Article
Biochemistry & Molecular Biology
Laurel Watkins de Jong, Mohammadreza Mohagheghi Nejad, Euisik Yoon, Sen Cheng, Kamran Diba
Summary: Recurrent connectivity and feedback inhibition from inhibitory neurons play crucial roles in determining the dynamics and computational properties of neuronal circuits. Through optogenetic manipulations and large-scale unit recordings, paradoxical responses were observed in both CA1 and CA3 regions of the hippocampus, where subsets of cells increased firing during photoinhibition while others decreased firing during photoexcitation. These paradoxical responses were more prominent in CA3 and simulations confirmed that both CA1 and CA3 hippocampal regions exhibit inhibition-stabilized networks with strong recurrent excitation.
Article
Neurosciences
Tobias Bock, Adrian Negrean, Steven A. Siegelbaum
Summary: Synaptic inputs targeting distal dendrites can amplify local dendritic spikes, but these spikes are often weak due to dendritic cable properties. Despite this, they are implicated in memory storage, sensory perception, and place field formation. Somatic depolarization can enhance dendritic spike propagation, leading to enhanced memory specificity and long-term synaptic plasticity in hippocampal-dependent spatial representations and learning.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Yael Almog, Saja Fadila, Marina Brusel, Anat Mavashov, Karen Anderson, Moran Rubinstein
Summary: Dravet syndrome is a rare and severe childhood-onset epilepsy caused by mutations in the SCN1A gene. Studies on Dravet mice showed persistent reduced function in inhibitory neurons and changes in excitatory neurons during different disease stages. This suggests a complex pathophysiological mechanism with reciprocal functional changes in both excitatory and inhibitory neurons influencing the developmental trajectory of the disease.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
Sebi Rolotti, Heike Blockus, Fraser T. Sparks, James B. Priestley, Attila Losonczy
Summary: The hippocampus plays a critical role in memory consolidation, particularly during sharp-wave ripple (SWR) events. This study investigated the relationship between network state and information processing in dendrites, the primary sites of synaptic input integration and plasticity. The researchers found that immobility led to increased dendritic activity, which was concentrated during SWR events. Concurrent dendritic and somatic activity during SWRs predicted increased coupling during subsequent exploration of a novel environment. Somatic-dendritic coupling and SWR recruitment also varied based on cells' tuning distance to reward location during a goal-learning task.
Article
Biochemistry & Molecular Biology
Tae-Kyeong Lee, Myoung Cheol Shin, Ji Hyeon Ahn, Dae Won Kim, Bora Kim, Hyejin Sim, Jae-Chul Lee, Jun Hwi Cho, Joon Ha Park, Young-Myeong Kim, Moo-Ho Won, Choong-Hyun Lee
Summary: This study investigated the time-dependent changes in CD200 expression in the hippocampus after transient forebrain ischemia in gerbils. The results showed that transient ischemia led to specific and selective neuronal death in the CA1 field, with CD200 expression changing over time. Interestingly, treatment with risperidone did not alter CD200 expression, indicating protection of CA1 pyramidal neurons from ischemic injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Lingjun Ding, Giuseppe Balsamo, Hongbiao Chen, Eduardo Blanco-Hernandez, Ioannis S. Zouridis, Robert Naumann, Patricia Preston-Ferrer, Andrea Burgalossi
Summary: Neural circuits are composed of diverse neuronal cell types, and this diversity plays a crucial role in brain function during natural behavior. In this study, the combination of juxtacellular recording, labeling, and optogenetics enabled the investigation of molecularly defined cell classes in freely moving mice, revealing the weaker spatial modulation and information transmission of Calbindin-positive CA1 pyramidal cells.
Article
Biochemical Research Methods
Adam Ponzi, Salvador Dura-Bernal, Michele Migliore
Summary: Oscillations are a common feature of brain operations and are found across different animal species. These oscillations appear in discrete frequencies and are coupled, with the phase of one oscillation modulating the amplitude of another. However, the biophysical origin and reasons for the ubiquity of these oscillations remain unclear. Using a data-driven computational model, researchers demonstrate how a basic microcircuit can generate phase-amplitude coupled oscillations, suggesting a general underlying mechanism.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Review
Neurosciences
Alexandra Tzilivaki, John J. Tukker, Nikolaus Maier, Panayiota Poirazi, Rosanna P. Sammons, Dietmar Schmitz
Summary: This article explores the brain's ability to capture and store information, focusing on the types, plasticity, and activity patterns of interneurons in the hippocampus and their impact on memory processing.
Article
Cell Biology
Mark Rigby, Federico W. Grillo, Benjamin Compans, Guilherme Neves, Julia Gallinaro, Sophie Nashashibi, Sally Horton, Pedro M. Pereira Machado, Maria Alejandra Carbajal, Gema Vizcay-Barrena, Florian Levet, Jean-Baptiste Sibarita, Angus Kirkland, Roland A. Fleck, Claudia Clopath, Juan Burrone
Summary: Using scanning electron microscopy, researchers found that excitatory synapses in the hippocampus CA1 region do not fully adhere to the traditional definition. Over half of the excitatory synapses are multi-synaptic boutons, where a single presynaptic bouton can connect to multiple postsynaptic spines on different dendrites. The proportion of multi-synaptic boutons changes during development and with distance from the cell body. These structures exhibit less variability in synaptic properties compared to single synaptic boutons, promoting synchronous activity.
Article
Neurosciences
Ipshita Zutshi, Manuel Valero, Antonio Fernandez-Ruiz, Gyorgy Buzsaki
Summary: The extent to which neuronal spiking reflects local computation or responses to upstream inputs in circuit operations is a key problem in understanding. By performing experiments on the hippocampus, this study revealed that silencing the medial entorhinal cortex (mEC) largely abolished theta and gamma currents in CA1, while CA3 and local CA1 silencing strongly decreased firing of CA1 neurons. Despite these perturbations, the CA1 circuit was still able to support place field activity and maintain the spatial map.
Article
Cell Biology
Junfeng Su, Fengwen Huang, Yu Tian, Ran Tian, Qianqian Gao, Stephen Temitayo Bello, Dingxaun Zeng, Peter Jendrichovsky, C. Geoffrey Lau, Wenjun Xiong, Daiguan Yu, Micky Tortorella, Xi Chen, Jufang He
Summary: This study reveals the critical role of cholecystokinin (CCK) in heterosynaptic neuromodulation from the medial entorhinal cortex (MEC) to the hippocampus, affecting CA3-CA1 LTP and space-related performance.
Article
Multidisciplinary Sciences
Manuel Valero, Ipshita Zutshi, Euisik Yoon, Gyorgy Buzsaki
Summary: This study used optogenetic pulses to investigate the subthreshold dynamics of hippocampal neuronal assemblies. The results showed that excitability decreased during sharp-wave ripples accompanied by increased inhibition. However, optogenetic probing revealed increased excitability in place cells by weakening inhibition, unmasking stable place fields in initially non-place cells. Neuronal assemblies active during sharp-wave ripples in the home cage predicted spatial overlap and sequences of place fields in both place cells and unmasked preexisting place fields of non-place cells during track running.
Article
Neurosciences
Pablo Vergara, Gabriela Pino, Jorge Vera, Felipe Arancibia, Magdalena Sanhueza
Summary: Prolonged changes in neural activity trigger homeostatic synaptic plasticity, allowing neuronal networks to operate within functional ranges. Deafferentation causes rapid and diverse compensations, which may contribute to understanding homeostatic or pathological events after brain injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Anurag Singh, Shruthi Sateesh, Owen D. Jones, Wickliffe C. Abraham
Summary: The study revealed a pathway specificity for the heterodendritic metaplasticity in CA1, where Schaffer collateral/commissural synapses in the stratum radiatum were particularly sensitive to the inhibitory effects of high-frequency priming stimulation mediated by tumor necrosis factor (TNF). The metaplasticity effects were absent in TNFR1 knock-out mice, indicating a dependence on TNF regulation. This suggests an important control of information processing in this pathway, along with potential implications for neuroinflammation sensitivity under disease conditions.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Lujia Chen, Xiaoxiao Lin, Qiao Ye, Zoran Nenadic, Todd C. Holmes, Douglas A. Nitz, Xiangmin Xu
Summary: Hippocampal CA1 neuronal ensembles generate sequential patterns of firing activity that contribute to episodic memory formation and spatial cognition. We recorded neural ensemble activities in mouse hippocampal CA1 using in vivo calcium imaging and identified sub-populations that are active at the same time. These sub-populations organize as clusters in anatomical space and vary in membership and activity dynamics in different environments. The covariance between dynamics and anatomical location reveals a topographic representation that may guide the generation of hippocampal sequences and organize episodic memory content.
Article
Biochemical Research Methods
Sara Saray, Christian A. Roessert, Shailesh Appukuttan, Rosanna Migliore, Paola Vitale, Carmen A. Lupascu, Luca L. Bologna, Werner Van Geit, Armando Romani, Andrew P. Davison, Eilif Muller, Tamas F. Freund, Szabolcs Kali
Summary: Anatomically and biophysically detailed data-driven neuronal models are widely used for understanding and predicting neuron behavior. However, there is a lack of methods to quantitatively compare different models or test their behavior in various contexts. To address this, a Python test suite was developed for comparing and evaluating the behavior of models against experimental data, focusing on the CA1 pyramidal cell of the rat hippocampus. This approach was demonstrated to be useful in improving model accuracy and aiding in the development of neural models within the European Human Brain Project.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Neurosciences
Tomas J. Ryan, Clara Ortega-de San Luis, Maurizio Pezzoli, Siddhartha Sen
Summary: Understanding memory storage involves explaining how information is stored in the brain in a stable state, known as an engram. Recent research suggests that memory and instinct may be represented as isomorphic topological structures in the brain's microanatomical circuitry.
CURRENT OPINION IN NEUROBIOLOGY
(2021)
Article
Biophysics
Daniela Bianchi, Rosanna Migliore, Paola Vitale, Machhindra Garad, Paula A. Pousinha, Helene Marie, Volkmar Lessmann, Michele Migliore
Summary: This paper highlights an electrophysiological feature observed in mouse CA1 pyramidal cells that has been ignored by researchers. The increase in membrane potential during sustained inputs cannot be explained by current computational models. A new model is proposed to address this issue.
BIOPHYSICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Giuseppe Chindemi, Marwan Abdellah, Oren Amsalem, Ruth Benavides-Piccione, Vincent Delattre, Michael Doron, Andras Ecker, Aurelien T. Jaquier, James King, Pramod Kumbhar, Caitlin Monney, Rodrigo Perin, Christian Roessert, Anil M. Tuncel, Werner Van Geit, Javier DeFelipe, Michael Graupner, Idan Segev, Henry Markram, Eilif B. Muller
Summary: This study introduces a model of synaptic plasticity based on data-constrained calcium dynamics, and demonstrates that a single parameter set can explain the experimental findings on long-term potentiation (LTP) and long-term depression (LTD) of pyramidal cell (PC) connections in the neocortex. The study also predicts different plasticity dynamics in vivo compared to in vitro, and provides a framework for further modeling cortical synaptic plasticity.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Lida Kanari, Hugo Dictus, Athanassia Chalimourda, Alexis Arnaudon, Werner Van Geit, Benoit Coste, Julian Shillcock, Kathryn Hess, Henry Markram
Summary: Neuronal morphologies play a crucial role in the electrical behavior of neurons, connectomes, and brain dynamics. This paper proposes a synthesis algorithm based on a topological descriptor of neurons, allowing the rapid reconstruction of entire brain regions from a few reference cells. The synthesized morphologies exhibit statistical similarity to biological reconstructions in terms of their morpho-electrical and connectivity properties, providing a valuable opportunity to study the relationship between neuronal morphology and brain function across different spatial and temporal scales.
Article
Cell Biology
Anirban Nandi, Thomas Chartrand, Werner Van Geit, Anatoly Buchin, Zizhen Yao, Soo Yeun Lee, Yina Wei, Brian Kalmbach, Brian Lee, Ed Lein, Jim Berg, Uygar Sumbul, Christof Koch, Bosiljka Tasic, Costas A. Anastassiou
Summary: This article introduces a computational optimization workflow to generate single-neuron models, aiming to explore the relationship between cell types constituting brain circuits and electrophysiological experiments.
Article
Computer Science, Interdisciplinary Applications
Shailesh Appukuttan, Luca L. Bologna, Felix Schurmann, Michele Migliore, Andrew P. Davison
Summary: This article presents an online platform for sharing resources related to neuroscience publications, allowing easy uploading, distribution, and interactivity with the resources through features like downloading, visualizing, and simulating data and models.
Article
Mathematical & Computational Biology
Luca Leonardo Bologna, Roberto Smiriglia, Carmen Alina Lupascu, Shailesh Appukuttan, Andrew P. Davison, Genrich Ivaska, Jean-Denis Courcol, Michele Migliore
Summary: This article introduces the EBRAINS Hodgkin-Huxley Neuron Builder (HHNB), a web resource for building single cell neural models. It allows the extraction of electrophysiological features, optimization of model parameters, and simulation of the optimized model, promoting a collaborative and reproducible approach to data-driven brain modeling.
FRONTIERS IN NEUROINFORMATICS
(2022)
Correction
Cell Biology
Anirban Nandi, Thomas Chartrand, Werner Van Geit, Anatoly Buchin, Zizhen Yao, Soo Yeun Lee, Yina Wei, Brian Kalmbach, Brian Lee, Ed Lein, Jim Berg, Uygar Sumbul, Christof Koch, Bosiljka Tasic, Costas A. Anastassiou
Article
Multidisciplinary Sciences
Yina Wei, Anirban Nandi, Xiaoxuan Jia, Joshua H. Siegle, Daniel Denman, Soo Yeun Lee, Anatoly Buchin, Werner Van Geit, Clayton P. Mosher, Shawn Olsen, Costas A. Anastassiou
Summary: Understanding the functional roles of different types of neurons is difficult. In this study, the authors linked the multi-modal in vitro cell properties with the in vivo physiology of the mouse visual cortex. They used computational modeling and optotagging experiments to connect the cellular properties measured in vitro with the in vivo recorded units, and discovered distinct in vivo properties for different clusters in the mouse visual cortex. Biophysical models were used to map these clusters to specific in vitro classes, explaining their unique extracellular signatures and functional characteristics. Optotagging experiments confirmed these findings and demonstrated the power of this multi-modal approach in inferring cellular properties from first principles.
NATURE COMMUNICATIONS
(2023)
Article
Computer Science, Information Systems
Gilad Shapira, Mira Marcus-Kalish, Oren Amsalem, Werner Van Geit, Idan Segev, David M. Steinberg
Summary: Many scientific systems are studied using computer simulation, including in neuroscience. This work applies statistical emulation to simulations of neocortical cells and introduces the use of fast empirical emulators to accelerate the optimization process of the simulator.
FRONTIERS IN BIG DATA
(2022)
Meeting Abstract
Mathematical & Computational Biology
Maria Reva, Christian Roessert, Darshan Mandge, Alexis Arnaudon, Tanguy Damart, Mustafa Anil Tuncel, Srikanth Ramaswamy, Werner Van Geit, Henry Markram
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
(2021)
Meeting Abstract
Mathematical & Computational Biology
Joseph Tharayil, Mickael Zbili, Alexis Arnaudon, Werner Van Geit, Esra Neufeld, Michael Reimann, Felix Schuermann, Henry Markram
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
(2021)