Editorial Material
Pharmacology & Pharmacy
Feiko O. ter Kuile
Summary: Malaria is a major cause of adverse pregnancy outcomes in sub-Saharan Africa and resistance to the recommended antimalarial, sulfadoxine-pyrimethamine, is threatening progress. A trial of dihydroartemisinin-piperaquine as an alternative to sulfadoxine-pyrimethamine showed significant reductions in placental malaria and adverse pregnancy outcomes. The results raise questions about the discrepancies with previous trials.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Infectious Diseases
Oumar Sangho, Moctar Tounkara, Lillian Joyce Whiting-Collins, Madeleine Beebe, Peter J. Winch, Seydou Doumbia
Summary: In the Health District of Selingue, Mali, adherence to IPTp-SP among pregnant women is low, with only 63.7% completing three or more doses. Factors positively influencing completion include early initiation of antenatal care, presence of a community health center in the village, ability to read, knowledge of the utility and recommended dose of the drug.
Article
Public, Environmental & Occupational Health
David Kwame Dosoo, Kezia Malm, Felix Boakye Oppong, Richard Gyasi, Abraham Oduro, John Williams, Dorcas Atibilla, Nana Yaw Peprah, Mieks Twumasi, Seth Owusu-Agyei, Brian Greenwood, Daniel Chandramohan, Kwaku Poku Asante
Summary: The study found no significant difference in the risk of placental malaria, low birth weight, or maternal anemia among women receiving 3 doses compared with those receiving >= 4 doses of IPTp-SP. Receiving >= 3 doses was associated with a lower risk of overall placental malaria infection compared with 2 doses. Monthly administration of IPTp-SP appears to be a practical and safe option for pregnant women to receive multiple doses during pregnancy.
Article
Infectious Diseases
Issa Doumbia, Fomba Seydou, Kone Diakalia, Issam Bennis
Summary: The introduction of a reminder checklist significantly improved pregnant women's adoption of knowledge and practices regarding malaria prevention, with a notable increase in understanding and uptake of IPTp-SP following the checklist intervention. This suggests that generalizing such a checklist reminder could effectively enhance women's knowledge and adherence to preventive measures.
Article
Multidisciplinary Sciences
Iris Lopes-Rafegas, Horace Cox, Toni Mora, Elisa Sicuri
Summary: This study investigates the relationship between risk perception and preventive behavior for selected vector-borne diseases (VBDs), finding that risk perception is significantly influenced by social norms. The study reveals that risk perception significantly increases the likelihood of passive behavior for malaria, but the results for dengue are less clear. The findings highlight the importance of tailoring communication strategies on health risks for VBDs to groups defined by socioeconomic and demographic characteristics.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Ekpereonne B. Esu, Chioma Oringanje, Martin M. Meremikwu
Summary: In sub-Saharan Africa, intermittent preventive treatment (IPT) with antimalarial drugs may reduce the risk of clinical malaria, anemia, and hospital admission in infants, but the efficacy of some drugs appears to decline over time. Studies show positive impacts on treating clinical malaria, anemia, and hospital admissions, while the effect on all-cause mortality remains unclear.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Medicine, General & Internal
Mwayiwawo Madanitsa, Hellen C. Barsosio, Daniel T. R. Minja, George Mtove, Reginald A. Kavishe, James Dodd, Queen Saidi, Eric Onyango, Kephas Otieno, Duolao Wang, Ulla Ashorn, Jenny Hill, Crispin Mukerebe, Samwel Gesase, Omari A. Msemo, Victor Mwapasa, Kamija S. Phiri, Kenneth Maleta, Nigel Klein, Pascal Magnussen, John P. A. Lusingu, Simon Kariuki, Jacklin F. Mosha, Michael Alifrangis, Helle Hansson, Christentze Schmiegelow, Julie R. Gutman, R. Matthew Chico, Feiko O. ter Kuile
Summary: This study evaluates the efficacy of intermittent preventive treatment in pregnancy (IPTp) with dihydroartemisinin-piperaquine compared to sulfadoxine-pyrimethamine in high-resistance areas in East Africa. The results demonstrate that IPTp with dihydroartemisinin-piperaquine and its combination with azithromycin lead to more adverse pregnancy outcomes compared to sulfadoxine-pyrimethamine. This suggests that combining sulfadoxine-pyrimethamine and dihydroartemisinin-piperaquine for IPTp should be considered.
Article
Infectious Diseases
Virtue Fiawokome De-Gaulle, Joseph Kamgno, Verner N. Orish, Agnes Kotoh, Wilfred Mbacham, Harry Tagbor, Pascal Magnussen
Summary: This study investigates the contextual health system factors influencing the delivery of intermittent preventive treatment using sulfadoxine-pyrimethamine (IPTp-SP) and insecticide-treated nets (ITNs) in Ghana. The findings reveal that inadequate training of health staff on malaria delivery directives, confusion among health workers on when to commence IPTp-SP, and stock-outs of SP and ITNs in facilities are major challenges affecting the delivery of these interventions to eligible pregnant women attending antenatal care.
Article
Public, Environmental & Occupational Health
Clara Pons-Duran, Mireia Llach, Charfudin Sacoor, Sergi Sanz, Eusebio Macete, Iwara Arikpo, Maximo Ramirez, Martin Meremikwu, Didier Mbombo Ndombe, Susana Mendez, Manu F. Manun'Ebo, Ranto Ramananjato, Victor R. Rabeza, Maya Tholandi, Elaine Roman, Franco Pagnoni, Raquel Gonzalez, Clara Menendez
Summary: The coverage of IPTp3+ in the surveyed districts in four sub-Saharan countries was generally low, falling short of universal coverage. However, one district in Mozambique showed significantly higher IPTp3+ coverage compared to other areas and the 2018 national average, indicating a need for further investigation into the reasons behind this discrepancy.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Infectious Diseases
Fatima Mahmud Muhammad, Saharnaz Nedjat, Haniye Sadat Sajadi, Mahboubeh Parsaeian, Abraham Assan, Reza Majdzadeh
Summary: The study identified poor policy implementation, low antenatal care attendance, inadequate access to intermittent preventive treatment at community levels, lack of sustainable funding, and poor community engagement as major barriers to IPTp usage among pregnant women in Nigeria.
BMC INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Laia Cirera, Charfudin Sacoor, Martin Meremikwu, Louise Ranaivo, Manu F. Manun'Ebo, Clara Pons-Duran, Dachi Arikpo, Maximo Ramirez, Francesco Ramponi, Antia Figueroa-Romero, Raquel Gonzalez, Christina Maly, Elaine Roman, Elisa Sicuri, Franco Pagnoni, Clara Menendez
Summary: The World Health Organization recommends the use of intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) for the control and prevention of malaria in pregnancy in sub-Saharan Africa. However, the coverage and uptake of IPTp-SP remains low. A pilot project was conducted to assess the cost-effectiveness of community-based delivery of IPTp (C-IPTp) in increasing IPTp uptake. The study found that C-IPTp is a highly cost-effective intervention.
Article
Public, Environmental & Occupational Health
Eugene Kofuor Maafo Darteh, Kwamena Sekyi Dickson, Bright Opoku Ahinkorah, Bernard Afriyie Owusu, Joshua Okyere, Tarif Salihu, Vincent Bio Bediako, Eugene Budu, Wonder Agbemavi, Jane Odurowaah Edjah, Abdul-Aziz Seidu
Summary: The study found that the uptake of IPTp-SP among pregnant women in sub-Saharan African countries is relatively low, with significant inter-country variations. Factors associated with higher odds of optimal IPTp-SP uptake include higher educational level, exposure to media, low parity, and older age group. National policies and interventions to improve coverage and uptake of IPTp-SP should target women with lower education levels, non-exposure to media, higher parity, and younger age group.
ARCHIVES OF PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Yaa Nyarko Agyeman, Sam Newton, Raymond Boadu Annor, Ellis Owusu-Dabo
Summary: A study evaluated the protective effect of Sulphadoxine Pyrimethamine for anaemia among pregnant women in Ghana under the new WHO policy. It found that despite taking 3 or more doses of IPTp-SP, the prevalence of anaemia remained high. Maternal formal education was associated with a reduced burden of anaemia in pregnancy.
Article
Pharmacology & Pharmacy
Eulambius M. Mlugu, Omary Minzi, Appolinary A. R. Kamuhabwa, Eleni Aklillu
Summary: Monthly intermittent preventive treatment with dihydroartemisinin-piperaquine (IPTp-DHP) showed superior protective efficacy against malaria in pregnancy and low birth weight compared to sulfadoxine-pyrimethamine (IPTp-SP).
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Obstetrics & Gynecology
Bola Lukman Solanke, Rasheed Adebayo Yinusa, Olaoye James Oyeleye, Omolayo Bukola Oluwatope, Benjamin Bukky Ilesanmi, Tosin Olajide Oni
Summary: A study in Nigeria explored factors influencing usage of intermittent preventive treatment of malaria in pregnancy (IPTp) and found that the optimal usage rate of IPTp is low.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Public, Environmental & Occupational Health
Matthew Cairns, Yin Bun Cheung, Ying Xu, Kwaku Poku Asante, Seth Owusu-Agyei, Diadier Diallo, Amadou T. Konate, Alassane Dicko, Daniel Chandramohan, Brian Greenwood, Paul Milligan
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2015)
Article
Microbiology
Issaka Zongo, Paul Milligan, Yves Daniel Compaore, A. Fabrice Some, Brian Greenwood, Joel Taming, Philip J. Rosenthal, Cohn Sutherland, Francois Nosten, Jean-Bosco Ouedraogo
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2015)
Article
Immunology
John E. Williams, Matthew Cairns, Fanta Njie, Stephen Laryea Quaye, Timothy Awine, Abraham Oduro, Harry Tagbor, Kalifa Bojang, Pascal Magnussen, Feiko O. ter Kuile, Arouna Woukeu, Paul Milligan, Daniel Chandramohan, Brian Greenwood
CLINICAL INFECTIOUS DISEASES
(2016)
Article
Infectious Diseases
John Williams, Fanta Njie, Matthew Cairns, Kalifa Bojang, Sheick Oumar Coulibaly, Kassoum Kayentao, Ismaela Abubakar, Francis Akor, Khalifa Mohammed, Richard Bationo, Edgar Dabira, Alamissa Soulama, Moussa Djimde, Etienne Guirou, Timothy Awine, Stephen L. Quaye, Jaume Ordi, Ogobara Doumbo, Abraham Hodgson, Abraham Oduro, Pascal Magnussen, Feiko O. ter Kuile, Arouna Woukeu, Paul Milligan, Harry Tagbor, Brian Greenwood, Daniel Chandramohan
Article
Infectious Diseases
Timothy Awine, Mark M. Belko, Abraham R. Oduro, Sunny Oyakhirome, Harry Tagbor, Daniel Chandramohan, Paul Milligan, Matthew Cairns, Brian Greenwood, John E. Williams
Correction
Multidisciplinary Sciences
J. L. NDiaye, B. Cisse, E. H. Ba, J. F. Gomis, C. T. Ndour, J. F. Molez, F. B. Fall, C. Sokhna, B. Faye, E. Kouevijdin, F. K. Niane, M. Cairns, J. F. Trape, C. Rogier, O. Gaye, B. M. Greenwood, P. J. M. Milligan
Article
Multidisciplinary Sciences
J. L. NDiaye, B. Cisse, E. H. Ba, J. F. Gomis, C. T. Ndour, J. F. Molez, F. B. Fall, C. Sokhna, B. Faye, E. Kouevijdin, F. K. Niane, M. Cairns, J. F. Trape, C. Rogier, O. Gaye, B. M. Greenwood, P. J. M. Milligan
Article
Immunology
Sodiomon B. Sirima, Benjamin Mordmueller, Paul Milligan, Ulysse Ateba Ngoa, Fred Kironde, Frank Atuguba, Alfred B. Tiono, Saadou Issifou, Mark Kaddumukasa, Oscar Bangre, Clare Flach, Michael Christiansen, Peter Bang, Roma Chilengi, Soren Jepsen, Peter G. Kremsner, Michael Theisen
Article
Medicine, General & Internal
Badara Cisse, El Hadj Ba, Cheikh Sokhna, Jean Louis NDiaye, Jules F. Gomis, Yankhoba Dial, Catherine Pitt, Mouhamed NDiaye, Matthew Cairns, Ernest Faye, Magatte NDiaye, Aminata Lo, Roger Tine, Sylvain Faye, Babacar Faye, Ousmane Sy, Lansana Konate, Ekoue Kouevijdin, Clare Flach, Ousmane Faye, Jean-Francois Trape, Colin Sutherland, Fatou Ba Fall, Pape M. Thior, Oumar K. Faye, Brian Greenwood, Oumar Gaye, Paul Milligan
Article
Public, Environmental & Occupational Health
Peierdun Mijiti, Li Yuehua, Xue Feng, Paul J. Milligan, Corinne Merle, Wu Gang, Liu Nianqiang, Halmurat Upur
LANCET GLOBAL HEALTH
(2016)
Article
Health Care Sciences & Services
Catherine Pitt, Mouhamed Ndiaye, Lesong Conteh, Ousmane Sy, El Hadj Ba, Badara Cisse, Jules F. Gomis, Oumar Gaye, Jean-Louis Ndiaye, Paul J. Milligan
HEALTH POLICY AND PLANNING
(2017)
Letter
Immunology
Paul Milligan, Clare Flach, Michael Theisen
Article
Multidisciplinary Sciences
Palang Chotsiri, Issaka Zongo, Paul Milligan, Yves Daniel Compaore, Anyirekun Fabrice Some, Daniel Chandramohan, Warunee Hanpithakpong, Francois Nosten, Brian Greenwood, Philip J. Rosenthal, Nicholas J. White, Jean-Bosco Ouedraogo, Joel Tarning
NATURE COMMUNICATIONS
(2019)
Article
Mathematical & Computational Biology
Xiangmei Ma, Paul Milligan, Kwok Fai Lam, Yin Bun Cheung
Summary: Our study investigates five estimators of intervention effects on event rates, each with different precision and power depending on the conditions, and proposes a set of unbiased estimators to control bias in studies with few clusters. The unbiased estimators perform well in simulations and are practically unbiased, while the asymptotically unbiased estimators show good performance with a larger number of clusters. Despite its simplicity, one estimator performs comparably with others in trials with a realistic number of clusters, and two estimators offer higher power in certain conditions.
STATISTICS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Yin Bun Cheung, Xiangmei Ma, K. F. Lam, Chee Fu Yung, Paul Milligan
Summary: Investigated a modeling method for time-varying intervention effects and re-analyzed data from a trial of intermittent preventive treatment for malaria using the Andersen-Gill model.
JOURNAL OF BIOPHARMACEUTICAL STATISTICS
(2023)