Testicular Differentiation Occurs in Absence of R-spondin1 and Sox9 in Mouse Sex Reversals

XY Sox9 embryonic loss-of-function mouse mutants show complete sex reversal and produce partially fertile XY oocytes

(2011) Rowena Lavery et al.   DEVELOPMENTAL BIOLOGY

Two distinct origins for Leydig cell progenitors in the fetal testis

(2011) Tony DeFalco et al.   DEVELOPMENTAL BIOLOGY

Hematopoietic prostaglandin D synthase (H-Pgds) is expressed in the early embryonic gonad and participates to the initial nuclear translocation of the SOX9 protein

(2011) Brigitte Moniot et al.   DEVELOPMENTAL DYNAMICS

DMRT1 prevents female reprogramming in the postnatal mammalian testis

(2011) Clinton K. Matson et al.   NATURE

RSPO1/β-Catenin Signaling Pathway Regulates Oogonia Differentiation and Entry into Meiosis in the Mouse Fetal Ovary

(2011) Anne-Amandine Chassot et al.   PLoS One

Loss of R-Spondin1 and Foxl2 Amplifies Female-to-Male Sex Reversal in XX Mice

(2011) A. Auguste et al.   Sexual Development

FGF9 Suppresses Meiosis and Promotes Male Germ Cell Fate in Mice

(2010) Josephine Bowles et al.   DEVELOPMENTAL CELL

Illuminating Testis Morphogenesis in the Mouse

(2010) L. Nel-Themaat et al.   JOURNAL OF ANDROLOGY

Opposing effects of retinoic acid and FGF9 on Nanos2 expression and meiotic entry of mouse germ cells

(2010) Florencia Barrios et al.   JOURNAL OF CELL SCIENCE

Identification of SOX3 as an XX male sex reversal gene in mice and humans

(2010) Edwina Sutton et al.   JOURNAL OF CLINICAL INVESTIGATION

Gonad Morphogenesis in Vertebrates: Divergent Means to a Convergent End

(2009) Tony DeFalco et al.   Annual Review of Cell and Developmental Biology

Somatic Sex Reprogramming of Adult Ovaries to Testes by FOXL2 Ablation

(2009) N. Henriette Uhlenhaut et al.   CELL

FGF signaling directs a center-to-pole expansion of tubulogenesis in mouse testis differentiation

(2009) Ryuji Hiramatsu et al.   DEVELOPMENT

Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal

(2009) S. C. Munger et al.   GENES & DEVELOPMENT

Sox10 gain-of-function causes XX sex reversal in mice: implications for human 22q-linked disorders of sex development

(2009) Juan Carlos Polanco et al.   HUMAN MOLECULAR GENETICS

Cyp26b1 Expression in Murine Sertoli Cells Is Required to Maintain Male Germ Cells in an Undifferentiated State during Embryogenesis

(2009) Hui Li et al.   PLoS One

Ovarian development in mice requires the GATA4-FOG2 transcription complex

(2008) N. L. Manuylov et al.   DEVELOPMENT

Development and morphogenesis of the Wolffian/epididymal duct, more twists and turns

(2008) Avenel Joseph et al.   DEVELOPMENTAL BIOLOGY

Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8

(2008) Francisco Barrionuevo et al.   DEVELOPMENTAL BIOLOGY

R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling

(2008) Kazuma Tomizuka et al.   HUMAN MOLECULAR GENETICS

Stabilization of β-catenin in XY gonads causes male-to-female sex-reversal

(2008) Danielle M. Maatouk et al.   HUMAN MOLECULAR GENETICS

Activation of  -catenin signaling by Rspo1 controls differentiation of the mammalian ovary

(2008) A.-A. Chassot et al.   HUMAN MOLECULAR GENETICS

Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

(2008) Ryohei Sekido et al.   NATURE