Phenome-Wide Association Studies on a Quantitative Trait: Application to TPMT Enzyme Activity and Thiopurine Therapy in Pharmacogenomics

Poor Response to Thiopurine in Inflammatory Bowel Disease: How to Overcome Therapeutic Resistance?

(2013) L. Chouchana et al.   CLINICAL CHEMISTRY

Nomenclature for alleles of the thiopurine methyltransferase gene

(2013) Malin L. Appell et al.   Pharmacogenetics and Genomics

Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network

(2013) Sarah A. Pendergrass et al.   PLoS Genetics

Clinical Bioinformatics: challenges and opportunities

(2012) Riccardo Bellazzi et al.   BMC BIOINFORMATICS

Translational Bioinformatics: Linking the Molecular World to the Clinical World

(2012) R B Altman   CLINICAL PHARMACOLOGY & THERAPEUTICS

TPMT status determination: The simplest is the most effective?

(2012) Laurent Chouchana et al.   Journal of Crohns & Colitis

The coming age of data-driven medicine: translational bioinformatics' next frontier

(2012) N. H. Shah et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

A Glimpse of the Next 100 Years in Medicine

(2012) Isaac S. Kohane et al.   NEW ENGLAND JOURNAL OF MEDICINE

Applying semantic web technologies for phenome-wide scan using an electronic health record linked Biobank

(2012) Jyotishman Pathak et al.   Journal of Biomedical Semantics

Review article: the benefits of pharmacogenetics for improving thiopurine therapy in inflammatory bowel disease

(2011) L. Chouchana et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Variants Near FOXE1 Are Associated with Hypothyroidism and Other Thyroid Conditions: Using Electronic Medical Records for Genome- and Phenome-wide Studies

(2011) Joshua C. Denny et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing

(2011) M V Relling et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery

(2011) S.A. Pendergrass et al.   GENETIC EPIDEMIOLOGY

PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations

(2010) J. C. Denny et al.   BIOINFORMATICS

Serving the enterprise and beyond with informatics for integrating biology and the bedside (i2b2)

(2010) S. N. Murphy et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Effective knowledge management in translational medicine

(2010) Sándor Szalma et al.   Journal of Translational Medicine

Genomic Medicine — An Updated Primer

(2010) W. Gregory Feero et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prevalence and pathogenesis of anemia in inflammatory bowel disease. Influence of anti-tumor necrosis factor-  treatment

(2009) G. Bergamaschi et al.   HAEMATOLOGICA

The Unreasonable Effectiveness of Data

(2009) Alon Halevy et al.   IEEE INTELLIGENT SYSTEMS

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA