Possible Role of Interleukin-1β in Type 2 Diabetes Onset and Implications for Anti-inflammatory Therapy Strategies

Double-Blind, Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1  Antibody, in Patients With Type 2 Diabetes

(2013) J. Sloan-Lancaster et al.   DIABETES CARE

Evaluation of a mathematical model of diabetes progression against observations in the Diabetes Prevention Program

(2012) Thomas Hardy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling

(2012) A. V. Matveyenko et al.   DIABETES

Effects of Gevokizumab on Glycemia and Inflammatory Markers in Type 2 Diabetes

(2012) C. Cavelti-Weder et al.   DIABETES CARE

Effect of anti-IL-1β antibody (canakinumab) on insulin secretion rates in impaired glucose tolerance or type 2 diabetes: results of a randomized, placebo-controlled trial

(2012) A. Rissanen et al.   DIABETES OBESITY & METABOLISM

Effect of regression from prediabetes to normal glucose regulation on long-term reduction in diabetes risk: results from the Diabetes Prevention Program Outcomes Study

(2012) Leigh Perreault et al.   LANCET

Perspective: Testing failures

(2012) Thomas Mandrup-Poulsen   NATURE

Metformin Prevents and Reverses Inflammation in a Non-Diabetic Mouse Model of Nonalcoholic Steatohepatitis

(2012) Yuki Kita et al.   PLoS One

Effect of Diacerein on Insulin Secretion and Metabolic Control in Drug-Naive Patients With Type 2 Diabetes: A randomized clinical trial

(2011) M. G. Ramos-Zavala et al.   DIABETES CARE

Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC Study

(2011) E. Ferrannini et al.   DIABETOLOGIA

Treatment with Anakinra Improves Disposition Index But Not Insulin Sensitivity in Nondiabetic Subjects with the Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study

(2011) Edwin J. P. van Asseldonk et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Role of IL-1β in type 2 diabetes

(2011) Charles A Dinarello et al.   Current Opinion in Endocrinology Diabetes and Obesity

The Stunned β Cell: A Brief History

(2010) Ele Ferrannini   Cell Metabolism

Accelerated Increase in Serum Interleukin-1 Receptor Antagonist Starts 6 Years Before Diagnosis of Type 2 Diabetes: Whitehall II Prospective Cohort Study

(2010) M. Carstensen et al.   DIABETES

Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance

(2010) A. Mari et al.   DIABETOLOGIA

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus

(2009) R. A. DeFronzo   DIABETES

Pleiotropic Action of Short-Term Metformin and Fenofibrate Treatment, Combined With Lifestyle Intervention, in Type 2 Diabetic Patients With Mixed Dyslipidemia

(2009) M. Pruski et al.   DIABETES CARE

Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes

(2009) C. M. Larsen et al.   DIABETES CARE

Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival

(2009) R. Glas et al.   DIABETOLOGIA

Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I

(2009) Marianne Böni-Schnetzler et al.   ENDOCRINOLOGY

Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study

(2009) Adam G Tabák et al.   LANCET

Mathematical models of diabetes progression

(2008) Andrea De Gaetano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

β-cell failure in type 2 diabetes mellitus

(2008) Cristina Lencioni et al.   Current Diabetes Reports

 - and  -Cell Dysfunction in Subjects Developing Impaired Glucose Tolerance: Outcome of a 12-Year Prospective Study in Postmenopausal Caucasian Women

(2008) B. Ahren   DIABETES

Pancreatic β-cell mass in European subjects with type 2 diabetes

(2008) J. Rahier et al.   DIABETES OBESITY & METABOLISM

Cytokines and β-Cell Biology: from Concept to Clinical Translation

(2008) Marc Y. Donath et al.   ENDOCRINE REVIEWS

Increased Interleukin (IL)-1β Messenger Ribonucleic Acid Expression in β-Cells of Individuals with Type 2 Diabetes and Regulation of IL-1β in Human Islets by Glucose and Autostimulation

(2008) Marianne Böni-Schnetzler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Intensive insulin therapy in newly diagnosed type 2 diabetes

(2008) Ravi Retnakaran et al.   LANCET

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

(2008) Deborah M. Muoio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY