Investigating the Structure and Dynamics of the PIK3CA Wild-Type and H1047R Oncogenic Mutant
出版年份 2014 全文链接
标题
Investigating the Structure and Dynamics of the PIK3CA Wild-Type and H1047R Oncogenic Mutant
作者
关键词
-
出版物
PLoS Computational Biology
Volume 10, Issue 10, Pages e1003895
出版商
Public Library of Science (PLoS)
发表日期
2014-10-24
DOI
10.1371/journal.pcbi.1003895
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The Different Flexibility of c-Src and c-Abl Kinases Regulates the Accessibility of a Druggable Inactive Conformation
- (2012) Silvia Lovera et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110 (PIK3CA)
- (2012) J. E. Burke et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Luminal Expression of PIK3CA Mutant H1047R in the Mammary Gland Induces Heterogeneous Tumors
- (2011) D. S. Meyer et al. CANCER RESEARCH
- Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism
- (2011) Xuxiao Zhang et al. MOLECULAR CELL
- Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases
- (2011) W-C Hon et al. ONCOGENE
- Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases
- (2011) Oscar Vadas et al. Science Signaling
- The PI3K Pathway As Drug Target in Human Cancer
- (2010) Kevin D. Courtney et al. JOURNAL OF CLINICAL ONCOLOGY
- Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34
- (2010) S. Miller et al. SCIENCE
- Form and flexibility in phosphoinositide 3-kinases
- (2009) Roger Williams et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- CHARMM: The biomolecular simulation program
- (2009) B. R. Brooks et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- A frequent kinase domain mutation that changes the interaction between PI3K and the membrane
- (2009) D. Mandelker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Detection of Functional Modes in Protein Dynamics
- (2009) Jochen S. Hub et al. PLoS Computational Biology
- Effects of oncogenic p110α subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase
- (2008) Jeffrey D. Carson et al. BIOCHEMICAL JOURNAL
- GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation
- (2008) Berk Hess et al. Journal of Chemical Theory and Computation
- Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
- (2008) Jeffrey A Engelman et al. NATURE MEDICINE
- PI3K pathway alterations in cancer: variations on a theme
- (2008) T L Yuan et al. ONCOGENE
- Helical domain and kinase domain mutations in p110 of phosphatidylinositol 3-kinase induce gain of function by different mechanisms
- (2008) L. Zhao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PIK3CA somatic mutations in breast cancer: Mechanistic insights from Langevin dynamics simulations
- (2008) Parminder K. Mankoo et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started