News Item
Chemistry, Multidisciplinary
Tiffany Piou, Louis-Charles Campeau
Summary: A new method involving an electrochemical process has been successfully developed to synthesize N-alkyl aziridines, which involves a dicationic intermediate.
Article
Business
Herman Aguinis, David B. Audretsch, Caroline Flammer, Klaus E. Meyer, Mike W. Peng, David J. Teece
Summary: This article highlights the neglect of managers in management scholarship and provides four actionable recommendations to incorporate managers into research.
JOURNAL OF MANAGEMENT
(2022)
Article
Economics
Christina Eder, Isabelle Stadelmann-Steffen
Summary: Recently, there has been a growing literature on social tipping dynamics relevant to sustainability. However, the current literature fails to adequately integrate and measure the role of the political sphere, leading to an underestimation of its importance. This study emphasizes the relevance of the political dimension and proposes two ways to integrate it into the analysis of social tipping.
Article
Green & Sustainable Science & Technology
Patricia Elgoibar, Elio Shijaku
Summary: This study explores the impact mechanisms of gender and social capital dimensions on social sustainability, proposing that negotiation may promote social sustainability, and contributes to research on socially driven sustainability trends in organizations.
Article
Chemistry, Physical
Joshua Finkelstein, Chungho Cheng, Giacomo Fiorin, Benjamin Seibold, Niels Gronbech-Jensen
Summary: This paper revises a differential operator splitting method for the Langevin equation in order to comply with the basic GJ thermodynamic sampling features, and concludes that any GJ method has at least weak second order accuracy. It further identifies a novel half-step velocity which produces correct kinetic statistics and transport measures for any of the statistically sound GJ methods.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Editorial Material
Chemistry, Physical
Morgan Trassin, Vincent Garcia
Summary: Sub-100-mV switching at the nanosecond timescale is achieved in ferroelectric devices by approaching bulk-like perfection in prototypical BaTiO3 thin films.
News Item
Chemistry, Multidisciplinary
Antoni Forner-Cuenca
Summary: A simplified electrochemical protocol has been proposed to regenerate the redox-active molecules in aqueous organic redox flow batteries, resulting in extended battery lifetimes.
Article
Development Studies
Ha-Joon Chang, Antonio Andreoni
Summary: From classical economics to modern times, production has always been at the heart of economics, but with the rise of neoclassical economics in the late 19th century, production gradually lost its importance in the field. Opportunities to integrate alternative streams of economics research were missed, and even humanist approaches to development neglected the importance of the production domain. The fragmentation of the production-centered paradigm has weakened both academic research and policy-making related to economic development.
EUROPEAN JOURNAL OF DEVELOPMENT RESEARCH
(2021)
Article
Economics
Kyunghoon Kim, Andy Sumner
Summary: Discussions on industrial policies in developing countries have often overlooked the role of state-owned enterprises. Using the example of Indonesia, this paper demonstrates how many middle-income countries are utilizing state-owned entities to drive structural transformation in their development policies. There is a need to reconsider the debate on the positive role that state-owned entities can play in stimulating structural transformation.
STRUCTURAL CHANGE AND ECONOMIC DYNAMICS
(2021)
Editorial Material
Multidisciplinary Sciences
Meenakshi Wadhwa
Summary: The safe delivery of samples from an asteroid on September 24th will commence a global scientific journey, highlighting the need for support in similar missions.
Article
Environmental Studies
Francesco Cappellano, Christophe Sohn, Teemu Makkonen, Virpi Kaisto
Summary: International borders are not only barriers, but also interfaces, markers of difference, or symbols that play important roles in the innovation-led development in cross-border regions.
ENVIRONMENT AND PLANNING A-ECONOMY AND SPACE
(2022)
Article
Political Science
B. Guy Peters, Jon Pierre, Eva Sorensen, Jacob Torfing
Summary: This paper critically reviews the consequences of the bifurcation of Political Science and Public Administration, highlighting the need for public administration research to incorporate a political science understanding in order to better explain key developments in public services.
GOVERNANCE-AN INTERNATIONAL JOURNAL OF POLICY ADMINISTRATION AND INSTITUTIONS
(2022)
Article
Green & Sustainable Science & Technology
Scott Y. Lin
Summary: The ancient Chinese environmental governance aimed to efficiently manage limited natural resources, but over time, the agenda shifted from rural centrism to urban centrism, from resource management to pollution control, and then to carbon control. With the reshaping of the environmental protection agency by the government, the traditional resource management agenda is re-emerging.
ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY
(2021)
Review
Endocrinology & Metabolism
G. Basile, M. M. F. Qadir, F. Mauvais-Jarvis, A. Vetere, V Shoba, A. E. Modell, R. L. Pastori, H. A. Russ, B. K. Wagner, J. Dominguez-Bendala
Summary: Stem cell therapies are emerging as a viable alternative for treating insulin dependent diabetes. Clinical trials using human embryonic stem cell-derived (3-like cells show promising results. Meanwhile, research on inducing pancreatic cell regeneration through pharmacological means is also promising. However, achieving a permanent cure for diabetes still faces challenges and requires interventions to restore immune balance.
MOLECULAR METABOLISM
(2022)
Article
Business
David B. Audretsch, Erik E. Lehmann
Summary: The main focus of this paper is to summarize what we know, and should know, about narratives and stories in order to consider their importance in the field of entrepreneurship and stimulate future research. The study argues for a 'reverse causality' view, suggesting that narratives and stories can help explain differences and variations in entrepreneurial activities. The implication of this study is that narratives and stories should be included in entrepreneurship research, and it provides directions for future research in this area.
SMALL BUSINESS ECONOMICS
(2023)
Article
Biochemistry & Molecular Biology
Dariya K. Sydykova, Thomas LaBar, Christoph Adami, Claus O. Wilke
JOURNAL OF MOLECULAR EVOLUTION
(2020)
Article
Microbiology
Cory D. DuPai, Claus O. Wilke, Bryan W. Davies
Article
Biochemistry & Molecular Biology
Mackenzie M. Johnson, Claus O. Wilke
JOURNAL OF MOLECULAR EVOLUTION
(2020)
Article
Biochemistry & Molecular Biology
Cory D. DuPai, Bryan W. Davies, Claus O. Wilke
Summary: The beta hairpin motif is a widely distributed protein structural motif known for its stability and adaptability to various functions. Research revealed that specific amino acid preferences within the structure, particularly in the turn region, depend on subtle dynamics associated with turn length and secondary structure. Broad design principles, such as including specific aspartic acid residues and considering desired secondary structure in selecting residues for the turn region, were established for generating libraries encoding proteins or peptides containing beta hairpin structures.
Article
Microbiology
Cory D. Dupai, Ashley L. Cunningham, Aaron R. Conrado, Claus O. Wilke, Bryan W. Davies
Article
Multidisciplinary Sciences
Ashley Teufel, Wu Liu, Jeremy A. Draghi, Craig E. Cameron, Claus O. Wilke
Summary: Viruses experience selective pressure on the timing and order of events during infection. A method has been developed to examine the dynamic phenotypic landscape that viruses must face during replication. Parameters associated with translation and early stage viral replication processes are essential for capturing experimentally observed dynamics.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Adam J. Hockenberry, Claus O. Wilke
Summary: BACPHLIP is a tool that accurately predicts the lifestyle of bacteriophages by detecting conserved protein domains and using a trained classifier. It achieved an accuracy of 98% on a test set, greatly exceeding previous tools.
Article
Biophysics
Anastasiya Kulikova, Daniel J. Diaz, James M. Loy, Andrew D. Ellington, Claus O. Wilke
Summary: The study investigates the use of 3D convolutional neural networks for predicting protein structures from amino acid sequences. The network can accurately predict wild type with good confidence levels, but has less accuracy in predicting consensus, primarily driven by whether or not the consensus matches the wild type. High-confidence mis-predictions of the wild type may indicate sites that are primed for mutation and could be targets for protein engineering.
JOURNAL OF BIOLOGICAL PHYSICS
(2021)
Article
Multidisciplinary Sciences
Sahil B. Shah, Alexis M. Hill, Claus O. Wilke, Adam J. Hockenberry
Summary: This study demonstrates that by varying the placement and strengths of promoters, terminators, and RNase cleavage sites, it is possible to achieve various basic gene expression patterns, without introducing auxiliary gene products.
Article
Biotechnology & Applied Microbiology
T. Jeffrey Cole, Jennifer K. Parker, Aaron L. Feller, Claus O. Wilke, Bryan W. Davies
Summary: Class II microcins are small bacteriocins produced by Gram-negative bacteria in the Enterobacteriaceae, playing a role in interbacterial competition. Despite limited direct evidence, they show a diverse array of molecular functionalities and target specificities, suggesting untapped potential for discovering peptide antibiotics.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniel J. Diaz, Anastasiya V. Kulikova, Andrew D. Ellington, Claus O. Wilke
Summary: Machine and deep learning approaches utilize protein datasets to predict variants with improved fitness. Data availability and quality are more important constraints than the specifics of the algorithms. Even with limited experimental data, pre-training with generic protein datasets can still perform well with subsequent refinement via hybrid or transfer learning. Machine learning approaches will likely have a major role in future breakthroughs in protein biochemistry and engineering.
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Justin R. Randall, Cory D. DuPai, T. Jeffrey Cole, Gillian Davidson, Kyra E. Groover, Sabrina L. Slater, Despoina A. I. Mavridou, Claus O. Wilke, Bryan W. Davies
Summary: This article introduces a method for designing a large peptide library with macrocyclic beta-hairpin structure. Through activity-driven high-throughput screening, dozens of peptides that kill bacteria through selective membrane disruption are identified, and their biochemical features are analyzed using machine learning. Active peptides have a unique constrained structure and are highly enriched in cationic charge with arginine in their turn region. This study provides a synthetic strategy for structured macrocyclic peptide design and discovery, while also elucidating important characteristics for beta-hairpin antimicrobial peptide activity.
Article
Biochemistry & Molecular Biology
Mackenzie M. Johnson, Adam J. Hockenberry, Matthew J. Mcguffie, Luiz Carlos Vieira, Claus O. Wilke
Summary: Variation in gene expression is closely associated with codon usage bias, especially under rapid growth conditions. Growth rate-dependent expression variation is an important constraint that influences the evolution of gene sequences in microorganisms.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Article
Multidisciplinary Sciences
Anastasiya V. Kulikova, Daniel J. Diaz, Tianlong Chen, T. Jeffrey Cole, Andrew D. Ellington, Claus O. Wilke
Summary: This study compares two different types of deep learning models and finds that they have distinct strengths and weaknesses. The overall prediction accuracies between sequence-based and structure-based models are largely uncorrelated. The two structure-based models perform better in predicting buried residues, while the two LLMs perform better in predicting solvent-exposed amino acids. Finally, combining the individual model predictions can significantly improve the overall prediction accuracy.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
James R. Rybarski, Kuang Hu, Alexis M. Hill, Claus O. Wilke, Ilya J. Finkelstein
Summary: A bioinformatic search has led to the discovery of new CRISPR-associated Tn7 transposons (CASTs), revealing different structures and evolution processes of the CAST systems.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)