Article
Infectious Diseases
Caroline A. Bulstra, David J. Blok, Khorshed Alam, C. Ruth Butlin, Johan Chandra Roy, Bob Bowers, Peter Nicholls, Sake J. de Vlas, Jan Hendrik Richardus
Summary: This study found clear leprosy hotspots in northwest Bangladesh over a 20-year period, with higher transmission activity and more child cases detected in these hotspots. The incidence rates in hotspots were significantly higher than in non-hotspot areas, indicating a higher risk of transmission. The hotspots were not solely a result of active case finding strategies, suggesting underlying epidemiologic mechanisms at play.
INFECTIOUS DISEASES OF POVERTY
(2021)
Article
Urology & Nephrology
Amalia Kermond-Marino, Annie Weng, Selina Kai Xi Zhang, Zac Tran, Mary Huang, Judy Savige
Summary: The study investigated the undiagnosed Fabry disease in the general population and its prevalence. The results showed that the predicted pathogenic GLA variants of Fabry disease occurred in 1 in 3225 individuals in the gnomAD population, with a higher proportion in women. The study confirmed that Fabry disease is more common than previously recognized, especially in women.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Rheumatology
Neus Quilis, Francisca Sivera, Daniel Seoane-Mato, Fernando Perez-Ruiz, Carlos Sanchez-Piedra, Federico Diaz-Gonzalez, Sagrario Bustabad-Reyes
Summary: A study of 4916 individuals estimated the prevalence of gout in Spain to be 2.4%, with a higher prevalence in men compared to women. A substantial proportion of undiagnosed cases were found, emphasizing the need for population-based approaches in estimating disease prevalence.
Article
Hematology
Avi Leader, Noa Dagan, Noam Barda, Idan Goldberg, Pia Raanani, Galia Spectre, Ran Balicer, Anat Gafter-Gvili
Summary: The study found an increased risk of undiagnosed cancer at 12 months after arterial thrombotic events (ATE), especially in patients without documented vascular risk factors or pre-existing cardiovascular disease. The relative risk of cancer was high in all subgroups, with the highest hazard ratio observed in patients without cardiovascular risk factors.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cardiac & Cardiovascular Systems
Goran Bergstrom, Margaretha Persson, Martin Adiels, Elias Bjornson, Carl Bonander, Hakan Ahlstrom, Joakim Alfredsson, Oskar Angeras, Goran Berglund, Anders Blomberg, John Brandberg, Mats Borjesson, Kerstin Cederlund, Ulf de Faire, Olov Duvernoy, Orjan Ekblom, Gunnar Engstrom, Jan E. Engvall, Erika Fagman, Mats Eriksson, David Erlinge, Bjorn Fagerberg, Agneta Flinck, Isabel Goncalves, Emil Hagstrom, Ola Hjelmgren, Lars Lind, Eva Lindberg, Per Lindqvist, Johan Ljungberg, Martin Magnusson, Maria Mannila, Hanna Markstad, Moman A. Mohammad, Fredrik H. Nystrom, Ellen Ostenfeld, Anders Persson, Annika Rosengren, Anette Sandstrom, Anders Sjalander, Magnus C. Skold, Johan Sundstrom, Eva Swahn, Stefan Soderberg, Kjell Toren, Carl Johan Ostgren, Tomas Jernberg
Summary: Through conducting a study using CCTA on a random sample of individuals aged 50 to 64, we found that silent coronary atherosclerosis is common in this population, particularly in individuals with higher CAC scores.
Article
Hematology
Sruthi Cheloor Kovilakam, Muxin Gu, William G. Dunn, Ludovica Marando, Serena Genomics England Res Consortium, Serena Nik-Zainal, Irina Mohorianu, Siddhartha P. Kar, Margarete A. Fabre, Pedro M. Quiros, George S. Vassiliou
Summary: This study investigated the frequency and significance of DDX41 gene variants in UK Biobank participants and identified several novel variants. DDX41 pathogenic variants were found to be significantly associated with MDS and AML, but not with other cancers. DDX41-GPV carriers did not have an increased prevalence of clonal hematopoiesis, and DDX41-mutant MDS/AML showed distinct evolutionary paths. Somatic DDX41 mutations and higher mean red cell volume were associated with increased risk of MDS/AML.
Article
Public, Environmental & Occupational Health
Abdullah Hamadeh, Zeny Feng, Jessmyn Niergarth, William W. L. Wong
Summary: This study estimated the period prevalence of COVID-19 in four Canadian provinces and found a high proportion of undiagnosed infections. Such knowledge can be essential for policymakers in planning control measures and vaccination programs for COVID-19.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2021)
Article
Medicine, General & Internal
Muchi Ditah Chobufo, Atul Singla, Ebad Ur Rahman, Mohammad Osman, Muhammad Zia Khan, Jean Jacques Noubiap, Wilbert S. Aronow, Martin A. Alpert, Sudarshan Balla
Summary: The prevalence of previously undiagnosed angina pectoris (AP) in the absence of established cardiovascular disease (CVD) in the United States is 1.99% in persons aged 40 years and older. Previously undiagnosed AP in individuals without established CVD is an independent predictor of all-cause mortality.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Marie Hauguel-Moreau, Helene Hergault, Laure Cazabat, Marion Pepin, Alain Beauchet, Vincent Aidan, Mounir Ouadahi, Loic Josseran, Mirella Hage, Christophe Rodon, Olivier Dubourg, Ziad Massy, Nicolas Mansencal
Summary: The study aimed to assess the prevalence and long-term change of prediabetes and unknown diabetes in a large middle-aged urban population. The results showed a high prevalence of prediabetes and unknown diabetes, but a decrease over a 12-year period. This highlights the importance of screening and cardiovascular prevention campaigns.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Multidisciplinary Sciences
Karar Zunaid Ahsan, Afrin Iqbal, Kanta Jamil, M. Moinuddin Haider, Shusmita Hossain Khan, Nitai Chakraborty, Peter Kim Streatfield
Summary: This study examined the prevalence, awareness, and management of diabetes among adults in Bangladesh in 2017-18 and its association with socioeconomic status. The results showed significant disparities in diabetes prevalence and awareness based on socioeconomic status, but no significant association between socioeconomic status and diabetes control.
Article
Endocrinology & Metabolism
Han Na Jang, Min Kyong Moon, Bo Kyung Koo
Summary: A nationwide survey in Korea found that about one-third of diabetes patients were unaware of their condition, and 10% of undiagnosed diabetes patients already had developed diabetic retinopathy (DR). There was a significant difference in the prevalence of DR between undiagnosed diabetes patients and known diabetes patients.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Psychology, Clinical
Lyn Ellett, Bjoern Schlier, Jessica L. Kingston, Chen Zhu, Suzanne Ho-Wai So, Tania M. Lincoln, Eric M. J. Morris, Brandon A. Gaudiano
Summary: This study examines the prevalence of pandemic paranoia in the general population across five international sites and its associated sociodemographic profile. The findings show that pandemic paranoia is relatively common and sociodemographic variables play a role in predicting its occurrence.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Rakibul M. Islam, Dianna J. Magliano, Md Nuruzzaman Khan, Mohammad Bellal Hossain, Juwel Rana, John C. Oldroyd
Summary: This study aimed to estimate the prevalence of undiagnosed diabetes among Bangladeshi adults and identify the associated risk factors. The results showed that older age, elevated BMI, highest wealth quintile, hypertension, and being male were risk factors for undiagnosed diabetes. BMI and wealth quintiles were the top two modifiable risk factors contributing to over 50% of undiagnosed diabetes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Rheumatology
Rianne Elise van Bentum, Frank D. Verbraak, Sanne Wolf, Jenny Ongkosuwito, Maarten Boers, H. Stevie Tan, Irene E. van der Horst-Bruinsma
Summary: This observational study evaluated the prevalence of previously unrecognized axial spondyloarthritis (axSpA) in patients with acute anterior uveitis (AAU) referred by ophthalmologists due to concurrent chronic back pain (CBP). The study found a high prevalence of axSpA in these patients, with a significant diagnostic delay in the majority of patients with recurring AAU. Screening for CBP and prompt referral in AAU has a high diagnostic yield and should be promoted among ophthalmologists.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Endocrinology & Metabolism
E. Bonora, M. Dauriz, E. Rinaldi, A. Mantovani, F. Boscari, M. Mazzuccato, M. Vedovato, A. Gallo, E. Toffanin, A. Lapolla, G. P. Fadini, A. Avogaro
Summary: The study found that random capillary blood glucose (RCBG) measurement outperforms the questionnaire in identifying unknown DM and PDM. Using RCBG measurement with a questionnaire as an adjunctive tool can be a simple, fast, and feasible strategy for detecting undiagnosed DM and PDM.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Infectious Diseases
Nimer Ortuno-Gutierrez, Aboubacar Mzembaba, Abdallah Baco, Sofie M. Braet, Assoumani Younoussa, Zahara Salim, Mohamed Amidy, Saverio Grillone, Aouladi Said, Bouke C. de Jong, Jan Hendrik Richardus, Epco Hasker
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Infectious Diseases
Belen Lardizabal Dofitas, Sherjan P. Kalim, Camille B. Toledo, Jan Hendrik Richardus
Summary: This study confirmed that the Philippines is endemic for yaws but at a low level in the schools surveyed. This is an under-estimation due to the limited sampling. The lack of proper disease surveillance after the eradication campaign in the 1960's has made yaws a forgotten disease and has led to its resurgence. Yaws surveillance is needed to determine the extent of yaws in the Philippines and to help develop a strategy to eradicate yaws by 2030.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Review
Infectious Diseases
Yudhy Dharmawan, Ahmad Fuady, Ida J. Korfage, Jan Hendrik Richardus
Summary: This systematic review identified healthcare factors related to delays in case detection in leprosy, including structural factors, health service factors, and intermediate factors. The study found that delays in leprosy case detection were mainly due to misdiagnosis. Improving the training and capacity of healthcare staff and ensuring the sustainability of leprosy control within integrated health services are crucial in reducing detection delays.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Infectious Diseases
Nimer Ortuno-Gutierrez, Pin-Wei Shih, Aashish Wagh, Shivakumar Mugudalabetta, Bijoy Pandey, Bouke C. de Jong, Jan Hendrik Richardus, Epco Hasker
Summary: In India, leprosy shows a clustering pattern at the hamlet level. This study aimed to identify high-incidence hamlets for targeted screening and prophylaxis. Home visits and data collection were conducted, and high-risk clusters were identified. The findings highlight the importance of focusing screening efforts on high-incidence hamlets to increase efficiency.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Infectious Diseases
Dominique L. A. Lescure, Alike W. van der Velden, Natascha Huijser van Reenen, Jan Hendrik Richardus, Helene A. C. M. Voeten
Summary: This study explored the perceptions of antibiotics among immigrants and native Dutch participants through focus group discussions. The findings showed that both immigrants and native Dutch participants had a relatively cautious attitude towards antibiotics, and within-group differences were more significant than between-group differences. Native Dutch participants also faced similar difficulties in communication with their doctors. Immigrants who encountered language barriers experienced even greater communicational challenges.
Article
Public, Environmental & Occupational Health
Belen Dofitas, Maria Christina Batac, Jan Hendrik Richardus
Summary: Yaws cases were confirmed in the Liguasan Marsh, Mindanao Island group, Southern Philippines in 2017, but no cases were confirmed in the Luzon and Visayas Island groups. A surveillance and case detection program was conducted in remote villages and among indigenous peoples in Luzon and Visayas. Among the participants screened, only the Aetas in Quezon province, Luzon, had confirmed yaws cases, including active, latent, and past cases.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2023)
Article
Infectious Diseases
Anneke T. Taal, Akshat Garg, Suchitra Lisam, Ashok Agarwal, Josafa G. Barreto, Wim H. van Brakel, Jan Hendrik Richardus, David J. Blok
Summary: This study proposes a contextualized spatial approach to identify clusters in high-endemic districts more accurately than the standard statistical approach. The contextualized approach includes expert consultation to determine context-specific clusters and is compared to a standard approach. The results show that the contextualized approach can identify clusters more precisely and cover a larger proportion of the population in clusters that need to be targeted for preventive interventions. This approach can be useful for program managers and policy makers in targeting at-risk populations in high-endemic areas while ensuring efficient use of public health resources.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Medicine, General & Internal
Denise E. Twisk, Abraham Meima, Jan Hendrik Richardus, Hannelore M. Gotz
Summary: This study aimed to compare STI-related risk profiles and STI testing rates by geographical area to determine areas for improvement of sexual healthcare access. The study found strong spatial variation in STI testing, STI positivity, and STI risk. Three clusters were identified based on STI risk and testing rate: high-high, high-low, and low, independently of testing rate. Residents in the high-low cluster had comparable STI-related risk and STI positivity but had a significantly lower testing rate compared to the high-high cluster.
Article
Infectious Diseases
Thomas Hambridge, Luc E. Coffeng, Sake J. de Vlas, Jan Hendrik Richardus
Summary: This study aims to evaluate the characteristics of leprosy case detection delay data and select a suitable model to describe the variability of detection delays. The results show that the detection delays are best described by a log-normal distribution, influenced by individual factors such as age, sex, and leprosy subtype.
INFECTIOUS DISEASES OF POVERTY
(2023)
Article
Infectious Diseases
Yudhy Dharmawan, Ida J. Korfage, Ulfah Abqari, Bagoes Widjanarko, Jan Hendrik Richardus
Summary: This study aimed to determine the case detection delay (CDD) of leprosy and its associated factors in Indonesia. The mean CDD was found to be 13.0 months, with patient delay contributing the most. Younger age, male gender, passive case detection, and not having a family member with leprosy were associated with longer CDD. It is recommended that the Indonesian National Leprosy Control Program adopts an integrated intervention program to reduce CDD and prevent disabilities in leprosy patients.
BMC INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
A. T. Taal, J. G. Barreto, G. dos Santos de Sousa, A. Medeiros da Rocha, N. N. Lima Ferreira, J. A. Menezes da Silva, D. C. Hinders, W. H. van Brakel, J. H. Richardus, D. J. Blok
Summary: The geographic distribution of COVID-19, TB, and leprosy varies in Fortaleza, and the associated risk factors are related to wealth. The findings contribute to the development of effective prevention measures.
BMC INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Timo Louis Boelsums, Inge Anna Theresia van de Luitgaarden, Jane Whelan, Hanna Poell, Charlotte Maria Hoffman, Ewout Fanoy, Maaike Buskermolen, Jan Hendrik Richardus
Summary: A study conducted in the Netherlands found that the addition of manual backward contact tracing (BCT) did not provide added value in controlling the COVID-19 pandemic. Out of 7,448 cases surveyed, it was found that some sources were already registered in the electronic database of the public health service, and 13% of potential sources were not yet registered. However, through BCT, only a small number of additional source contacts were traced, and no new COVID-19 cases were identified.
Article
Primary Health Care
Denise E. Twisk, Abraham Meima, Jan Hendrik Richardus, Hannelore M. Goetz
Summary: Insight into sexually transmitted infection (STI) testing and characteristics of those tested in the Netherlands is limited. This study aimed to fill this gap by linking different registers. Results showed that general practitioners (GPs) performed three times more STI tests than sexual health centres (SHC), and STI positivity varied greatly by subgroup and provider. This study highlights the important role of GPs in STI testing.
Article
Dermatology
Yudhy Dharmawan, Ulfah Abqari, Bagoes Widjanarko, Wulandari Santoso, Astri Ferdiana, Jan Hendrik Richardus, Ida J. Korfage
Summary: This study describes the translation and cross-cultural adaptation process of the CDD questionnaire in Indonesia and evaluates its validity and reliability. The findings suggest that the questionnaire is a valid and reliable instrument for determining CDD in Indonesia. Implementation of the questionnaire is recommended for monitoring early case detection and preventing leprosy disability in Indonesia.
Article
Public, Environmental & Occupational Health
Yudhy Dharmawan, Bagoes Widjanarko, Ida J. Korfage, Jan H. Richardus
Summary: The study found a significant delay in case detection and a relationship between disability grade and health-seeking behavior among leprosy patients in Tegal Regency. Nearly half of the patients used self-medication and did not seek appropriate healthcare before being diagnosed with leprosy. These findings suggest that supporting appropriate health-seeking behavior could help reduce the burden of disability caused by leprosy.
SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH
(2022)
