Article
Biology
Akihiro Ikenaka, Yohko Kitagawa, Michiko Yoshida, Chuang-Yu Lin, Akira Niwa, Tatsutoshi Nakahata, Megumu K. Saito
Summary: Spinal muscular atrophy (SMA) is a congenital neuromuscular disease caused by the mutation or deletion of the survival motor neuron 1 (SMN1) gene. Recent studies have shown that SMA also involves skeletal muscle-specific pathological changes, such as impaired mitochondrial function and enhanced cell death. This study found that the down-regulation of SMN leads to mitochondrial dysfunction and cell death in skeletal myogenesis, and identified the SMN-miR axis as essential for myogenic metabolic maturation. In addition, supplementation of miRs can restore mitochondrial function and myotube formation in SMN-deficient cells and promote muscle contraction in ex vivo muscle stem cells.
LIFE SCIENCE ALLIANCE
(2023)
Article
Engineering, Biomedical
Yanqun Li, Jianhui Yue, Yuan Liu, Jun Wu, Min Guan, Di Chen, Haobo Pan, Xiaoli Zhao, William W. Lu
Summary: The study revealed that strontium promotes osteogenic differentiation of mesenchymal stem cells and balances stemness maintenance and osteogenic differentiation through asymmetric cell division. Strontium activates noncanonical Wnt signaling to regulate cell division and enhance osteogenic differentiation.
ACTA BIOMATERIALIA
(2021)
Article
Cell & Tissue Engineering
Filipa F. Ribeiro, Filipa Ferreira, Rui S. Rodrigues, Rita Soares, Diogo M. Pedro, Marta Duarte-Samartinho, Rita I. Aroeira, Elisabete Ferreiro, Jorge Valero, Susana Sola, Helena Mira, Ana M. Sebastiao, Sara Xapelli
Summary: The activation of A(2A) receptors promotes neural stem cell self-renewal, protects committed neuronal cells from cell death, and increases the density of immature and mature neuronal cells. Furthermore, the endogenous activation of A(2A) receptors is essential for BDNF-mediated cell proliferation and neuronal differentiation.
Review
Biochemistry & Molecular Biology
Raffaella Adami, Daniele Bottai
Summary: Studying neural stem cells (NSCs) from spinal muscular atrophy (SMA) patients is important for identifying new treatment targets and supporting affected patients. However, studying NSCs in living patients is challenging, but can be done using animal models or induced pluripotent stem cells. Therapeutic interventions like NSCs transplantation could improve SMA condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Qian Wei, Xia Hao, Benson Wui-Man Lau, Shaoxia Wang, Yue Li
Summary: Baicalin, as a main active ingredient in Radix Scutellariae, plays a significant role in regulating fate specification of stem cell populations, potentially improving the efficiency of stem cell therapy for climacteric syndrome.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Giulietta M. Riboldi, Irene Faravelli, Takaaki Kuwajima, Nicolas Delestree, Georgia Dermentzaki, Mariangels De Planell-Saguer, Paola Rinchetti, Le Thi Hao, Christine C. Beattie, Stefania Corti, Serge Przedborski, George Z. Mentis, Francesco Lotti
Summary: Sumoylation is crucial for the assembly and function of the SMN complex, and its loss impairs SMN's ability to correct specific deficits in the sensory-motor circuit of animal models of spinal muscular atrophy.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Vishnu Muraleedharan Saraswathy, Lili Zhou, Anthony R. McAdow, Brooke Burris, Deepika Dogra, Sven Reischauer, Mayssa H. Mokalled
Summary: This study reveals the dynamic expression of mstnb in dorsal spinal cord progenitors in zebrafish after injury. Mstnb mutants show impaired functional recovery, but normal glial and axonal bridging, and an increase in the number of newborn neurons at the lesion site. Treatment with human FGF1 rescues the molecular and cellular phenotypes of mstnb mutants.
Article
Cell Biology
Yue Hu, Jing Shao, Lanying Shen, Shengchao Wang, Kaiyan Xu, Jiayan Mao, Jian Shen, Wei Chen
Summary: This study demonstrates that adipose-derived mesenchymal stem cells (ADSCs) alleviate inflammatory responses and tissue damage in acute lung injury (ALI). Autophagy plays a key role in the therapeutic efficacy of ADSCs, and is regulated by the mammalian target of rapamycin (mTOR). These findings provide important insights into the therapeutic strategy paradigm for ALI.
CELL DEATH DISCOVERY
(2022)
Article
Entomology
Jiewei Wang, Qiang Liu, Yuan Gong, Li Hua Jin
Summary: The adult Drosophila intestinal epithelium is tightly regulated by the G protein-coupled receptor Anchor to maintain homeostasis. Inactivation of anchor leads to aberrant activation of the JNK and Notch pathways, affecting stem cell differentiation and proliferation, ultimately causing sensitivity to environmental challenges.
JOURNAL OF INSECT PHYSIOLOGY
(2021)
Article
Cell Biology
Jinping Huang, Xiao Sheng, Zhangpeng Zhuo, Danqing Xiao, Kun Wu, Gang Wan, Haiyang Chen
Summary: This study identifies ClC-c as a regulator of intestinal stem cell proliferation in Drosophila, providing new insights into the functional relationship between chloride channels, stem cell maintenance, and tissue homeostasis.
CELL PROLIFERATION
(2022)
Article
Biochemistry & Molecular Biology
Wei-Fang Chang, Min Peng, Jing Hsu, Jie Xu, Huan-Chieh Cho, Hsiu-Mei Hsieh-Li, Ji-Long Liu, Chung-Hao Lu, Li-Ying Sung
Summary: SMN is crucial for RNA spliceosome assembly and plays important roles in stem cell biology. Overexpression of SMN enhances the proliferation and potency of SSCs, positively influencing spermatogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Yan Hu, Yan Hou, Shijie Zhou, Yingzhi Wang, Congcong Shen, Li Mu, Dan Su, Rundong Zhang
Summary: This study reconstituted the chaperone machinery using recombinant proteins and investigated their roles systematically. The findings reveal differences in the spliceosomal assembly between Schizosaccharomyces pombe and humans.
Article
Clinical Neurology
Stefano Zoccolella, Alessandro Introna, Giammarco Milella, Antonella Mastronardi, Giovanni Iliceto, Eustachio D'Errico, Angela Fraddosio, Isabella Laura Simone
Summary: This study aimed to evaluate a cohort of LMNP patients and found that TMS abnormalities did not impact survival time but accelerated disease progression, leading to a faster progression to King's 4 stage.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Cell Biology
Marcia Garcez, Joana Branco-Santos, Patricia C. Gracio, Catarina C. F. Homem
Summary: This study characterized the role of mitochondria morphology in female germ stem cells, showing that undifferentiated GSCs predominantly have fissed mitochondria, while more differentiated cells have more fused mitochondria. The findings emphasize the essential requirement of mitochondrial dynamics for maintaining a stable GSC pool.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Atsuo Nakamura, Shin Kurihara, Daisuke Takahashi, Wakana Ohashi, Yutaka Nakamura, Shunsuke Kimura, Masayoshi Onuki, Aiko Kume, Yukiko Sasazawa, Yukihiro Furusawa, Yuuki Obata, Shinji Fukuda, Shinji Saiki, Mitsuharu Matsumoto, Koji Hase
Summary: This study reveals that polyamines produced by intestinal bacteria have beneficial effects on enhancing colonic barrier function and immunity by increasing regulatory macrophage abundance and being taken up by colonic epithelial cells.
NATURE COMMUNICATIONS
(2021)