Article
Biochemistry & Molecular Biology
Sujian Tan, Pin Huan, Baozhong Liu
Summary: A study in mollusk Lottia goshimai revealed that BMP2/4 and Chordin regulate DV patterning, which is a newly reported mechanism in spiralians. The findings suggest that BMP signaling may play a role in modulating the behavior of the blastopore and the organization of the nervous system during DV patterning.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Biochemistry & Molecular Biology
M. Berni, J. Mota, D. Bressan, L. Ribeiro, G. Martins, J. Pereira, I. Ramos, R. Nunes-da-Fonseca, H. Araujo
Summary: Dorsal-ventral (DV) patterning is regulated by the bone morphogenetic pathway (BMP) in Bilateria, with the Toll pathway also playing a role in insect DV patterning. The study of Rhodnius prolixus shows that BMP pathway controls the entire DV axis in this hemiptera species and that the Sog and Tsg proteins have a positive role in establishing a dorsal-to-ventral BMP gradient, which differs from other insect species.
Article
Biology
Matthias Pechmann, Nathan James Kenny, Laura Pott, Peter Heger, Yen-Ta Chen, Thomas Buchta, Orhan Ozuak, Jeremy Lynch, Siegfried Roth
Summary: Dorsoventral pattering in insects relies on Toll and BMP signaling, with variations in the contributions of both pathways across different insect lineages. The cricket Gryllus bimaculatus shows similarity to Drosophila in Toll's direct patterning role, as well as in polarizing BMP signaling. These findings suggest either convergent evolution of Toll's function in Gryllus and Drosophila, or early evolution of a Drosophila-like system that underwent extensive modifications in multiple lineages.
Review
Biology
Zachary A. Grieb, Joseph S. Lonstein
Summary: The interaction between oxytocin and central dopamine and serotonin systems is crucial for behavioral adaptations during the postpartum period. Oxytocin-dopamine interaction regulates maternal motivation and active caregiving behaviors, while oxytocin-serotonin interaction influences other aspects such as nursing, aggression, anxiety-like behavior, and stress coping strategy.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Xiaolin Zhang, Xiuli Shao, Ruijia Zhang, Rongli Zhu, Rui Feng
Summary: We identified differential binding genes on euchromatin in DCM induced by LMNA mutation through ChIP-seq technology and integrated analysis with transcriptome data. Five and 60 candidate genes were identified for downstream analysis, leading to the discovery of 4 key genes (CREBBP, PPP2R2B, BMP4, and BMP7) that may regulate DCM through WNT/beta-catenin or TGF beta-BMP pathways. This study provides insights into the molecular pathogenesis mechanisms of DCM caused by LMNA mutations and highlights potential biomarkers and therapeutic targets.
CLINICAL EPIGENETICS
(2021)
Article
Biology
Eric Van Otterloo, Isaac Milanda, Hamish Pike, Jamie A. Thompson, Hong Li, Kenneth L. Jones, Trevor Williams
Summary: The facial surface ectoderm plays a vital role in the development of cranial neural crest cell populations by providing signals for growth, patterning, and morphogenesis. This study shows that two members of the AP-2 transcription factor family, AP-2 alpha and AP-2ss, are important for normal craniofacial development and signaling. The loss of these transcription factors leads to clefts in the upper face and mandible, as well as fusion of the upper and lower jaws in the hinge region.
Review
Cell Biology
Benjamin L. Martin
Summary: The discovery of mesoderm inducing signals and NMPs has revolutionized the study of vertebrate mesoderm induction and provided new insights into the mechanisms of cell fate determination and morphogenesis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Tianqi Li, Rachel W. S. Chan, Cheuk-Lun Lee, Philip C. N. Chiu, Raymond H. W. Li, Ernest H. Y. Ng, William S. B. Yeung
Summary: Endometrial mesenchymal stem-like cells (eMSC) are regulated by WNT/beta-catenin signaling through the interaction of WNT5A with FZD5 and LRP5, which control the proliferation and self-renewal of eMSC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Alicia Shields, Alla Amcheslavsky, Elizabeth Brown, Tom V. Lee, Yingchao Nie, Takahiro Tanji, Y. Tony Ip, Andreas Bergmann
Summary: The study demonstrates that Drosophila Toll-9 plays a crucial role in compensatory proliferation in undead cells by interacting with Toll-1 to activate the NF-KB pathway. Toll-9's function extends to loser cells during cell competition, indicating a general role in cellular stress responses triggering apoptotic processes.
Article
Neurosciences
Don M. Tucker, Phan Luu
Summary: The cortical connectivity of the primate is well-defined by the Structural Model, with adjacent areas interconnected in a hierarchical network. The computational active inference theory aligns with this architecture, suggesting predictions descend from higher areas and are updated by prediction errors from lower sensory and motor areas. The limbic networks at the top of the hierarchy organize expectancies, with dual limbic divisions reflecting different neural mechanisms for expectancy management, providing top-down and stimulus-bound attentional control.
Article
Multidisciplinary Sciences
Avijit Mallick, Shane K. B. Taylor, Sakshi Mehta, Bhagwati P. Gupta
Summary: The Axin family of proteins plays a crucial role in controlling various cellular processes and providing specificity to signaling pathways. This study focused on the Caenorhabditis elegans Axin homolog pry-1 and its interacting gene picd-1. The findings showed that picd-1 is involved in stress response and lifespan maintenance, and its expression overlaps with pry-1 in multiple tissues. Furthermore, pry-1 and picd-1 inhibit the activity of CRTC-1, a transcriptional coactivator promoting longevity. This study highlights the importance of picd-1 in mediating pry-1 function and suggests a potential role for Cabin-1 domain-containing protein in Axin signaling in other systems.
SCIENTIFIC REPORTS
(2022)
Review
Multidisciplinary Sciences
Kow Essuman, Jeffrey Milbrandt, Jeffery L. Dangl, Marc T. Nishimura
Summary: This article presents the research on the TIR domain in animal, plant, bacterial, and archaeal systems, revealing its diverse functions and enzymatic activities in immune systems. It provides important guidance for future interventions.
Review
Biochemistry & Molecular Biology
Dina Rekler, Chaya Kalcheim
Summary: Research on the development of the dorsal neural tube, particularly the transition between neural crest progenitors and the roof plate, is challenging. Little is known about the mechanisms leading to the end of neural crest production and the transition into a roof plate stage. Further investigation is needed to understand the interactions and signaling properties involved in this developmental process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Claudio D. T. Barros, Maira A. Cardoso, Paulo M. Bisch, Helena M. Araujo, Francisco J. P. Lopes
Summary: The dorsal-ventral patterning of the Drosophila embryo relies on the dynamic balance of Dorsal and Cactus between the cytoplasm and nucleus, with different roles of Dorsal-Cactus trimers in the presence or absence of Toll receptor activation. A predictive model demonstrates the essential role of Cactus in regulating the nuclear translocation of transcription factor Dorsal.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Evolutionary Biology
Pierre Le Pabic, W. James Cooper, Thomas F. Schilling
Article
Developmental Biology
Courtney Alexander, Elizabeth Zuniga, Ira L. Blitz, Naoyuki Wada, Pierre Le Pabic, Yashar Javidan, Tailin Zhang, Ken W. Cho, J. Gage Crump, Thomas F. Schilling
Article
Evolutionary Biology
Pierre Le Pabic, Jean-Luc Scemama, Edmund J. Stellwag
EVOLUTION & DEVELOPMENT
(2010)
Review
Fisheries
T. F. Schilling, P. Le Pabic, T. L. Hoffman
JOURNAL OF APPLIED ICHTHYOLOGY
(2010)
Article
Genetics & Heredity
Pierre Le Pabic, Carrie Ng, Thomas F. Schilling
Article
Evolutionary Biology
Laura A. Hendrick, Grace A. Carter, Erin H. Hilbrands, Brian P. Heubel, Thomas F. Schilling, Pierre Le Pabic
Article
Anatomy & Morphology
Brian P. Heubel, Carson A. Bredesen, Thomas F. Schilling, Pierre Le Pabic
Summary: Background Endochondral ossification is a major bone forming mechanism in vertebrates, defects in which can result in skeletal dysplasia or craniofacial anomalies in humans. The zebrafish holds great potential to advance our understanding of endochondral growth zone development and genetics, yet several important aspects of its biology remain unexplored. Here we provide a comprehensive description of endochondral growth zones in the pharyngeal skeleton, including their developmental progression, cellular activity, and adult fates. Results Postembryonic growth of the pharyngeal skeleton is supported by endochondral growth zones located either at skeletal epiphyses or synchondroses.Col2a1aandcol10a1ain situ hybridization and anti-PCNA immunostaining identify resting-, hypertrophic- and proliferative zones, respectively, in pharyngeal synchondroses. Cellular hypertrophy and matrix deposition contribute little, if at all, to axial growth in most skeletal elements. Zebrafish endochondral growth zones develop during metamorphosis and arrest in adults. Conclusions Two endochondral growth zone configurations in the zebrafish pharyngeal skeleton produce either unidirectional (epiphyses) or bidirectional (synchondroses) growth. Cell proliferation drives endochondral growth and its modulation, in contrast to mammalian long bones in which bone length depends more on cell enlargement during hypertrophy and intramembranous ossification is the default mechanism of bone growth in zebrafish adults.
DEVELOPMENTAL DYNAMICS
(2021)
Article
Anatomy & Morphology
Samantha Reynolds, Christian Pierce, Benjamin Powell, Alexandra Kite, Nicholas Hall-Ruiz, Thomas Schilling, Pierre Le Pabic
Summary: This study describes the developmental expression of Hand1 and Hand2 genes in Copadichromis azureus, showing that the expression of these genes in the gut, peripheral nervous system, and pharyngeal arches may have been fixed in the common ancestor of lobe- and ray-finned fish. Additionally, the distinct expression of these genes in certain embryonic regions suggests lineage-specific divergence in gene expression patterns.
DEVELOPMENTAL DYNAMICS
(2021)
Article
Anatomy & Morphology
Savannah Johnson, Brian Heubel, Carson Bredesen, Thomas Schilling, Pierre Le Pabic
Summary: The shape and size of skeletal elements are determined by embryonic patterning mechanisms and post-embryonic development. Differential endochondral growth drives craniofacial morphological diversity in cichlids. Cellular proliferation and enlargement are the main factors underlying this differential growth.
DEVELOPMENTAL DYNAMICS
(2022)
Editorial Material
Biology
Thomas F. Schilling, Pierre Le Pabic
Summary: A newly discovered enhancer region may have played a key role in the evolution of vertebrates' ability to open and close their jaws.
Article
Developmental Biology
Daniel B. Dranow, Pierre Le Pabic, Thomas F. Schilling
Summary: Non-canonical/beta-catenin-independent Wnt signaling is crucial for tissue/cell polarity in epithelia, but its role in mesenchymal tissues like the skeleton is not well studied. Mutations in non-canonical Wnt signaling pathway genes cause skeletal diseases in humans, disrupting bone growth. Ror2 is a non-canonical Wnt receptor/co-receptor. Zebrafish with ror2-/- mutation show craniofacial skeletal defects and chondrocyte polarity disruptions. The proline-rich domain of Ror2 is required for its function in rescuing the defects.
Article
Anatomy & Morphology
Yuanfa He, Jonathan J. J. Carver, Timothy Erickson, Pierre Le Pabic, Yong Zhu
Summary: This study created a new transgenic zebrafish reporter line Tg(adamts9:EGFP) and used confocal imaging to analyze its expression in various tissues and cells. The results showed strong expression of the adamts9:EGFP transgene in multiple tissues and cells of adult and embryonic zebrafish, suggesting its involvement in the development and physiological functions of various tissues in animals.
DEVELOPMENTAL DYNAMICS
(2023)
Article
Cell Biology
Pierre Le Pabic, Edmund J. Stellwag, Shelby N. Brothers, Jean-Luc Scemama
DEVELOPMENT GENES AND EVOLUTION
(2007)