Article
Neurosciences
Ahmed Radwan, Lisa Decraene, Patrick Dupont, Nicolas Leenaerts, Cristina Simon-Martinez, Katrijn Klingels, Els Ortibus, Hilde Feys, Stefan Sunaert, Jeroen Blommaert, Lisa Mailleux
Summary: This study explored the structural brain connectomes in children with spastic unilateral cerebral palsy (uCP) and its relationship to sensory-motor function using graph theory. The results showed a hyperconnectivity pattern in the CDGM-lesion group compared to the PWM-lesion group, with higher clustering coefficient, characteristic path length, and local efficiency. The CST-wiring pattern was found to be the strongest predictor for motor function. The findings highlight the potential of structural connectomics in understanding disease severity and brain development in children with uCP.
HUMAN BRAIN MAPPING
(2023)
Article
Computer Science, Interdisciplinary Applications
William Consagra, Arun Venkataraman, Zhengwu Zhang
Summary: This paper proposes a statistical method to select q-space directions optimally and estimate the local diffusion function from sparse observations. Simulation studies demonstrate its advantages over existing methods, and it has been validated on real datasets.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yukun Liu, Meng Cui, Xin Gao, Hui Yang, Hewen Chen, Bing Guan, Xiaodong Ma
Summary: This study aimed to predict the postoperative decline in language function and whether it can be recovered based on the preoperative white matter structural network in glioma patients. Machine learning algorithms were used to establish models, and the selected features may reflect the structural basis for the protection and compensation of language function in gliomas.
EUROPEAN RADIOLOGY
(2023)
Article
Pediatrics
Wenxin Zhang, Shang Zhang, Min Zhu, Jian Tang, Xiaoke Zhao, Ying Wang, Yuting Liu, Ling Zhang, Hong Xu
Summary: This study revealed significant alterations in the structural brain network of individuals with bilateral spastic cerebral palsy, indicating disruptions in brain connectivity related to motor and cognitive impairments. The right inferior frontal gyrus, putamen, and thalamus may serve as potential biomarkers for predicting the efficacy of TMS treatment.
FRONTIERS IN PEDIATRICS
(2021)
Article
Neuroimaging
Haoxiang Jiang, Heng Liu, Tingting Huang, Liang Wu, Fan Wu, Congcong Liu, Miaomiao Wang, Chao Jin, Jian Yang, Xianjun Li
Summary: Periventricular white matter injury (PWMI) is a common cause of spastic cerebral palsy (SCP). Diffusion tensor imaging (DTI) can effectively predict SCP in PWMI infants, with the combined node efficiency of specific brain regions showing high sensitivity and specificity in differentiation.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Cell & Tissue Engineering
Man Amanat, Anahita Majmaa, Morteza Zarrabi, Masoumeh Nouri, Masood Ghahvechi Akbari, Ali Reza Moaiedi, Omid Ghaemi, Fatemeh Zamani, Sharif Najafi, Reza Shervin Badv, Massoud Vosough, Amir Ali Hamidieh, Mona Salehi, Hadi Montazerlotfelahi, Ali Reza Tavasoli, Morteza Heidari, Hossein Mohebi, Ali Fatemi, Amir Garakani, Mahmoud Reza Ashrafi
Summary: The study showed that intrathecal injection of umbilical cord tissue mesenchymal stem cells (UCT-MSC) in individuals with cerebral palsy (CP) was safe and led to improvements in gross motor function and quality of life assessments. Diffusion tensor imaging (DTI) also indicated positive changes in white matter integrity, supporting the clinical improvements observed.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Neurosciences
Fan Yang, Samadrita Roy Chowdhury, Heidi I. L. Jacobs, Jorge Sepulcre, Van J. Wedeen, Keith A. Johnson, Joyita Duttaa
Summary: The study suggests that tau neurofibrillary tangles in the brain of AD patients exhibit a stereotypical spatiotemporal trajectory strongly correlated with disease progression, with evidence of tau transmission along preexisting neural connectivity conduits. An analytic graph diffusion framework is proposed for individualized predictive modeling of tau progression in the structural connectome. Using longitudinal imaging data, the model shows high consistency between predicted and observed tau measures, indicating potential as a personalizable predictive framework for AD.
Review
Anatomy & Morphology
Christoph Sperber, Joseph Griffis, Vanessa Kasties
Summary: In vivo tracking of white matter fibres has shed light on the crucial role of brain connectome disruption in neuropsychological deficits. However, using diffusion-weighted magnetic resonance imaging to examine white matter integrity in neurological patients has conceptual limitations and is not widely applicable. Indirect estimation of structural disconnection serves as an elegant and economical alternative.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Psychiatry
Takashi Ohnishi, Wataru Toda, Shuntaro Itagaki, Aya Sato, Junya Matsumoto, Hiroshi Ito, Shiro Ishii, Itaru Miura, Hirooki Yabe
Summary: In this study, the researchers investigated the differences in structural connectivity between drug-naive adult patients with ADHD and healthy controls using diffusion tensor imaging. The results showed that the patients' brain connectivity was disrupted, leading to less efficient information transfer and providing further insight into the pathophysiology of ADHD.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Oncology
Urs Wuertemberger, Martin Diebold, Daniel Erny, Jonas A. Hosp, Oliver Schnell, Peter C. Reinacher, Alexander Rau, Elias Kellner, Marco Reisert, Horst Urbach, Theo Demerath
Summary: Diffusion microstructure imaging (DMI) can be used to differentiate brain metastases from glioblastomas. Perilesional T2 hyperintensity in brain metastases is mainly due to edema, while in glioblastomas, there is tumor infiltration.
Article
Medicine, General & Internal
Lisa von Elling-Tammen, Christina Stark, Kim Ramona Wloka, Evelyn Alberg, Eckhard Schoenau, Ibrahim Duran
Summary: By analyzing the medical devices used by patients with cerebral palsy (CP), we developed a Medical Device Score Calculator (MDSC) to predict the Gross Motor Function Measure-66 (GMFM-66) score. The random forest algorithm proved to be the most accurate for predicting the GMFM-66 score, making the MDSC suitable for scientific research in large patient groups.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Behavioral Sciences
Wei Li, Lei Wang, Zhuomin Lyu, Jiajie Chen, Yongbin Li, Yichen Sun, Jia Zhu, Wei Wang, Yarong Wang, Qiang Li
Summary: This study explores the differences in psychological symptoms and brain structural connections between individuals with methamphetamine use disorder (MAUD) and heroin use disorder (HUD). By using diffusion tensor imaging and probabilistic tractography, the researchers found that individuals in the MAUD group exhibited higher scores in anxiety, hostility, and symptoms of schizophrenia. The HUD group showed higher global efficiency and network strength compared to the MAUD and healthy control groups. The findings suggest that the topological structural connections differ between HUD and MAUD, providing insights into the neurobiological mechanisms underlying the psychological differences between these two substance use disorders.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Endocrinology & Metabolism
Anna Dewenter, Benno Gesierich, Annemieke Ter Telgte, Kim Wiegertjes, Mengfei Cai, Mina A. Jacob, Jose P. Marques, David G. Norris, Nicolai Franzmeier, Frank-Erik De Leeuw, Anil M. Tuladhar, Marco Duering
Summary: This study evaluated the clinical and technical validity of structural brain network analysis in patients with cerebral small vessel disease. The findings suggest that brain networks offer only minimal additional benefit compared to simpler global white matter diffusion metrics and do not effectively capture short-term disease progression.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Clinical Neurology
Juho Dahl, Olli Tenovuo, Jussi P. Posti, Jussi Hirvonen, Ari J. Katila, Janek Frantzen, Henna-Riikka Maanpaa, Riikka Takala, Eliisa Loyttyniemi, Jussi Tallus, Virginia Newcombe, David K. Menon, Peter J. Hutchinson, Mehrbod Mohammadian
Summary: Cerebral microbleeds are associated with the clinical severity of traumatic brain injury but have a weaker association with white matter integrity.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Jennifer L. Whitwell, Nirubol Tosakulwong, Heather M. Clark, Farwa Ali, Hugo Botha, Stephen D. Weigand, Irene Sintini, Mary M. Machulda, Christopher G. Schwarz, Robert I. Reid, Clifford R. Jack, J. Eric Ahlskog, Keith A. Josephs
Summary: This study used diffusion tensor imaging to examine patterns of white matter tract degeneration in PSP-RS, PSP-SL, and PSP-P. The body of the corpus callosum showed some utility in differentiating PSP-SL from the other two variants.
JOURNAL OF NEUROLOGY
(2021)
Article
Genetics & Heredity
Kate Stanley, Joseph Hostyk, Linh Tran, Marta Amengual-Gual, Patricia Dugan, Justice Clark, Hyunmi Choi, Dmitry Tchapyjnikov, Piero Perucca, Cecilia Fernandes, Danielle Andrade, Orrin Devinsky, Gianpiero L. Cavalleri, Chantal Depondt, Arjune Sen, Terence O'Brien, Erin Heinzen, Tobias Loddenkemper, David B. Goldstein, Mohamed A. Mikati, Norman Delanty
Summary: Large international consortia focusing on the genomic architecture of epilepsy examine large diagnostic subgroupings, but there are also smaller phenotypic subgroupings with unique genomic risk factors. The genetic structure of several microphenotypes was examined, with reports on two interesting clinical phenotypes.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2022)
Article
Clinical Neurology
Derek Neupert, Puya Abbassi, Lyndsey Prange, Robert Flamini, Mohamad A. Mikati
Summary: Mutations in the ATP1A3 gene can lead to various neurological syndromes, including alternating hemiplegia of childhood. This study reports on a case of a 10-year-old girl with the D801N ATP1A3 mutation, presenting with drug-resistant focal seizures and later developing electrical status epilepticus in sleep with generalized discharges and reversible epileptic encephalopathy.
EPILEPTIC DISORDERS
(2022)
Article
Orthopedics
J. A. Coppock, N. E. Zimmer, Z. A. Englander, S. T. Danyluk, A. S. Kosinski, C. E. Spritzer, A. P. Goode, L. E. DeFrate
Summary: This study investigated the in vivo relationship between mechanical response of intervertebral discs (IVDs) and IVD biochemical composition assessed via T1rho relaxation imaging. The results showed that increased IVD strain was associated with lower T1rho relaxation times in the nucleus pulposus (NP) of the disc, indicating an inverse relationship between IVD strain and NP composition.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Clinical Neurology
Piero Perucca, Kate Stanley, Natasha Harris, Anne M. McIntosh, Ali A. Asadi-Pooya, Mohamad A. Mikati, Danielle M. Andrade, Patricia Dugan, Chantal Depondt, Hyunmi Choi, Erin L. Heinzen, Gianpiero L. Cavalleri, Russell J. Buono, Orrin Devinsky, Michael R. Sperling, Samuel F. Berkovic, Norman Delanty, David B. Goldstein, Terence J. O'Brien
Summary: This study investigated whether rare genetic variations influence seizure outcomes of MTLE surgery. The results showed that MTLE cases carried a higher burden of ultrarare missense variants in constrained genes and genes encoding voltage-gated cation channels. However, these genetic variations did not have a major role in the failure of MTLE surgery.
ANNALS OF NEUROLOGY
(2023)
Letter
Behavioral Sciences
Mohamad A. Mikati, Julie Uchitel
JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
(2023)
Letter
Clinical Neurology
Eleni Panagiotakaki, Maria T. Papadopoulou, Gaetan Lesca, Alexis Arzimanoglou, Mohamad A. Mikati
Article
Clinical Neurology
Katrina Peariso, Ravindra S. Arya, Tracy Glauser, Nicholas Abend, Cristina Barcia Aguilar, Marta L. Amengual-Gual, Anne Anderson, Brian Appavu, J. Nicholas E. Brenton, Jessica Carpenter, Kevin D. Chapman, Justice Clark, William Gaillard, Marina Gainza-Lein, Joshua Goldstein, Howard M. Goodkin, Zachary S. Grinspan, Rejean Guerriero, Paul Horn, Linda A. Huh, Robert H. Kahoud, Sarah Kelley, Eric Kossoff, Kush Kapur, Yi-Chen Lai, B. Oyinkan A. Marquis, Tiffani McDonough, Mohamad Mikati, Lindsey P. Morgan, Edward T. Novotny, Adam Ostendorf, Eric Payne, Juan Piantino, James E. Riviello, Tristan C. Sands, Carl Stafstrom, Robert Tasker, Dmitry S. Tchapyjnikov, Alejandra Vasquez, Mark Wainwright, Angus Wilfong, Korwyn Williams, Tobias Loddenkemper, PSERG
Summary: This study aimed to identify patient-specific factors associated with the development of refractory convulsive status epilepticus (RSE) in children treated in emergency care. The study found that a family history of seizures and the use of rectal diazepam were associated with a decreased likelihood of RSE.
Letter
Clinical Neurology
Mohamad A. Mikati, Ghada El-Hajj Fuleihan
Letter
Clinical Neurology
Mohamad A. Mikati
Article
Clinical Neurology
Maria K. Sentmanat, Maria T. Papadopoulou, Lyndsey Prange, Carmen Fons, Elisa De Grandis, Aikaterini Vezyroglou, April Boggs, Samantha Su, Marion Comajuan, Jeffrey Wuchich, Sigurdur Johannesson, Jennifer Anticona Huaynate, Michela Stagnaro, Andrey Megvinov, Alexis Arzimanoglou, Rosaria Vavassori, Eleni Panagiotakaki, Mohamad A. Mikati
Summary: This study aimed to develop methods for recording Alternating Hemiplegia of Childhood (AHC) spells. The results showed that video-library training, event-calendar with weekly reviews, and e-Diary were effective tools for improving spell identification, ensuring consistent documentation, and encouraging long-term usage.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2023)
Article
Clinical Neurology
Shital H. Patel, Eleni Panagiotakaki, Maria T. Papadopoulou, Carmen Fons, Elisa De Grandis, Aikaterini Vezyroglou, Simona Balestrini, Hwanhee Hong, Beiyu Liu, Lyndsey Prange, Alexis Arzimanoglou, Rosaria Vavassori, Mohamad A. Mikati
Summary: This article describes the development process of a methodology for a multicenter natural history study of alternating hemiplegia of childhood, serving as a prototype disease for rare neurodevelopmental disorders. The authors employed a systematic approach to identify relevant questions, challenges, and appropriate methods to address them. The proposed solutions involve the development and standardization of specific tools, tailored measurement methods, unified data collection protocols, and specialized analysis methods.
JOURNAL OF CHILD NEUROLOGY
(2023)
Article
Clinical Neurology
Marta Amengual-Gual, Ivan Sanchez Fernandez, Alejandra Vasquez, Nicholas S. Abend, Anne Anderson, Ravindra Arya, Cristina Barcia Aguilar, J. Nicholas Brenton, Jessica L. Carpenter, Kevin E. Chapman, Justice Clark, Raquel Farias-Moeller, William D. Gaillard, Tracy A. Glauser, Joshua L. Goldstein, Howard P. Goodkin, Yi-Chen Lai, Mohamad A. Mikati, Lindsey A. Morgan, Edward J. Novotny, Adam P. Ostendorfr, Eric T. Payne, Katrina Peariso, Juan Piantino, Latania Reece, James J. Riviello, Kumar Sannagowdara, Theodore Sheehan, Robert C. Tasker, Dmitry Tchapyjnikov, Alexis A. Topjianv, Mark S. Wainwright, Angus Wilfong, Korwyn Williams, Tobias Loddenkemper
Summary: Delayed treatment in status epilepticus is associated with increased resistance, morbidity, and mortality. This study examines the prehospital management pathway and timeliness of Emergency Medical Services in children with refractory convulsive status epilepticus. The results indicate that a substantial number of patients did not receive any anti-seizure medication before arriving at the hospital, and patients with a history of seizures were more likely to receive prehospital treatment.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2023)
Article
Clinical Neurology
Ignacio Valencia, Allyson L. Alexander, Danielle M. Andrade, Miguel Arevalo-Astrada, Clio Rubinos, Nancy Auer, Jacquelyn L. Bainbridge, Sallie A. Baxendale, Fabrice Bartolomei, Danielle A. Becker, Anne T. Berg, Andrea Bernasconi, Neda Bernasconi, Boris Bernhardt, Shivani Bhatnagar, Ingmar Bluemcke, Hal Blumenfeld, Gordon F. Buchanan, David E. Burdette, Jorge G. Burneo, Robyn M. Busch, Patrick Chauvel, Jeannie Chin, Lisa Clifford, Kelly R. Conner, Mark J. Cook, Jeannine Conway, Ramon Diaz-Arastia, Cornelia Drees, Jacqueline A. French, Taneeta Mindy Ganguly, Michael A. Gelfand, Tracy A. Glauser, Ezequiel Gleichgerrcht, Alica M. Goldman, Jorge Gonzalez-Martinez, Jean Gotman, Zachary Grinspan, Shanna Guilfoyle, Gita Gupta, Michael Hammer, Adam L. Hartman, Katie Hentges, R. Edward Hogan, Linda Huh, Ann Hyslop, Barbara Jobst, Colin B. Josephson, Sarah A. Kelley, Kelly Knupp, Matthias Koepp, Sanjeev Kothare, Esther Krook-Magnuson, Jasmine Kwasa, Maite La Vega-Talbott, Alice D. Lam, Jong Woo Lee, Daniel H. Lowenstein, Sarita Maturu, Luis Carlos Mayor, Carrie McDonald, Heather R. McKee, Guy M. McKhann, Kimford J. Meador, Heather C. Mefford, Elizabeth H. Michael, Mohamad A. Mikati, John J. Millichap, James W. Mitchell, Leah S. Myers, Dean Naritoku, Kerri L. Neville, Jeffrey Noebels, Terence J. O'Brien, Chima O. Oluigbo, Anup D. Patel, Milena K. Pavlova, Jeanne T. Paz, Page B. Pennell, M. Scott Perry, Piero Perucca, Asla Pitkaenen, Madona Plueger, Mary Jo Pugh, Mark Quigg, Shilpa B. Reddy, Christopher Ryan, Tamara S. Reynolds, Martha Sajatovic, Cesar Santana-Gomez, Linsday Schommer, Stephan Schuele, Renee A. Shellhaas, Daniel W. Shrey, Rani K. Singh, Michael R. Sperling, Saher Suleman, Jessica W. Templer, Maria Thom, Eugen Trinka, Sophia M. Varadkar, Naymee Velez-Ruiz, Jana Veliskova, Yuliya Voskobiynyk, Janelle L. Wagner, Jacy L. Wagnon, Claire Waller, Jill Waller, Zhong Irene Wang, Michelle W. Welborn, Elaine Wirrell, Barbara Jobst
Summary: The American Epilepsy Society Meeting 2022 in Nashville attracted over 6000 attendees and felt as busy as before the pandemic. The meeting provided a variety of symposia covering topics such as seizure generation, epilepsy pathophysiology, anti-seizure medications, and new treatment tools. It also included discussions on epilepsy comorbidities, practical issues in epilepsy care, and personal stories from patient advocates. Special lectures and smaller group sessions focused on specific areas of interest, and satellite symposia showcased the latest advancements in pharmaceutical and engineering fields.
Article
Biochemistry & Molecular Biology
Eleni Panagiotakaki, Francesco D. Tiziano, Mohamad A. Mikati, Lisanne S. Vijfhuizen, Sophie Nicole, Gaetan Lesca, Emanuela Abiusi, Agnese Novelli, Lorena Di Pietro, Aster V. E. Harder, Nicole M. Walley, Elisa De Grandis, Anne-Lise Poulat, Vincent Des Portes, Anne Lepine, Marie-Cecile Nassogne, Alexis Arzimanoglou, Rosaria Vavassori, Jan Koenderink, Christopher H. Thompson, Alfred L. George, Fiorella Gurrieri, Arn M. J. M. van den Maagdenberg, Erin L. Heinzen
Summary: This study identified genetic variants in various neurodevelopmental genes, including SCN2A, that lead to AHC or AHC-like presentation in the majority of ATP1A3-negative patients. However, the genetic cause of some patients remains unknown, suggesting the involvement of other mutational mechanisms or oligo- or polygenic risk factors.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Scott Zheng, Minu-Tshyeto Bidzimou, Leonie Kurzlechner, Zhushan Zhang, Robin M. Perelli, Mary E. Moya-Mendez, Mohamad A. Mikati, Andrew P. Landstrom