Whi2 is a conserved negative regulator of TORC1 in response to low amino acids

The yeast H+-ATPase Pma1 promotes Rag/Gtr-dependent TORC1 activation in response to H+-coupled nutrient uptake

(2018) Elie Saliba et al.   eLife

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

(2017) Rachel L. Wolfson et al.   NATURE

KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signaling

(2017) Rongliang Tong et al.   Oncotarget

Recurrent background mutations in WHI2 impair proteostasis and degradation of misfolded cytosolic proteins in Saccharomyces cerevisiae

(2017) Sophie A. Comyn et al.   Scientific Reports

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

(2016) Lynne Chantranupong et al.   CELL

Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot

(2016) Deborah C.I. Goberdhan et al.   Cell Metabolism

Persistence and drug tolerance in pathogenic yeast

(2016) Rasmus Bojsen et al.   CURRENT GENETICS

TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae

(2016) Seda Yerlikaya et al.   MOLECULAR BIOLOGY OF THE CELL

Colletotrichum orbiculare WHI2, a Yeast Stress-Response Regulator Homolog, Controls the Biotrophic Stage of Hemibiotrophic Infection Through TOR Signaling

(2016) Ken Harata et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy

(2016) Ido Yofe et al.   NATURE METHODS

Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons

(2016) Ivan Gladwyn-Ng et al.   Neural Development

TORC1 Promotes Phosphorylation of Ribosomal Protein S6 via the AGC Kinase Ypk3 in Saccharomyces cerevisiae

(2015) Asier González et al.   PLoS One

MicroRNA-224 promotes tumor progression in nonsmall cell lung cancer

(2015) Ri Cui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

Snf1/AMPK promotes the formation of Kog1/Raptor-bodies to increase the activation threshold of TORC1 in budding yeast

(2015) James E Hughes Hallett et al.   eLife

Rab1A Is an mTORC1 Activator and a Colorectal Oncogene

(2014) Janice D. Thomas et al.   CANCER CELL

Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer

(2014) Jillian Brechbiel et al.   CANCER TREATMENT REVIEWS

State Transitions in the TORC1 Signaling Pathway and Information Processing in Saccharomyces cerevisiae

(2014) J. E. Hughes Hallett et al.   GENETICS

Nitrogen Source Activates TOR (Target of Rapamycin) Complex 1 via Glutamine and Independently of Gtr/Rag Proteins

(2014) Daniele Stracka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytosolic pH Regulates Cell Growth through Distinct GTPases, Arf1 and Gtr1, to Promote Ras/PKA and TORC1 Activity

(2014) Reinhard Dechant et al.   MOLECULAR CELL

The TORC1 effector kinase Npr1 fine tunes the inherent activity of the Mep2 ammonium transport protein

(2014) Mélanie Boeckstaens et al.   Nature Communications

Molecular Specificity, Convergence and Constraint Shape Adaptive Evolution in Nutrient-Poor Environments

(2014) Jungeui Hong et al.   PLoS Genetics

KCTD11Tumor Suppressor Gene Expression Is Reduced in Prostate Adenocarcinoma

(2014) Francesca Zazzeroni et al.   Biomed Research International

Protein partners of KCTD proteins provide insights about their functional roles in cell differentiation and vertebrate development

(2013) Mikhail Skoblov et al.   BIOESSAYS

Methionine Inhibits Autophagy and Promotes Growth by Inducing the SAM-Responsive Methylation of PP2A

(2013) Benjamin M. Sutter et al.   CELL

The Scaffold Protein Atg11 Recruits Fission Machinery to Drive Selective Mitochondria Degradation by Autophagy

(2013) Kai Mao et al.   DEVELOPMENTAL CELL

Use of potassium channel tetramerization domain-containing 12 as a biomarker for diagnosis and prognosis of gastrointestinal stromal tumor

(2013) Tadashi Hasegawa et al.   HUMAN PATHOLOGY

Genome-wide Consequences of Deleting Any Single Gene

(2013) Xinchen Teng et al.   MOLECULAR CELL

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1

(2013) N. Panchaud et al.   Science Signaling

Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis

(2012) Marta Faryna et al.   FASEB JOURNAL

Novel mutations consolidateKCTD7as a progressive myoclonus epilepsy gene

(2012) Maria Kousi et al.   JOURNAL OF MEDICAL GENETICS

A tumour suppressor network relying on the polyamine–hypusine axis

(2012) Claudio Scuoppo et al.   NATURE

Molecular organization of the cullin E3 ligase adaptor KCTD11

(2011) Stefania Correale et al.   BIOCHIMIE

Mitophagy in yeast is independent of mitochondrial fission and requires the stress response gene WHI2

(2011) N. Mendl et al.   JOURNAL OF CELL SCIENCE

insomniac and Cullin-3 Regulate Sleep and Wakefulness in Drosophila

(2011) Nicholas Stavropoulos et al.   NEURON

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

System-Level Analysis of Genes and Functions Affecting Survival During Nutrient Starvation in Saccharomyces cerevisiae

(2010) D. Gresham et al.   GENETICS

Native GABAB receptors are heteromultimers with a family of auxiliary subunits

(2010) Jochen Schwenk et al.   NATURE

Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

(2010) Gianluca Canettieri et al.   NATURE CELL BIOLOGY

Whi2p links nutritional sensing to actin-dependent Ras-cAMP-PKA regulation and apoptosis in yeast

(2009) J. E. Leadsham et al.   JOURNAL OF CELL SCIENCE

KCTD10 interacts with proliferating cell nuclear antigen and its down-regulation could inhibit cell proliferation

(2009) Yibo Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Vam6 GEF Controls TORC1 by Activating the EGO Complex

(2009) Matteo Binda et al.   MOLECULAR CELL

A Genome-Wide Screen for Regulators of TORC1 in Response to Amino Acid Starvation Reveals a Conserved Npr2/3 Complex

(2009) Taavi K. Neklesa et al.   PLoS Genetics

Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects

(2008) W-C Cheng et al.   CELL DEATH AND DIFFERENTIATION

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

High-Quality Binary Protein Interaction Map of the Yeast Interactome Network

(2008) H. Yu et al.   SCIENCE

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE