Article
Biochemistry & Molecular Biology
Yue Liao, Susann Badmann, Till Kaltofen, Doris Mayr, Elisa Schmoeckel, Eileen Deuster, Mareike Mannewitz, Sarah Landgrebe, Thomas Kolben, Anna Hester, Susanne Beyer, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch, Bastian Czogalla
Summary: The study investigated the role of platelet-activating factor acetylhydrolase in BRCA1 mutant ovarian cancer and its interaction with the Wnt signaling pathway. Results suggest that PAF-AH may have a protective role and negatively regulate the Wnt/beta-catenin pathway in ovarian cancer, particularly in BRCA1 mutant cases. Further research is needed to explore the potential use of PAF-AH as a biomarker for predicting disease risk and prognosis in ovarian cancer patients.
Article
Cell Biology
Zhaodong Ji, Wenjuan Tian, Wen Gao, Rongyu Zang, Huaying Wang, Gong Yang
Summary: IL-8 secreted by cancer-associated fibroblasts and cancer cells promotes stemness in human ovarian cancer via the activation of Notch3-mediated signaling, providing a potential novel strategy for ovarian cancer treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Christen A. Khella, Lucyann Franciosa, Lorna Rodirguez-Rodriguez, Resha Rajkarnikar, Karthikeyan Mythreye, Michael L. Gatza
Summary: In this study, the researchers used a proteogenomic approach to analyze HGSOC tumor samples and identified the upregulation of hematopoietic cell kinase (HCK) expression and signaling in poor prognostic HGSOC patients. Further studies showed that HCK promotes cell proliferation, colony formation, and invasive capacity through CD44 and NOTCH3-dependent signaling. This study suggests that targeting the HCK-CD44-NOTCH3 signaling pathway could be a potential therapeutic opportunity for aggressive and recurrent HGSOC patients.
MOLECULAR CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Irina V. Pronina, Leonid A. Uroshlev, Alexey A. Moskovtsev, Danila M. Zaichenko, Elena A. Filippova, Marina V. Fridman, Alexey M. Burdennyy, Vitaly I. Loginov, Tatiana P. Kazubskaya, Nikolay E. Kushlinskii, Alexey A. Dmitriev, Eleonora A. Braga, Olga I. Brovkina
Summary: This study aimed to identify lncRNA-miRNA-mRNA competing triplets that promote ovarian tumorigenesis. Through analysis of tumor samples and experimental validation, multiple RNA triplets related to ovarian cancer were identified. Some triplets showed direct binding sites between lncRNA, mRNA, and miRNA. Transfection of miRNA into cells confirmed novel connections between miRNA and OC-related genes. These findings provide potential biomarkers for early detection of metastasis.
Article
Pharmacology & Pharmacy
Divya Adiga, Samatha Bhat, Sanjiban Chakrabarty, Shama Prasada Kabekkodu
Summary: DOC2B inhibits the Wnt/beta-catenin pathway by enhancing CTNNB1 destruction complex components expression and promoting CTNNB1 degradation. It perturbs CTNNB1 translocation and interaction with transcription factors independently of GSK3beta. The activation of DOC2B-DKK1-senescence-Wnt/beta-catenin-EMT signaling crosstalk may provide a novel approach to restrain malignant behaviors in cervical cancer.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Jun Sun, Dong Yeon Shin, Mark Eiseman, Alisha R. Yallowitz, Na Li, Sarfaraz Lalani, Zan Li, Michelle Cung, Seoyeon Bok, Shawon Debnath, Sofia Jenia Marquez, Tommy E. White, Abdul G. Khan, Ivo C. Lorenz, Jae-Hyuck Shim, Francis S. Lee, Ren Xu, Matthew B. Greenblatt
Summary: Slitrk5 acts as a negative regulator of hedgehog signaling in osteoblasts by enhancing osteoblast differentiation and inhibiting hedgehog signaling downstream targets. Mechanistically, Slitrk5 interacts with hedgehog ligands via its extracellular domain and with PTCH1 via its intracellular domain, ultimately modulating hedgehog signaling activity in the primary cilium.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Meysam Moghbeli, Iman Akhlaghipour, Amir Sadra Zangouei, Zahra Nasrpour Navaei
Summary: Cancer is a major cause of death worldwide, and late diagnosis contributes to treatment failure and high mortality rates in cancer patients. Understanding the molecular mechanisms of tumor progression is crucial for identifying new therapeutic targets and early detection markers. MicroRNAs (miRNAs) play important roles in regulating cellular and molecular mechanisms during tumor progression. Specifically, miR-370 acts as a tumor suppressor by regulating transcription factors and signaling pathways such as WNT, PI3K/AKT, TGF-β, JAK-STAT, and NF-κB. This review highlights the potential of miR-370 as a non-invasive marker for early tumor detection in cancer patients.
PROCESS BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yue Liao, Susann Badmann, Fabian Kraus, Nicole Elisabeth Topalov, Doris Mayr, Thomas Kolben, Anna Hester, Susanne Beyer, Sven Mahner, Udo Jeschke, Fabian Trillsch, Bastian Czogalla, Alexander Burges
Summary: This study investigates the role of platelet-activating factor acetylhydrolase (PLA2G7/PAF-AH) in the Wnt signaling pathway in BRCA1 mutant breast cancer. The results show significantly higher nuclear expression levels of PAF-AH in BRCA1 mutant tissue specimens, which correlates with membranous beta-catenin. PLA2G7 silencing leads to translocation of beta-catenin from the membrane to the nucleus and activation of Wnt signaling downstream genes. These findings suggest a protective effect of high PAF-AH expression in BRCA1 mutant breast cancer through negative regulation of the Wnt pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ozgun Ozalp, Ozge Cark, Yagmur Azbazdar, Betul Haykir, Gokhan Cucun, Ismail Kucukaylak, Gozde Alkan-Yesilyurt, Erdinc Sezgin, Gunes Ozhan
Summary: Nradd, a negative regulator of Wnt/beta-catenin signaling, suppresses Wnt-mediated patterning in zebrafish embryos and mammalian cells, highlighting its role in regulating cell growth and development through modulating Wnt signaling and apoptosis.
Article
Cell Biology
Shu Yang, Jiaqing Xiang, Chuanrui Ma, Guangyan Yang, Xinyu Wang, Hanyong Liu, Guanwei Fan, Lin Kang, Zhen Liang
Summary: This study identifies the role of KLF13 in regulating TGF-(3 signaling and fibrosis. KLF13 recruits a repressor complex to the target genes of TGF-(3, limiting its fibrotic effects. However, persistent activation of TGF-(3 signaling reduces KLF13 levels through degradation and transcriptional inhibition mechanisms, offsetting the anti-fibrotic effect of KLF13.
Article
Oncology
Lu Yang, Shaorong Zhao, Tong Zhu, Jin Zhang
Summary: This study identified GPRC5A as a protective factor against the progression of human triple-negative breast cancer by increasing cell apoptosis via the regulation of the PI3K/Akt signaling pathway. The results suggest that GPRC5A could be a potential therapeutic target for breast cancer treatment.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pathology
Dorothee Schoemaker, Joseph F. Arboleda-Velasquez
Summary: Mutations in the NOTCH3 gene can cause small-vessel disease in humans, including conditions like CADASIL. Different types of NOTCH3 mutations may lead to varying severity of small-vessel disease phenotypes. There is currently a lack of disease-modifying therapies for NOTCH3-associated small-vessel disease, highlighting the need for deeper understanding of underlying molecular mechanisms and defined therapeutic targets.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Shu Yang, Kewei Jiang, Lixing Li, Jiaqing Xiang, Yanchun Li, Lin Kang, Guangyan Yang, Zhen Liang
Summary: This study found that miR-92b-3p can attenuate renal fibrosis by suppressing the TGF-beta signaling pathway and directly targeting TGF-beta receptor 1. Additionally, TGF-beta inhibits the transcription of miR-92b through Snail family transcriptional repressors 1 and 2. MiR-92b-3p may serve as a novel therapeutic approach for mitigating fibrosis in CKD.
Article
Oncology
Yaqi Xue, Ping Wang, Fei Jiang, Jing Yu, Hongmei Ding, Zengli Zhang, Hailong Pei, Bingyan Li
Summary: This study identified the impact of 1α,25(OH)(2)D-3 on ovarian cancer through regulating the expression of lncRNAs, affecting cell signaling pathways and regulation, providing new mechanistic insights into the anticancer effects of this vitamin D analogue.
FRONTIERS IN ONCOLOGY
(2021)
Article
Plant Sciences
Yilong Hu, Limeng Zhou, Yuhua Yang, Wenbin Zhang, Zhonghui Chen, Xiaoming Li, Qian Qian, Fanjiang Kong, Yuge Li, Xu Liu, Xingliang Hou
Summary: The research demonstrates that in Arabidopsis, gibberellin signaling is involved in the regulation of seed storage protein accumulation through the negative regulator RGL3. RGL3 interacts with the critical transcription factor ABI3 to activate the transcription of seed storage protein genes, advancing the understanding of mechanisms in GA-mediated seed storage reserve accumulation.
Article
Oncology
Huei-Jean Huang, Hsiu-Jung Tung, Lan-Yan Yang, Angel Chao, Yun-Hsin Tang, Hung-Hsueh Chou, Wei-Yang Chang, Ren-Chin Wu, Chu-Chun Huang, Chiao-Yun Lin, Min-Jie Liao, Wei-Chun Chen, Cheng-Tao Lin, Min-Yu Chen, Kuan-Gen Huang, Chin-Jung Wang, Ting-Chang Chang, Chyong-Huey Lai
Summary: This observational study investigated the long-term outcomes and HPV genotype changes after conization for high-grade cervical intraepithelial neoplasia (HG-CIN). Results showed that active surveillance may reduce the severity of progression to cancer, and a majority of patients with recurrent CIN2+ had persistent type-specific HPV infections. Effective therapeutic vaccines for such cases are still needed.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Pharmacology & Pharmacy
Pang-Yun Chou, Demei Lee, Chi-Chang Weng, Ren-Chin Wu, Chien-Tun Liao, Shih-Jung Liu
Summary: The study incorporated BMP, an antimicrobial agent, and an analgesic into nanofibrous scaffolds for alveolar cleft therapy. The scaffolds demonstrated extended release of treatment drugs and favorable bone healing in animal tests. Biomolecule- and drug-incorporated nanofibrous scaffolds proved effective in alveolar cleft treatment.
Article
Medicine, General & Internal
Pei-Ching Huang, Ren-Chin Wu, Yu-Hsiang Juan, Hui-Yu Ho, Yung-Chang Lin, Yi-Ting Huang, Shu-Hang Ng, Chyong-Huey Lai, Angel Chao, Gigin Lin
Summary: This study retrospectively investigated the imaging characteristics and diagnostic accuracy of whole-body computed tomography (WBCT) for incidental ovarian tumors in breast cancer patients. The results showed that WBCT can accurately diagnose these ovarian tumors and guide disease management.
Article
Biochemistry & Molecular Biology
Chung-Ying Tsai, Hsiang-Cheng Chi, Ren-Chin Wu, Cheng-Hao Weng, Tzong-Shyuan Tai, Chan-Yu Lin, Tai-Di Chen, Ya-Hui Wang, Li-Fang Chou, Shen-Hsing Hsu, Po-Hung Lin, See-Tong Pang, Hung-Yu Yang
Summary: Compared to Western countries, Taiwan has a significantly higher incidence of urothelial carcinoma (UC). Regulatory T cells (Tregs) have an important role in controlling immune responses within the tumor microenvironment. By analyzing data from 308 UC patients, we found that the expression of CD276 or TIM-3 was positively correlated with late-stage UC and poor prognosis. Patients with high expression of both CD276 and TIM-3 had significantly lower survival rates, indicating that the mRNA levels of these immune checkpoints could serve as independent prognostic biomarkers for UC. We also observed that early-stage UC showed low infiltration of CD8+ cytotoxic T cells and Tregs, while late-stage tumors exhibited high infiltration of cytotoxic T cells with high PD-1 and FOXP3 expression, suggesting the inhibition of cytotoxic T cells in the advanced UC microenvironment. Overall, our findings suggest the potential use of combined immune checkpoint biomarkers for prognosis prediction and the need for early-stage UC treatment to convert "cold" tumors into "hot" tumors for immune checkpoint therapy.
Article
Health Care Sciences & Services
Chiao-Yun Lin, Ren-Chin Wu, Lan-Yan Yang, Shih-Ming Jung, Shir-Hwa Ueng, Yun-Hsin Tang, Huei-Jean Huang, Hsiu-Jung Tung, Cheng-Tao Lin, Hsuan-Yu Chen, Angel Chao, Chyong-Huey Lai
Summary: Diagnostic agreement among pathologists for endometrial hyperplasia is poor. This study identified miR-30a-3p, miR-141, miR-200a, miR-200b, and complete PTEN loss as useful tissue biomarkers for predicting endometrial cancer risk in patients with simple or complex hyperplasia without atypia.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Hsiu-Jung Tung, Ren-Chin Wu, Chiao-Yun Lin, Chyong-Huey Lai
Summary: Endometrial cancer is one of the most common gynecologic cancers worldwide, with increasing incidence rates. The latest molecular classifications have identified different subtypes, but undifferentiated/dedifferentiated EC has not been mentioned. This rare and aggressive type of cancer is resistant to conventional chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Pai-Jui Yeh, Ren-Chin Wu, Chien-Ming Chen, Cheng-Tang Chiu, Ming-Wei Lai, Chien-Chang Chen, Chia-Jung Kuo, Jun-Te Hsu, Ming-Yao Su, Puo-Hsien Le
Summary: This study comprehensively analyzed the risk factors, clinical characteristics, endoscopic features, outcomes, and prognostic factors of CMV esophagitis. Findings showed that male sex, immunocompromised status, and critical illness were risk factors for CMV esophagitis. The major clinical presentations included epigastric pain, fever, dysphagia, and gastrointestinal bleeding. The CMV group had higher mortality rates and longer hospital stays compared to the non-CMV group. Acute kidney injury and intensive care unit admission were predictors of in-hospital mortality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Gastroenterology & Hepatology
Puo-Hsien Le, Yung-Kuan Tsou, Ren-Chin Wu
Summary: Squamous cell papilloma is a disease found in the esophagus.
Article
Multidisciplinary Sciences
Shih-Chiang Huang, Chi-Chung Chen, Jui Lan, Tsan-Yu Hsieh, Huei-Chieh Chuang, Meng-Yao Chien, Tao-Sheng Ou, Kuang-Hua Chen, Ren-Chin Wu, Yu-Jen Liu, Chi-Tung Cheng, Yu-Jen Huang, Liang-Wei Tao, An-Fong Hwu, I-Chieh Lin, Shih-Hao Hung, Chao-Yuan Yeh, Tse-Ching Chen
Summary: The study presents an artificial-intelligence-assisted workflow for lymph node metastasis assessment, which significantly improves the sensitivity of micrometastasis and isolated tumor cells identification in gastric cancer, while reducing review time. Trained on high-resolution images, the algorithm demonstrates high accuracy in identifying metastatic LNs, showing robustness in cross-site evaluation.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Rodney Cheng-En Hsieh, Sunil Krishnan, Ren-Chin Wu, Akash R. Boda, Arthur Liu, Michelle Winkler, Wen-Hao Hsu, Steven Hsesheng Lin, Mien-Chie Hung, Li-Chuan Chan, Krithikaa Rajkumar Bhanu, Anupallavi Srinivasamani, Ricardo Alexandre De Azevedo, Yung-Chih Chou, Ronald A. DePinho, Matthew Gubin, Eduardo Vilar, Chao Hsien Chen, Ravaen Slay, Priyamvada Jayaprakash, Shweta Mahendra Hegde, Genevieve Hartley, Spencer T. Lea, Rishika Prasad, Brittany Morrow, Coline Agnes Couillault, Madeline Steiner, Chun-Chieh Wang, Bhanu Prasad Venkatesulu, Cullen Taniguchi, Yon Son Betty Kim, Junjie Chen, Nils-Petter Rudqvist, Michael A. Curran
Summary: Radiation therapy induces up-regulation of CD47 and PD-L1 through the ATR-mediated DNA repair signaling pathway in CRC cells, which limits TAA cross-presentation and immune activation. Combination therapy with anti-SIRP alpha and anti-PD-1 reverses immune resistance, promotes TAA cross-presentation and robust antitumor immune priming.
SCIENCE IMMUNOLOGY
(2022)
Article
Biology
Geng-Hao Liu, Xin-Cheng Zhuo, Yueh-Hsiang Huang, Hsuan-Miao Liu, Ren-Chin Wu, Chia-Jung Kuo, Ning-Hung Chen, Li-Pang Chuang, Shih-Wei Lin, Yen-Lung Chen, Huang-Yu Yang, Tzung-Yan Lee
Summary: Sleep disturbances and gut health are important factors influencing aging and have significant effects on immunity and metabolism. This study found that sleep fragmentation affects the inflammatory state of the gut, while restorative sleep and acupuncture have positive effects on inflammatory gut remodeling and gut microbial recovery.
Article
Oncology
Angel Chao, Huei-Jean Huang, Chiao-Yun Lin, Chia-Hwa Lee, Chien-Hsing Lin, An-Shine Chao, Chyong-Huey Lai, Ting-Chang Chang, Kai-Yun Wu, Ren-Chin Wu
Summary: This study provides the first comprehensive analysis of the genetic landscape of SCT-NOS and reveals dysregulation in the hypoxia signaling pathway as a key molecular feature of this rare tumor. Long-term follow-up with periodic measurements of androgen levels should be pursued in all cases to detect potential recurrences.
ENDOCRINE-RELATED CANCER
(2023)
Article
Polymer Science
Shuen-Yeo Chen, Fu-Ying Lee, Ren-Chin Wu, Chien-En Chao, Chia-Jung Lu, Shih-Jung Liu
Summary: In this study, hybrid resorbable 3D-printed mesh/electrospun nanofibrous biomolecule-eluting mats were developed for alveolar ridge preservation. The fabrication process involved 3D printing and coaxial electrospinning technologies. The study demonstrated the successful fabrication of resorbable drug-eluting nanofibrous mats for alveolar ridge preservation using 3D printing and coaxial electrospinning technologies.
Article
Gastroenterology & Hepatology
Puo-Hsien Le, Ren-Chin Wu, Chien-Ming Chen, Chia-Jung Kuo, Ming-Yao Su, Cheng-Tang Chiu
Summary: Vedolizumab has a good safety profile for the treatment of inflammatory bowel disease, but it also carries the risk of agranulocytosis, a rare but fatal condition.
ADVANCES IN DIGESTIVE MEDICINE
(2022)
Article
Oncology
Hsiu-Jung Tung, Chi-Yuan Chiang, Wei-Yang Chang, Ren-Chin Wu, Huei-Jean Huang, Lan-Yan Yang, Chiao-Yun Lin, Chun-Chieh Wang, Angel Chao, Chyong-Huey Lai
Summary: This study investigated the management and prognosis of UCS patients. The results showed that salvage therapy using radiotherapy, chemotherapy, or chemoradiotherapy significantly improved survival rates after recurrence (SAR), while disseminated recurrence was associated with worse SAR prognosis.