A Spontaneous Mutation of the Rat Themis Gene Leads to Impaired Function of Regulatory T Cells Linked to Inflammatory Bowel Disease

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease

(2011) Eleonora A. M. Festen et al.   PLoS Genetics

Contiguous gene deletion of Ptprk and Themis causes T-helper immunodeficiency (thid) in the LEC rat

(2010) Ryohei Iwata et al.   BIOMEDICAL RESEARCH-TOKYO

T Cell Receptor (TCR)-induced Tyrosine Phosphorylation Dynamics Identifies THEMIS as a New TCR Signalosome Component

(2010) Claudia Brockmeyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase Cγ1 is essential for T cell development, activation, and tolerance

(2010) Guoping Fu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Role of the LAT–PLC-γ1 Interaction in T Regulatory Cell Function

(2010) Mariana I. Chuck et al.   JOURNAL OF IMMUNOLOGY

Multiple common variants for celiac disease influencing immune gene expression

(2010) Patrick C A Dubois et al.   NATURE GENETICS

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Regulatory Lymphocytes and Intestinal Inflammation

(2009) Ana Izcue et al.   Annual Review of Immunology

The genetics of autoimmune diseases: a networked perspective

(2009) Sergio E Baranzini   CURRENT OPINION IN IMMUNOLOGY

Prevalence of celiac disease in inflammatory bowel diseases: An IG-IBD multicentre study

(2009) Giovanni Casella et al.   DIGESTIVE AND LIVER DISEASE

Themis, a T cell–specific protein important for late thymocyte development

(2009) Renaud Lesourne et al.   NATURE IMMUNOLOGY

Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection

(2009) Andy L Johnson et al.   NATURE IMMUNOLOGY

Themis controls thymocyte selection through regulation of T cell antigen receptor–mediated signaling

(2009) Guo Fu et al.   NATURE IMMUNOLOGY

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes

(2009) M. S. Patrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory Bowel Disease and Celiac Disease: Overlaps in the Pathology and Genetics, and their Potential Drug Targets

(2009) Eleonora Festen et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

ENU Mutagenesis, a Way Forward to Understand Gene Function

(2008) Abraham Acevedo-Arozena et al.   Annual Review of Genomics and Human Genetics

Autoimmune diseases: insights from genome-wide association studies

(2008) G. Lettre et al.   HUMAN MOLECULAR GENETICS

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS