Causal and Synthetic Associations of Variants in the SERPINA Gene Cluster with Alpha1-antitrypsin Serum Levels

Lipoprotein(a): resurrected by genetics

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Genome-Wide Association Studies IdentifyCHRNA5/3andHTR4in the Development of Airflow Obstruction

(2012) Jemma B. Wilk et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Low-density lipoprotein receptor mutations generate synthetic genome-wide associations

(2012) Daniëlla M Oosterveer et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genome-wide association study of lung function decline in adults with and without asthma

(2012) Medea Imboden et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rare and common variants: twenty arguments

(2012) Greg Gibson   NATURE REVIEWS GENETICS

Three New Alpha1-Antitrypsin Deficiency Variants Help to Define a C-Terminal Region Regulating Conformational Change and Polymerization

(2012) Anna M. Fra et al.   PLoS One

SERPINA1 PiZ and PiS Heterozygotes and Lung Function Decline in the SAPALDIA Cohort

(2012) Gian-Andri Thun et al.   PLoS One

Serum levels and genotype distribution of α1-antitrypsin in the general population

(2012) Ilaria Ferrarotti et al.   THORAX

Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma

(2012) Ke Hao et al.   PLoS Genetics

Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis

(2012) Michael Inouye et al.   PLoS Genetics

Epistatic Selection between Coding and Regulatory Variation in Human Evolution and Disease

(2011) Tuuli Lappalainen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Variable DNA Methylation Is Associated with Chronic Obstructive Pulmonary Disease and Lung Function

(2011) Weiliang Qiu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

(2011) Gosia Trynka et al.   NATURE GENETICS

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

(2011) María Soler Artigas et al.   NATURE GENETICS

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

(2011) Manuel A Rivas et al.   NATURE GENETICS

A Comprehensive Evaluation of Potential Lung Function Associated Genes in the SpiroMeta General Population Sample

(2011) Ma'en Obeidat et al.   PLoS One

Fine Mapping of Five Loci Associated with Low-Density Lipoprotein Cholesterol Detects Variants That Double the Explained Heritability

(2011) Serena Sanna et al.   PLoS Genetics

Genome-wide Association Study IdentifiesBICD1as a Susceptibility Gene for Emphysema

(2010) Xiangyang Kong et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

LocusZoom: regional visualization of genome-wide association scan results

(2010) R. J. Pruim et al.   BIOINFORMATICS

ProbABEL package for genome-wide association analysis of imputed data

(2010) Yurii S Aulchenko et al.   BMC BIOINFORMATICS

α; 1 -Antitrypsin Protease Inhibitor MZ Heterozygosity Is Associated With Airflow Obstruction in Two Large Cohorts

(2010) Inga-Cecilie Sørheim et al.   CHEST

MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes

(2010) Yun Li et al.   GENETIC EPIDEMIOLOGY

Hundreds of variants clustered in genomic loci and biological pathways affect human height

(2010) Hana Lango Allen et al.   NATURE

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation

(2010) Geneviève Galarneau et al.   NATURE GENETICS

Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia

(2010) Christopher T Johansen et al.   NATURE GENETICS

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rare Variants Create Synthetic Genome-Wide Associations

(2010) Samuel P. Dickson et al.   PLOS BIOLOGY

Investigation and Functional Characterization of Rare Genetic Variants in the Adipose Triglyceride Lipase in a Large Healthy Working Population

(2010) Stefan Coassin et al.   PLoS Genetics

Conditional linkage and genome-wide association studies identify UGT1A1 as a major gene for anti-atherogenic serum bilirubin levels—The Framingham Heart Study

(2009) Jing-Ping Lin et al.   ATHEROSCLEROSIS

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap

(2008) A. D. Johnson et al.   BIOINFORMATICS

SERPINA1 Gene Variants in Individuals from the General Population with Reduced  1-Antitrypsin Concentrations

(2008) M. Zorzetto et al.   CLINICAL CHEMISTRY

Investigation of the fine structure of European populations with applications to disease association studies

(2008) Simon C Heath et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genetics of gene expression and its effect on disease

(2008) Valur Emilsson et al.   NATURE

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

(2008) Yurii S Aulchenko et al.   NATURE GENETICS