Article
Neurosciences
Vandre C. Figueiredo, Yuan Wen, Bjorn Alkner, Rodrigo Fernandez-Gonzalo, Jessica Norrbom, Ivan J. Vechetti, Taylor Valentino, C. Brooks Mobley, Gabriel E. Zentner, Charlotte A. Peterson, John J. McCarthy, Kevin A. Murach, Ferdinand von Walden
Summary: The study reveals the genetic and rDNA gene-wide epigenetic regulation of ribosome biogenesis in response to exercise, highlighting the roles of rDNA dosage and CpG methylation in skeletal muscle. This indicates a genetic predisposition for hypertrophic responsiveness and preferential up-regulation of ribosome biogenesis with resistance exercise. The findings expand our understanding of the genetic and epigenetic factors involved in exercise-induced changes in ribosome biogenesis.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Plant Sciences
Daniel Matsusaka, Javier F. Botto, Diego H. Sanchez
Summary: This study reveals the central regulatory role of specific noncoding tandem repeats in the intersection between epigenetic silencing and gene expression, and their importance in plant stress responses.
PHYSIOLOGIA PLANTARUM
(2022)
Review
Biochemistry & Molecular Biology
Shanshan Sun, Feng Yu, Danying Xu, Haiyan Zheng, Min Li
Summary: This review summarizes the dynamic functions of the histone methyltransferase EZH2 in the tumor microenvironment, including its regulation of tumor cells, immune cells, and other components of the TME. The potential of combination therapy to enable immune checkpoint blockade in cancer treatment is also discussed.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Review
Cell Biology
Anirudh Pillai, Akhila Gungi, Puli Chandramouli Reddy, Sanjeev Galande
Summary: Studying cnidarians like Hydra can enhance our understanding of the evolutionary foundations underlying eumetazoan tissue development, homeostasis, and regeneration. These organisms exhibit unique regenerative potential and continuously active axial patterning, necessitating large-scale gene expression changes governed by a variety of epigenetic mechanisms within cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Erica B. Esrick, Leslie E. Lehmann, Alessandra Biffi, Maureen Achebe, Christian Brendel, Marioara F. Ciuculescu, Heather Daley, Brenda MacKinnon, Emily Morris, Amy Federico, Daniela Abriss, Kari Boardman, Radia Khelladi, Kit Shaw, Helene Negre, Olivier Negre, Sarah Nikiforow, Jerome Ritz, Sung-Yun Pai, Wendy B. London, Colleen Dansereau, Matthew M. Heeney, Myriam Armant, John P. Manis, David A. Williams
Summary: This study confirms BCL11A inhibition as an effective approach for inducing HbF in sickle cell disease. Preliminary evidence suggests that shmik-based gene knockdown offers a favorable risk-benefit profile in treating sickle cell disease.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Immunology
Ravesh Singh, Veron Ramsuran, Vivek Naranbhai, Nonhlanhla Yende-Zuma, Nigel Garrett, Koleka Mlisana, Krista L. Dong, Bruce D. Walker, Salim S. Abdool Karim, Mary Carrington, Thumbi Ndungu
Summary: Elevated levels of BST-2 may be associated with viral control in HIV-infected females, and DNA methylation plays a role in regulating BST-2 levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
You-Wei Wang, Nan Hu, Xiao-Hong Li
Summary: Revealing the mechanisms of neural development and neural diseases is a challenging task in life science. Brain organoids derived from pluripotent stem cells can mimic the development, function, and signal generation of human brains, providing a unique advantage for studying neurology. Single-cell RNA sequencing and multielectrode array analysis have shown the similarity between brain organoids and the immature human brain at early developmental stages.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Shawn Ying Xuan Tan, Jieqiong Zhang, Wee-Wei Tee
Summary: This review discusses the interplay between epigenetics and inflammation. External and internal microenvironments contribute to epigenetic processes, and dysregulation of these processes can lead to cancer. Chronic inflammation plays a crucial role in the tumor microenvironment, and inflammatory signaling can modulate changes in the global epigenetic landscape.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Plant Sciences
Lina Castano-Duque, Sharmistha Ghosal, Fergie A. Quilloy, Thomas Mitchell-Olds, Shalabh Dixit
Summary: This study investigated the genetic basis of anaerobic germination in rice, identifying it as a polygenic trait associated with transcription factors linked to ethylene responses and genes involved in metabolic processes. Further functional analysis focused on small RNA and methylation pathways, revealing the involvement of the RNA-directed DNA methylation (RdDm) pathway in rice responses to water status during germination and seedling establishment developmental stages.
Article
Biochemistry & Molecular Biology
Gaurab Roy, Ting Yang, Shangxin Liu, Yi-Ling Luo, Yuantao Liu, Qian Zhong
Summary: This study identifies MAP3K8 as a super-enhancer (SE)-associated gene in Epstein-Barr virus-associated gastric carcinoma (EBVaGC) cells. Repression of MAP3K8 SEs reduces MAP3K8 expression and inhibits EBVaGC cell proliferation. It is found that MAP3K8 inhibits the Notch signaling pathway and epithelial-mesenchymal transition (EMT) in EBVaGC. Moreover, increased MAP3K8 expression is observed in gastric cancer and is inversely correlated with disease-free progression, while positively correlated with the expressions of Notch pathway and EMT-related genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Environmental Sciences
Dong Li, Yan Yang, Youping Li, Xiaohua Zhu, Zeqin Li
Summary: Environmental exposure can lead to changes in epigenetic regulation, affecting gene expression. Studies have shown that histone modifications, DNA methylation, RNA modifications, and non-coding RNA expression play important roles in this process.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Medicine, Research & Experimental
Zheng Wang, Shuangfei Ni, Huafeng Zhang, Yonggang Fan, Lei Xia, Ning Li
Summary: This study elucidates the mechanism by which SGK1 is involved in the progression of osteoarthritis, showing that it inhibits CREB1 expression in chondrocytes, leading to inflammation and suppression of chondrocyte proliferation. CREB1 is positively correlated with ABCA1 expression, and down-regulation of CREB1 inhibits cell proliferation and exacerbates inflammation, which can be reversed by overexpression of ABCA1.
Article
Biology
Teresa Romeo Luperchio, Leandros Boukas, Li Zhang, Genay Pilarowski, Jenny Jiang, Allison Kalinousky, Kasper D. Hansen, Hans T. Bjornsson
Summary: The study reveals shared epigenetic alterations in different MDEM diseases, primarily localized in gene promoters, which may disrupt gene expression and contribute to specific phenotypes, such as IgA deficiency. Joint study of MDEMs offers a systematic approach for mapping functional epigenetic variation in mammals.
Article
Biotechnology & Applied Microbiology
Francisco Rodriguez-Algarra, Robert A. E. Seaborne, Amy F. Danson, Selin Yildizoglu, Harunori Yoshikawa, Pui Pik Law, Zakaryya Ahmad, Victoria A. Maudsley, Ama Brew, Nadine Holmes, Mateus Ochoa, Alan Hodgkinson, Sarah J. Marzi, Madapura M. Pradeepa, Matthew Loose, Michelle L. Holland, Vardhman K. Rakyan
Summary: This study reveals the existence of genetic haplotypes in rDNA units of C57BL/6J mice, which influence the epigenetic state and transcriptional output of these units. However, human rDNA units show limited evidence of genetic haplotypes. Additionally, adjacent units in different species show similar epigenetic profiles, and the overall epigenetic state at rDNA is strongly positively correlated with the total rDNA copy number.
Article
Multidisciplinary Sciences
Sindhuja Devanapally, Pravrutha Raman, Mary Chey, Samual Allgood, Farida Ettefa, Maigane Diop, Yixin Lin, Yongyi E. Cho, Antony M. Jose
Summary: Stable epigenetic changes are relatively rare. The authors report that mating induces stable silencing of a single-copy transgene in C. elegans. Components of small RNA silencing are required for this stable silencing.
NATURE COMMUNICATIONS
(2021)