintado Silva, Seunghee Kim-Schulze, Stephen S. Whitehead, Ana Fernandez-Sesma, Anna P. Durbin, Mayte Suarez-Farinas
Summary: Understanding the immune response to dengue virus is crucial for dengue vaccine development. This study showed that the tetravalent vaccine has better protective effects against DENV compared to the trivalent admixture. Additionally, differences in immune responses between Black and White participants were observed.
Article
Multidisciplinary Sciences
Mya Myat Ngwe Tun, Aung Kyaw Kyaw, Takeshi Nabeshima, Aung Min Soe, Khine Mya Nwe, Kyaw Ko Ko Htet, Thet Htoo Aung, Thein Thein Htwe, Thidar Aung, Su Su Myaing, Tu Tu Mar, Ei Phyu Lwin, Hlaing Myat Thu, Kyaw Zin Thant, Kouichi Morita
Summary: This study conducted a comprehensive analysis of DENV strains circulating among pediatric patients in Myanmar, highlighting an increasing trend of DENV-3 cases in 2018 with the first detection of genotype 1. Despite this trend, DENV-1 remained the predominant serotype in the study area since 2013.
Article
Public, Environmental & Occupational Health
Fernando Rosso, Luis G. Parra-Lara, Olga L. Agudelo-Rojas, Diana M. Martinez-Ruiz
Summary: This study described the initial symptoms and laboratory test values of patients with dengue or COVID-19 in Cali, Colombia, and found that differences in neutrophil-lymphocyte ratio, platelet count, and absolute neutrophil count within 10 days of symptom onset could help differentiate between the two diseases. These findings may be useful in resource-limited geographical areas.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Virology
Clayton J. Wollner, Michelle Richner, Mariah A. Hassert, Amelia K. Pinto, James D. Brien, Justin M. Richner
Summary: Dengue virus is a common vector-borne viral disease with nearly 400 million infections worldwide annually. Vaccination with a novel mRNA vaccine encoding DENV1 structural proteins induced neutralizing antibody and cellular immune responses, effectively protecting against a lethal DENV challenge. The vaccine provided serotype-specific immunity and reduced antibody-dependent enhancement compared to live viral infection, highlighting its potential as an effective dengue vaccine.
JOURNAL OF VIROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Ikram Waheed, Samreen Khalid, Zubia Jamil
Summary: The study identified clinical parameters (such as bleeding and rash) and laboratory parameters (such as thrombocytopenia and secondary infection) as determinants of complicated dengue infection. A history of previous symptomatic dengue and positive IgG antibodies also increased the risk of severe complicated dengue.
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Laura Teysseyre, Yael Levy, Amelie Renou, Charles Vidal, Mathilde Larghi, Guillaume Biland, Nicolas Ledieu, Nicolas Allou, Julien Jabot, Jerome Allyn
Summary: Dengue disease is rapidly spreading worldwide, with fulminant dengue myocarditis cases more common than previously thought. Treatment of fulminant dengue myocarditis remains challenging, especially in cases of cardiogenic shock.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Environmental Sciences
Duong Q. Phan, Linh D. N. Nguyen, Son T. Pham, Tai Nguyen, Phuong T. T. Pham, Suong T. H. Nguyen, Dien T. Pham, Huong T. Pham, Duy K. Tran, Sa H. Le, Tung T. Pham, Kieu C. D. Nguyen, Gianna Dipalma, Alessio Danilo Inchingolo, Prisco Piscitelli, Alessandro Miani, Scacco Salvatore, Stefania Cantore, Sergey K. Aityan, Andrea Ballini, Francesco Inchingolo, Ciro Gargiulo Isacco, Van H. Pham
Summary: An outbreak of dengue hemorrhagic fever occurred in Quang Nam province, Vietnam in 2018. This study aimed to detect different dengue virus serotypes in patients' blood samples. The results showed that the D4 serotype had the highest detection rate among the 273 patients. Additionally, the study found that RT-rPCR had higher sensitivity than NS1 in the early stage of infection.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Public, Environmental & Occupational Health
Muhammad Bilal Khan, Zih-Syuan Yang, Chih-Yen Lin, Ming-Cheng Hsu, Aspiro Nayim Urbina, Wanchai Assavalapsakul, Wen-Hung Wang, Yen-Hsu Chen, Sheng-Fan Wang
Summary: Dengue is a disease caused by dengue virus infection, and its clinical manifestations vary. Currently, there is a lack of effective antiviral drugs and vaccines, so it is necessary to study the virus characteristics, epidemiology, and develop treatment and control strategies.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Infectious Diseases
Katie A. Parsels, Keri A. Mastro, Jeffrey M. Steele, Stephen J. Thomas, Wesley D. Kufel
Summary: Cefiderocol is a novel siderophore cephalosporin that has shown activity against clinically relevant MDR Gram-negative bacteria. FDA-approved indications include complicated urinary tract infections and hospital-acquired bacterial pneumonia. Clinical trials have demonstrated non-inferiority to standard treatments, but higher all-cause mortality was observed in certain cases.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Microbiology
Adam T. Waickman, Heather Friberg, Gregory D. Gromowski, Wiriya Rutvisuttinunt, Tao Li, Hayden Siegfried, Kaitlin Victor, Michael K. McCracken, Stefan Fernandez, Anon Srikiatkhachorn, Damon Ellison, Richard G. Jarman, Stephen J. Thomas, Alan L. Rothman, Timothy Endy, Jeffrey R. Currier
Summary: The immune response generated by both experimental and natural primary DENV-1 infections are similar, but natural DENV-1 infection has a more pronounced impact on basic cellular processes to induce a multi-layered anti-viral state.
Article
Immunology
Noemia S. Lima, Damee Moon, Samuel Darko, Rafael A. De La Barrera, Leyi Lin, Michael A. Koren, Richard G. Jarman, Kenneth H. Eckels, Stephen J. Thomas, Nelson L. Michael, Kayvon Modjarrad, Daniel C. Douek, Lydie Trautmann
Summary: The study found that prior immunization with JEV has a positive impact on CD4 T cell responses to the ZPIV vaccine, generating more durable responses primarily directed towards conserved epitopes. T cell receptor repertoire analysis revealed preferential expansion of cross-reactive clonotypes between JEV and ZIKV.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Hengsheng Fang, Adam D. Wegman, Kianna Ripich, Heather Friberg, Jeffrey R. Currier, Stephen J. Thomas, Timothy P. Endy, Adam T. Waickman
Summary: Persistent COVID-19 symptoms do not affect the development of dysregulated cellular immune response. Reactivity against SARS-CoV-2 correlates with seasonal human coronaviruses 229E and NL63.
Article
Immunology
Jana Shaw, Samantha Hanley, Telisa Stewart, Daniel A. Salmon, Christine Ortiz, Paula M. Trief, Elizabeth Asiago Reddy, Christopher P. Morley, Stephen J. Thomas, Kathryn B. Anderson
Summary: The majority of healthcare personnel have already received or plan to receive the COVID-19 vaccine. However, there is still hesitancy among some healthcare personnel, particularly in ancillary services. Feasible and effective interventions are needed to address this hesitancy.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Wesley D. Kufel, Keri A. Mastro, Jeffrey M. Steele, Dongliang Wang, Scott W. Riddell, Kristopher M. Paolino, Stephen J. Thomas
Summary: The study evaluated the impact of a pharmacist-facilitated evidence-based bundle initiative with infectious disease consultation on Staphylococcus aureus bacteremia, showing significant improvements in treatment adherence and clinical outcomes after implementation.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2021)
Article
Medicine, General & Internal
Robert W. Frenck, Nicola P. Klein, Nicholas Kitchin, Alejandra Gurtman, Judith Absalon, Stephen Lockhart, John L. Perez, Emmanuel B. Walter, Shelly Senders, Ruth Bailey, Kena A. Swanson, Hua Ma, Xia Xu, Kenneth Koury, Warren V. Kalina, David Cooper, Timothy Jennings, Donald M. Brandon, Stephen J. Thomas, Ozlem Tureci, Dina B. Tresnan, Susan Mather, Philip R. Dormitzer, Ugur Sahin, Kathrin U. Jansen, William C. Gruber
Summary: The BNT162b2 vaccine showed favorable safety profile and a greater immune response in 12-to-15-year-old recipients compared to young adults, and demonstrated high effectiveness against Covid-19.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Immunology
In-Jeong Kim, Paula A. Lanthier, Madeline J. Clark, Rafael A. De la Barrera, Michael P. Tighe, Frank M. Szaba, Kelsey L. Travis, Timothy C. Low-Beer, Tres S. Cookenham, Kathleen G. Lanzer, Derek T. Bernacki, Lawrence L. Johnson, Amanda A. Schneck, Corinna N. Ross, Suzette D. Tardif, Donna Layne-Colon, Stephanie D. Mdaki, Edward J. Dick, Colin Chuba, Olga Gonzalez, Kathleen M. Brasky, John Dutton, Julienne N. Rutherford, Lark L. Coffey, Anil Singapuri, Claudia Sanchez San Martin, Charles Y. Chiu, Stephen J. Thomas, Kayvon Modjarrad, Jean L. Patterson, Marcia A. Blackman
Summary: The Zika purified inactivated virus (ZPIV) vaccine has shown to be effective in reducing fetal malformations and preventing vertical transmission of Zika virus. The vaccine induced virus-neutralizing antibodies that remained above a protective threshold for up to 18 months. These findings demonstrate the potent and durable protective efficacy of ZPIV against Zika virus infection during pregnancy.
Article
Biochemical Research Methods
Krista L. Newell, Mitchell J. Waldran, Stephen J. Thomas, Timothy P. Endy, Adam T. Waickman
Summary: Conventional methods for quantifying and phenotyping antigen-specific lymphocytes require a large number of samples, but our developed BATTLE assay can simultaneously identify SARS-CoV-2 Spike reactive T and B cells, significantly reducing sample requirements and having important implications for immune profiling.
Article
Multidisciplinary Sciences
Angkana T. Huang, Saki Takahashi, Henrik Salje, Lin Wang, Bernardo Garcia-Carreras, Kathryn Anderson, Timothy Endy, Stephen Thomas, Alan L. Rothman, Chonticha Klungthong, Anthony R. Jones, Stefan Fernandez, Sopon Iamsirithaworn, Pawinee Doung-Ngern, Isabel Rodriguez-Barraquer, Derek A. T. Cummings
Summary: The mean age of dengue hemorrhagic fever (DHF) cases in Thailand has increased significantly from 1981 to 2017. This trend can be explained by various factors such as changes in population demographics, reduction in infection hazards, and heterogeneous reporting rates. The demographic transition plays a major role in this change, affecting both the age structure of susceptibility and the number of infectious individuals, leading to a continuing increase in the age of DHF cases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Stephen J. Thomas, John L. Perez, Stephen P. Lockhart, Subramanian Hariharan, Nicholas Kitchin, Ruth Bailey, Katherine Liau, Eleni Lagkadinou, Ozlem Tureci, Ugur Sahin, Xia Xu, Kenneth Koury, Samuel S. Dychter, Claire Lu, Teresa C. Gentile, William C. Gruber
Summary: This study reports the results of the BNT162b2 mRNA COVID-19 vaccine in patients with a history of cancer. The 6-month follow-up showed that the vaccine has a similar safety and efficacy profile in cancer patients compared to the overall trial population. These results are important for the use of the vaccine during the COVID-19 pandemic and future trials in cancer patients.
Article
Microbiology
Angkana T. Huang, Henrik Salje, Ana Coello Escoto, Nayeem Chowdhury, Christian Chavez, Bernardo Garcia-Carreras, Wiriya Rutvisuttinunt, Irina Maljkovic Berry, Gregory D. Gromowski, Lin Wang, Chonticha Klungthong, Butsaya Thaisomboonsuk, Ananda Nisalak, Luke M. Trimmer-Smith, Isabel Rodriguez-Barraquer, Damon W. Ellison, Anthony R. Jones, Stefan Fernandez, Stephen J. Thomas, Derek J. Smith, Richard Jarman, Stephen S. Whitehead, Derek A. T. Cummings, Leah C. Katzelnick
Summary: Neutralizing antibodies play a crucial role in protecting against dengue. However, the factors that contribute to variation in neutralization across different strains of dengue virus are not well understood. This study investigated the effects of changes in the protein sequence of all 10 dengue viral proteins on antigenic distances. The results showed that residue changes in the envelope protein and nonstructural protein 2A had significant effects on antigenic distances, suggesting that nonstructural proteins may modulate neutralizability. This study highlights the importance of considering antigenic determinants beyond the surface proteins in understanding antibody recognition of dengue viruses.
Article
Immunology
Adam T. Waickman, Joseph Lu, Corey Chase, Hengsheng Fang, Erinn McDowell, Erin Bingham, Jeffrey Bogart, Stephen Graziano, Stephen J. Thomas, Teresa Gentile
Summary: Assessment of SARS-CoV-2 mRNA vaccine-elicited immunity in cancer patients undergoing active systemic anti-cancer therapy showed no significant difference in cellular and humoral immune responses compared to those under observation. Despite suboptimal antibody titers in some patients, specific cellular immune responses were still detected, indicating the presence of vaccine-elicited immunity.
Correction
Immunology
In-Jeong Kim, Paula A. Lanthier, Madeline J. Clark, Rafael A. de la Barrera, Michael P. Tighe, Frank M. Szaba, Kelsey L. Travis, Timothy C. Low-Beer, Tres S. Cookenham, Kathleen G. Lanzer, Derek T. Bernacki, Lawrence L. Johnson, Amanda A. Schneck, Corinna N. Ross, Suzette D. Tardif, Donna Layne-Colon, Stephanie D. Mdaki, Edward J. Dick, Colin Chuba, Olga Gonzalez, Kathleen M. Brasky, John Dutton, Julienne N. Rutherford, Lark L. Coffey, Anil Singapuri, Claudia Sanchez San Martin, Charles Y. Chiu, Stephen J. Thomas, Kayvon Modjarrad, Jean L. Patterson, Marcia A. Blackman
Article
Immunology
Irina Maljkovic Berry, Melanie C. Melendrez, Simon Pollett, Katherine Figueroa, Darunee Buddhari, Chonticha Klungthong, Ananda Nisalak, Michael Panciera, Butsaya Thaisomboonsuk, Tao Li, Tyghe G. Vallard, Louis Macareo, In-Kyu Yoon, Stephen J. Thomas, Timothy Endy, Richard G. Jarman
Summary: Researchers used phylogenomic analysis to study household transmissions of dengue virus in Kamphaeng Phet, Thailand, finding that on average, dengue disperses 70 meters per day between households in the community. This approach provides a framework for public health tools to inform control approaches and track dengue transmissions accurately.
EMERGING INFECTIOUS DISEASES
(2021)