Review
Polymer Science
Brielle Stawicki, Tyler Schacher, Hyunah Cho
Summary: Chemotherapy and radiation are mainstays in cancer treatment globally, but some therapies have limited specificity and cause harsh side effects in patients. Nanogels, as a unique drug delivery system, show promise in the treatment of brain cancer, despite complications such as handling and chemical stability. Ongoing development of nanogels offers a patient-centered approach for managing brain cancer.
Article
Biochemistry & Molecular Biology
Sivagangi Reddy Nagella, Soojeong Choi, Soo-Yong Park, Chang-Sik Ha, Youngmi Jung, Ramesh Kumar Chitumalla, Joonkyung Jang, Ji-Young Yoon, Ildoo Chung
Summary: In this study, chitosan-based nanogels were developed to provide controlled release of anesthetic drugs for effective postoperative pain management. The nanogels showed high encapsulation efficiencies and computational studies were conducted to evaluate the drug-nanoparticle interaction. In vitro release experiments demonstrated sustained and controlled release of the drug by the nanoparticles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Xiangke Zhang, Ming Chen, Yuping Kan, Yumeng Dong, Xinyu Zhang, Xueying Wang, Hui Su, Shiyi Xu, Xueying Yan
Summary: Doxorubicin and indocyanine green were loaded into silica nanoparticles and wrapped with manganese dioxide to create DOX-IR820@MSN-MnO2 nanoparticles. These nanocomposites exhibit tumor microenvironment response characteristics and excellent photodynamic and photothermal properties. The combination therapy using these nanoparticles significantly reduces cell viability and shows promising applications in cancer treatment.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Samson N. Dada, Godwin K. Babanyinah, Michael T. Tetteh, Victoria E. Palau, Zachary F. Walls, Koyamangalath Krishnan, Zacary Croft, Assad U. Khan, Guoliang Liu, Thomas E. Wiese, Ellen Glotser, Hua Mei
Summary: In this study, folic acid-conjugated carbon dot nanoparticles were prepared to deliver doxorubicin to cancer cells. These nanoparticles exhibited excellent fluorescence properties and showed promising therapeutic effects.
Article
Biotechnology & Applied Microbiology
Mahyar Hesan, Adeleh Gholipour-Kanani, Marzieh Lotfi, Mojtaba Shafiee
Summary: This study aims to synthesize alginate-coated chitosan (ACC) and chitosan-coated alginate (CCA) nanogels as core-shell nanostructured carriers incorporated with mupirocin as an antibiotic. Characterizations are determined by FESEM, TEM, EDS, DLS, zeta potential, and FTIR. The in vitro release study shows high release efficiency. The antibacterial test exhibits good antibacterial properties against both gram-positive and gram-negative bacteria. Overall, CCA and ACC nanogels would be promising substrates in a controlled drug delivery system.
BIOCHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Vijay Sagar Madamsetty, Shima Tavakol, Saeid Moghassemi, Arezoo Dadashzadeh, John D. Schneible, Iman Fatemi, Abdolsamad Shirvani, Ali Zarrabi, Fereshteh Azedi, Ali Dehshahri, Abbas Aghaei Afshar, Kian Aghaabbasi, Abbas Pardakhty, Reza Mohammadinejad, Prashant Kesharwani
Summary: Breast cancer is a highly deadly neoplastic disease with limited efficacy in existing treatment methods, prompting a search for new remedies. Nanotechnology has shown promise in the field, particularly with chitosan as a potential carrier for anticancer drugs. Further research is ongoing to explore the therapeutic and diagnostic applications of chitosan in breast cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biotechnology & Applied Microbiology
Yuan Zhong, Ali Maruf, Kai Qu, Malgorzata Milewska, Ilona Wandzik, Nianlian Mou, Yu Cao, Wei Wu
Summary: Atherosclerosis is a common vascular disease characterized by cholesterol-driven plaque formation in arteries. Trehalose-releasing nanogels (TNG) have been developed to restore impaired autophagy and reduce lipid accumulation, leading to a decrease in atherosclerotic plaques.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ali Maruf, Malgorzata Milewska, Anna Lalik, Sebastian Student, Ilona Wandzik
Summary: In this study, acrylamide-based nanogels containing cationic groups and redox-sensitive crosslinkers were developed for cellular delivery of anti-miR21 (a-miR21). Successful miRNA loading was confirmed and stable miRNA release was achieved.
Article
Chemistry, Physical
Danyang Li, Wenshuang Xu, Hui Liu
Summary: A pH and temperature dual responsive nanogel CS/P(MAA-co-NIPAM) was successfully prepared by radical polymerization, which could rapidly respond to environmental changes and potentially be used for injectable drug delivery. The nanogel exhibited pH and temperature sensitive properties and showed high drug loading and release efficiency, enabling drug delivery in physiological environment.
COLLOID AND POLYMER SCIENCE
(2023)
Article
Oncology
Fatemeh Hashemi, Nasrin Mohajeri, Fatemeh Radnia, Nosratollah Zarghami
Summary: This study presents a biocompatible and affordable fluorescence nanocarrier for cell imaging in cancer therapy. The hybrid nanogel, composed of chitosan polymer, carbon dots (CDs), and an anti-cancer drug, demonstrated successful uptake into breast cancer cells and efficient drug release. The nanocarrier provides both therapeutic compounds and fluorescent agents, enhancing therapeutic efficacy and enabling cellular imaging.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Nanoscience & Nanotechnology
Elizabeth Campbell, Md Tanvir Hasan, Roberto Gonzalez-Rodriguez, Tate Truly, Bong Han Lee, Kayla N. Green, Giridhar Akkaraju, Anton V. Naumov
Summary: This study developed a new multifunctional biocompatible anticancer nanoformulation that provides targeted image-guided cancer therapy, demonstrating capabilities in treatment, imaging, and specific targeting of cancer cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Dickson Pius Wande, Yue Qiu, Shijie Chen, Lan Yao, Yanghui Xu, Jing Yao, Hui Xiong
Summary: This study reports a nanogel-polymersomes drug delivery system for the combination therapy of Oxaliplatin and Rapamycin. The system enhances the apoptosis in cancer cells and overcomes the issues of drug resistance and lack of oral formulation.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Samira Kariminia, Mojtaba Shamsipur, Ali Barati
Summary: Cancer is one of the leading causes of death worldwide, and the development of nano-technology has led to advanced methods for cancer treatment. In this study, fluorescent carbon dots (CDs) were prepared from chitosan and modified with activated folic acid for controlled delivery of the anticancer drug doxorubicin. The results showed high loading efficiency and pH sensitivity of the CDs/CS-FA nanocarrier, making it a potential candidate for controlled drug delivery and cellular imaging.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Chemistry, Multidisciplinary
Rafael Itzhakov, Hagit Hak, Sudharsan Sadhasivam, Eduard Belausov, Elazar Fallik, Ziv Spiegelman, Edward Sionov, Elena Poverenov
Summary: This work successfully delivers bioactive molecules through designing biocompatible nanogel particles (NGPs) using modified nature-sourced building blocks. NGPs are able to deliver drugs and proteins to plant cells, and can co-deliver multiple biomolecules. Furthermore, NGPs successfully encapsulate amphotericin B and reduce its toxicity.
Article
Chemistry, Analytical
Mariana P. Sousa, Ana Margarida L. Piloto, Ana Claudia Pereira, Fernando C. Schmitt, Ruben Fernandes, Felismina T. C. Moreira
Summary: This study developed a CA 15-3 biosensor for ultrasensitive monitoring of breast cancer, which is a simple and sensitive method capable of detecting other molecules of interest in human serum matrices.
Article
Agriculture, Multidisciplinary
Shih-Hsien Liu, Takat B. Rawal, Mikhael Soliman, Briana Lee, Tyler Maxwell, Parthiban Rajasekaran, Hajeewaka C. Mendis, Nicole Labbe, Swadeshmukul Santra, Laurene Tetard, Loukas Petridis
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2019)
Article
Microbiology
Mikaeel Young, Ali Ozcan, Briana Lee, Tyler Maxwell, Thomas Andl, Parthiban Rajasekaran, Melanie J. Beazley, Laurene Tetard, Swadeshmukul Santra
Article
Agriculture, Multidisciplinary
Tyler J. Maxwell, Parthiban Rajasekaran, Smruti Das, Maria G. N. Campos, Mikaeel Young, Hajeewaka C. Mendis, Ali Ozcan, Kayla M. Gerberich, Monty E. Myers, James H. Graham, Evan G. Johnson, Swadeshmukul Santra
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2019)
Article
Microbiology
Tyler Maxwell, Richard G. Blair, Yuemin Wang, Andrew H. Kettring, Sean D. Moore, Matthew Rex, James K. Harper