Article
Biochemistry & Molecular Biology
Aleksandra O. Travina, Nadya Ilicheva, Alexey G. Mittenberg, Sergey Shabelnikov, Anastasia Kotova, Olga Podgornaya
Summary: TRF2's long linker region udTRF2 may play a role in the interaction between TRF2 and lamin proteins, as well as interacting with other proteins. Mass spectrometry analysis revealed that apart from interacting with lamin proteins, udTRF2 also interacts with a variety of other proteins; some of the known interactors are involved in telomere biology, while the roles of others are yet to be investigated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Mathieu Quenu, Artemis D. Treindl, Kate Lee, Daigo Takemoto, Torsten Thuenen, Samad Ashrafi, David Winter, Austen R. D. Ganley, Adrian Leuchtmann, Carolyn A. Young, Murray P. Cox
Summary: Genome rearrangements are common in filamentous fungi, but little is known about their evolution. In this study, we compared 15 complete genomes of the filamentous fungus genus Epichloe and found that the distinction between gene-rich and repeat-rich regions observed in isolated species is widespread across the Epichloe genus. Despite having the same number of nuclear chromosomes, the genomes of Epichloe species show low synteny and substantial rearrangement of gene content. These rearrangements are lineage-dependent and occur over short evolutionary distances with long periods of structural stability.
Review
Cell Biology
Margarida Dantas, Joana T. Lima, Jorge G. Ferreira
Summary: Cells undergo extensive reorganization of the cytoskeleton and nucleus in preparation for mitosis, coordinated by Cyclin-CDK activity. Recent studies suggest that physical forces are also involved in spindle assembly. The crosstalk of physical forces and biochemical signals ensures efficient spindle assembly and chromosome segregation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Erin Bonnell, Emeline Pasquier, Raymund J. Wellinger
Summary: Telomeres, crucial for maintaining genomic stability, pose challenges for replication due to their repetitive nature and the formation of secondary structures, leading to replication fork stalling. Multiple mechanisms are involved in overcoming these obstacles to ensure efficient telomeric DNA duplication and preserve genome integrity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Stefano Giustino Manzo, Lise Dauban, Bas van Steensel
Summary: This article reviews recent advances in the study of LAD-NL interactions, discussing molecular tethers and looseners of LADs, and their link to transcription regulation and genome replication. It also provides a brief summary of technological advances that may uncover new aspects of LAD biology.
CURRENT OPINION IN CELL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Daniela Muoio, Natalie Laspata, Elise Fouquerel
Summary: The ADP-ribose transferase (ART) family consists of 17 enzymes that play important roles in various biological processes, such as DNA repair, replication, and transcription regulation. Five members of this family are crucial for maintaining genome stability and protecting telomere integrity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tom van Schaik, Stefano G. Manzo, Athanasios E. Vouzas, Ning Qing Liu, Hans Teunissen, Elzo de Wit, David M. Gilbert, Bas van Steensel
Summary: Through studying human cell lines, researchers have discovered that Ki-67 is associated with large genomic domains, particularly those involved in late DNA replication. The distribution pattern of Ki-67 on chromosomes varies throughout different stages of the cell cycle. These findings highlight the important roles that Ki-67 plays in genome interactions and heterochromatin organization.
Article
Biotechnology & Applied Microbiology
I. M. Serrano-Leon, P. Prieto, M. Aguilar
Summary: This study provides a comprehensive molecular analysis of telomeres and subtelomeres in barley chromosomes. The findings suggest that these regions play a significant role in the early chromosomal interactions during meiosis in barley, specifically in the homologous recognition and pairing process. Understanding the genome organization of barley and its role in plant breeding is crucial.
Review
Physiology
Jeongjin J. Kim, Alexander Ahn, Jeffrey Ying, Evan Hickman, Andrew T. Ludlow
Summary: Exercise increases the expression and activity of telomerase reverse transcriptase (TERT), promoting telomere maintenance, preventing cellular senescence, and promoting healthy aging by protecting the genome and telomeres.
EXERCISE AND SPORT SCIENCES REVIEWS
(2023)
Editorial Material
Cell Biology
Pawel Kordowitzki
Summary: Research has shown that the pool of oocytes in females starts to decline before birth, and as women age, characteristics such as chromosomal abnormalities, decreased mitochondrial function, and telomere shortening become more common. This may contribute to higher rates of miscarriage and chromosomal non-disjunction in older women who choose to delay pregnancy.
Article
Biotechnology & Applied Microbiology
Lingzhan Xue, Yu Gao, Meiying Wu, Tian Tian, Haiping Fan, Yongji Huang, Zhen Huang, Dapeng Li, Luohao Xu
Summary: The study on the haplotype-resolved genome assembly of zig-zag eel sheds light on the evolution of sex chromosomes and recombination suppression mechanisms, revealing a similar sex-linked region on the X and Y chromosomes and identifying a potential sex-determining gene in the SLR.
Article
Cell Biology
Stefano Squarzoni, Elisa Schena, Patrizia Sabatelli, Elisabetta Mattioli, Cristina Capanni, Vittoria Cenni, Maria Rosaria D'Apice, Davide Andrenacci, Giuseppe Sarli, Valeria Pellegrino, Anna Festa, Fabio Baruffaldi, Gianluca Storci, Massimiliano Bonafe, Catia Barboni, Mara Sanapo, Anna Zaghini, Giovanna Lattanzi
Summary: The study demonstrates that tocilizumab inhibits progeroid features in HGPS cells and progeroid mice, suggesting it as a valuable tool in HGPS therapy and potentially in treating various aging-related disorders.
Review
Oncology
Gustavo Borges, Melanie Criqui, Lea Harrington
Summary: Telomere maintenance is crucial for the integrity of both normal and cancer cells. The instability of telomeres can lead to genome instability in cancer and aging, but cancer cells can partially overcome this instability by increasing telomerase expression.
MOLECULAR ONCOLOGY
(2022)
Article
Cell Biology
Zunpeng Liu, Qianzhao Ji, Jie Ren, Pengze Yan, Zeming Wu, Si Wang, Liang Sun, Zehua Wang, Jiaming Li, Guoqiang Sun, Chuqian Liang, Run Sun, Xiaoyu Jiang, Jianli Hu, Yingjie Ding, Qiaoran Wang, Shijia Bi, Gang Wei, Gang Cao, Guoguang Zhao, Hongmei Wang, Qi Zhou, Juan Carlos Izpisua Belmonte, Jing Qu, Weiqi Zhang, Guang-Hui Liu
Summary: Through large-scale epigenomic analyses of isogenic young, senescent, and progeroid human mesenchymal progenitor cells, the study reveals the association between nuclear deformation and erosion of chromatin organization, and uncovers the role of epigenetic de-repression in exacerbating cellular aging.
DEVELOPMENTAL CELL
(2022)
Article
Biology
Alexander N. Malyavko, Olga A. Petrova, Maria Zvereva, Vladimir Polshakov, Olga A. Dontsova
Summary: This study reports the functional characterization of the Rif1 homologue from the methylotrophic thermotolerant budding yeast Hansenula polymorpha DL-1. The study reveals that Rif1 in H. polymorpha suppresses telomerase-dependent telomere elongation through direct DNA binding and association with the Ku heterodimer. It is also found that Rif1 binds Stn1 and promotes its accumulation at telomeres in H. polymorpha.
Article
Biochemistry & Molecular Biology
Rui Yang, Jenny L. Kerschner, Nehal Gosalia, Daniel Neems, Lidija K. Gorsic, Alexias Safi, Gregory E. Crawford, Steven T. Kosak, Shih-Hsing Leir, Ann Harris
NUCLEIC ACIDS RESEARCH
(2016)
Article
Cell Biology
Ashley M. Wood, Kyle Laster, Ellen L. Rice, Steven T. Kosak
Editorial Material
Biochemistry & Molecular Biology
Danielle Fanslow, Steven T. Kosak
Article
Cell Biology
Leonid A. Serebryannyy, Megan Parilla, Paolo Annibale, Christina M. Cruz, Kyle Laster, Enrico Gratton, Dmitri Kudryashov, Steven T. Kosak, Cara J. Gottardi, Primal de Lanerolle
JOURNAL OF CELL SCIENCE
(2016)
Article
Multidisciplinary Sciences
Daniel S. Neems, Arturo G. Garza-Gongora, Erica D. Smith, Steven T. Kosak
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Oncology
Melissa Schwartz, Olga Camacho-Vanegas, Ashley M. Wood, Matthew Dashkoff, Courtney Whitelock, Timothy T. Harkins, Carmel J. Cohen, Ann Marie Beddoe, Peter Dottino, John A. Martignetti
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2018)
Article
Surgery
Jessica M. Hasak, Carrie L. Roth Bettlach, Katherine B. Santosa, Ellen L. Larson, Jean Stroud, Susan E. Mackinnon
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2018)
Article
Surgery
Katherine B. Santosa, Ellen L. Larson, Bianca Vannucci, Jodi B. Lapidus, Katherine M. Gast, Erika D. Sears, Jennifer F. Waljee, Amy M. Suiter, Cathy C. Sarli, Susan E. Mackinnon, Alison K. Snyder-Warwick
PLASTIC AND RECONSTRUCTIVE SURGERY
(2019)
Article
Multidisciplinary Sciences
Agnieszka I. Laskowski, Daniel S. Neems, Kyle Laster, Chelsee Strojny-Okyere, Ellen L. Rice, Iwona M. Konieczna, Jessica H. Voss, James M. Mathew, Joseph R. Leventhal, Rosalind Ramsey-Goldman, Erica D. Smith, Steven T. Kosak
SCIENTIFIC REPORTS
(2019)
Article
Neurosciences
Deng Pan, Daniel A. Hunter, Lauren Schellhardt, Sally Jo, Katherine B. Santosa, Ellen L. Larson, Anja G. Fuchs, Alison K. Snyder-Warwick, Susan E. Mackinnon, Matthew D. Wood
EXPERIMENTAL NEUROLOGY
(2019)
Article
Clinical Neurology
Ellen L. Larson, Katherine B. Santosa, Susan E. Mackinnon, Alison K. Snyder-Warwick
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2019)