An Evolutionary Perspective on Epistasis and the Missing Heritability

Epistasis as the primary factor in molecular evolution

(2012) Michael S. Breen et al.   NATURE

EpiGPU: exhaustive pairwise epistasis scans parallelized on consumer level graphics cards

(2011) G. Hemani et al.   BIOINFORMATICS

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Natural selection stops the evolution of male attractiveness

(2011) Emma Hine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci

(2011) Jonathan P. Bradfield et al.   PLoS Genetics

BOOST: A Fast Approach to Detecting Gene-Gene Interactions in Genome-wide Case-Control Studies

(2010) Xiang Wan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

TEAM: efficient two-locus epistasis tests in human genome-wide association study

(2010) X. Zhang et al.   BIOINFORMATICS

SHEsisEpi, a GPU-enhanced genome-wide SNP-SNP interaction scanning algorithm, efficiently reveals the risk genetic epistasis in bipolar disorder

(2010) Xiaohan Hu et al.   CELL RESEARCH

EPIBLASTER-fast exhaustive two-locus epistasis detection strategy using graphical processing units

(2010) Tony Kam-Thong et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Phenotypic robustness conferred by apparently redundant transcriptional enhancers

(2010) Nicolás Frankel et al.   NATURE

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

(2010) Amy Strange et al.   NATURE GENETICS

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Missing heritability and strategies for finding the underlying causes of complex disease

(2010) Evan E. Eichler et al.   NATURE REVIEWS GENETICS

On epistasis: why it is unimportant in polygenic directional selection

(2010) J. F. Crow   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Quantitative Genetics of Phenotypic Robustness

(2010) Hunter B. Fraser et al.   PLoS One

Extreme Evolutionary Disparities Seen in Positive Selection across Seven Complex Diseases

(2010) Erik Corona et al.   PLoS One

Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies

(2010) A. Eyre-Walker   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abundant Genetic Variation + Strong Selection = Multivariate Genetic Constraints: A Geometric View of Adaptation

(2009) Bruce Walsh et al.   Annual Review of Ecology Evolution and Systematics

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Human genetic variation and its contribution to complex traits

(2009) Kelly A. Frazer et al.   NATURE REVIEWS GENETICS

Failure to Replicate a Genetic Association May Provide Important Clues About Genetic Architecture

(2009) Casey S. Greene et al.   PLoS One

Robustness: mechanisms and consequences

(2009) Joanna Masel et al.   TRENDS IN GENETICS

Linkage Disequilibrium and Association Mapping

(2008) B.S. Weir   Annual Review of Genomics and Human Genetics

AN EVOLUTIONARY LIMIT TO MALE MATING SUCCESS

(2008) Katrina McGuigan et al.   EVOLUTION

Personal genomes: The case of the missing heritability

(2008) Brendan Maher   NATURE

Heritability in the genomics era — concepts and misconceptions

(2008) Peter M. Visscher et al.   NATURE REVIEWS GENETICS

Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems

(2008) Patrick C. Phillips   NATURE REVIEWS GENETICS

Identification of Small Molecule Inhibitors of Pseudomonas aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen

(2008) Anthony Arnoldo et al.   PLoS Genetics

Data and Theory Point to Mainly Additive Genetic Variance for Complex Traits

(2008) William G. Hill et al.   PLoS Genetics