Article
Multidisciplinary Sciences
R. Janet, N. Costes, I. Merida, E. Derrington, J. C. Dreher
Summary: Serotonin plays a critical role in regulating emotional behavior by modulating excitability and functional connectivity within the corticolimbic circuit. This modulation contributes to individual differences in emotion processing.
SCIENTIFIC REPORTS
(2023)
Article
Psychology, Biological
Zeguo Qiu, Xuqian Li, Alan J. Pegna
Summary: In this study, three backward masking experiments were conducted using multivariate pattern analysis on EEG data to investigate the nonconscious processing of fearful faces under different visual awareness conditions. The results showed that the visibility of the faces was maximally decodable in three time windows, and the spatial location of fearful faces was decodable only when consciously seen and task-relevant. Furthermore, distinct neural patterns associated with the presence of fearful faces were successfully decoded during both short and long presentations. Overall, this study suggests that the processing of fearful faces can occur even when visual awareness is highly restricted.
Article
Multidisciplinary Sciences
Christopher A. Brittin, Steven J. Cook, David H. Hall, Scott W. Emmons, Netta Cohen
Summary: The organization of the animal nervous system is crucial for body functions, relying on features across different scales. The research successfully presented a structure-function model of the main neuropil in the nematode Caenorhabditis elegans, revealing the internal organization and connectivity patterns within the nerve ring.
Article
Neurosciences
Xenia Kobeleva, Ane Lopez-Gonzalez, Morten L. Kringelbach, Gustavo Deco
Summary: The brain rapidly processes and adapts to new information by transitioning between whole-brain functional networks at optimal spatial and temporal scales of around 300 regions and 150 ms, providing evidence for relevant spatiotemporal scales and recommendations for brain dynamics analyses.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Xue Dong, Lijuan Liu, Xinxin Du, Yue Wang, Peng Zhang, Zhihao Li, Min Bao
Summary: This study found that altered-reality adaptation training can improve both the vision and functional connections in the visual cortex of amblyopes. After the training, visual acuities improved in amblyopes and the improvement continued to strengthen for at least one month.
HUMAN BRAIN MAPPING
(2023)
Article
Computer Science, Information Systems
Nguyen Ho, Huy Vo, Mai Vu, Torben Bach Pedersen
Summary: Recent advancements in computing and data technologies have made analyzing Big Data across multiple datasets essential for extracting valuable insights. Techniques need to be fast, scalable, and assist users in prioritizing correlations across different temporal scales to focus on important relationships. AMIC is a method that uses mutual information to identify correlations in large time series, with a focus on scalability and effectiveness.
IEEE TRANSACTIONS ON BIG DATA
(2021)
Article
Genetics & Heredity
Jingxiong Xu, Wei Xu, Jiyeon Choi, Yonathan Brhane, David C. Christiani, Jui Kothari, James Mckay, John K. Field, Michael P. A. Davies, Geoffrey Liu, Christopher I. Amos, Rayjean J. Hung, Laurent Briollais
Summary: This study investigates the contribution of rare variants to lung cancer and identifies CTSL and APOE genes significantly associated with the disease. However, the role of these genetic variants in the regulation of CTSL or APOE expression remains unclear.
Article
Genetics & Heredity
Zhi Wang, Tianqu He, Li Liu, Fangyun Tong, Chuangye Li, Yaowang Zhao, Yanfang Li
Summary: The incidence of urolithiasis (UL) in children is increasing in China. Although the pathogenesis of pediatric UL is controversial, multiple monogenic causes have been identified. This study aims to investigate the prevalence of inherited UL causes and explore the genotype-phenotype correlation in Chinese pediatric patients.
FRONTIERS IN GENETICS
(2023)
Article
Neurosciences
Steve Lukito, Lydia Fortea, Federica Groppi, Ksenia Zuzanna Wykret, Eleonora Tosi, Vincenzo Oliva, Stefano Damiani, Joaquim Radua, Paolo Fusar-Poli
Summary: This meta-analysis aimed to produce an updated brain atlas of emotional face processing. The findings showed that processing of emotional faces is oriented towards identifying threats on faces, with a more complex lateralization pattern than previously theorized. Emotional faces may be processed in latent grouping but organized by threat content rather than emotional valence.
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2023)
Article
Environmental Sciences
Rebecca Langton, David Stirling, Philip Boulcott
Summary: This study developed a model to predict the distribution of northern sea fan habitat. The results showed that a significant proportion of suitable habitat is located within MPAs, suggesting the effectiveness of conservation measures. The study also identified areas that require further management and monitoring.
AQUATIC CONSERVATION-MARINE AND FRESHWATER ECOSYSTEMS
(2023)
Review
Multidisciplinary Sciences
Paola Pinti, Ilias Tachtsidis, Antonia Hamilton, Joy Hirsch, Clarisse Aichelburg, Sam Gilbert, Paul W. Burgess
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2020)
Article
Biochemical Research Methods
Claire Bomkamp, Shreejoy J. Tripathy, Carolina Bengtsson Gonzales, Jens Hjerling-Leffler, Ann Marie Craig, Paul Pavlidis
PLOS COMPUTATIONAL BIOLOGY
(2019)
Article
Biochemical Research Methods
Nisan Ozana, Jack Adam Noah, Xian Zhang, Yumie Ono, Joy Hirsch, Zeev Zalevsky
JOURNAL OF BIOPHOTONICS
(2020)
Article
Biochemistry & Molecular Biology
Marjan Farahbod, Paul Pavlidis
Article
Neurosciences
Olivia Descorbeth, Xian Zhang, J. Adam Noah, Joy Hirsch
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2020)
Article
Neurosciences
Roser Canigueral, Xian Zhang, J. Adam Noah, Ilias Tachtsidis, Antonia F. de C. Hamilton, Joy Hirsch
Summary: The study found that sharing biographical information led to increased eye gaze to the partner's face and facial displays. Spontaneous production and observation of facial displays were associated with activity in different brain regions. Mutual information-sharing increased brain activity and cross-brain synchrony, suggesting the involvement of complex neurocognitive mechanisms during information-sharing.
Article
Neurosciences
Yumie Ono, Xian Zhang, J. Adam Noah, Swethasri Dravida, Joy Hirsch
Summary: This study aims to understand the neural dynamics of spoken dialogue between two individuals. It reveals that the connectivity between speech areas in the brain is modulated by social interaction, with interactive communication showing bidirectional connectivity and noninteractive communication showing unidirectional connectivity.
BRAIN CONNECTIVITY
(2022)
Article
Neurosciences
James Crum, Xian Zhang, Adam Noah, Antonia Hamilton, Ilias Tachtsidis, Paul W. Burgess, Joy Hirsch
Summary: This study developed a paradigm to fractionate the major components of human-to-human verbal interactions occurring in clinical situations and used functional near-infrared spectroscopy to assess the brain systems underlying clinician-client discourse. The results showed significantly greater cross-brain neural coupling between people during clinical interactions compared with everyday life verbal communication.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Article
Genetics & Heredity
J. Michael Harnish, Lucian Li, Sanja Rogic, Guillaume Poirier-Morency, Seon-Young Kim, Kym M. Boycott, Michael F. Wangler, Hugo J. Bellen, Philip Hieter, Paul Pavlidis, Zhandong Liu, Shinya Yamamoto
Summary: Next-generation sequencing is an important diagnostic tool for rare disease gene discovery. Collaboration between scientists, clinicians, and patients is crucial for resolving medical mysteries and understanding human gene function. Interaction between scientists and research funders can accelerate the translation of discoveries into therapeutic research.
Article
Multidisciplinary Sciences
Joy Hirsch, Xian Zhang, J. Adam Noah, Swethasri Dravida, Adam Naples, Mark Tiede, Julie M. Wolf, James C. McPartland
Summary: Reluctance to make eye contact is a key diagnostic criterion for autism spectrum disorder (ASD). This study used neuroimaging, eye-tracking, and pupillometry to investigate the neural correlates of eye-to-eye contact in individuals with ASD and typically-developed individuals. The results revealed decreased activity in the right dorsal-parietal region and increased activity in the right ventral temporal-parietal region in ASD during live eye-to-eye contact. These neural responses were associated with social performance measures and indicate that social characteristics in ASD are linked to neural responses during eye contact.
Article
Biochemistry & Molecular Biology
Alexander Morin, Eric Ching-Pan Chu, Aman Sharma, Alex Adrian-Hamazaki, Paul Pavlidis
Summary: In this study, a workflow for identifying, processing, and aggregating ChIP-seq and TR perturbation experiments was developed to rank human and mouse TR-target interactions. Through analyzing these two types of data, systematic patterns and putative orthologous interactions between human and mouse were identified. Additionally, empirically ranked TR-target listings and transparent experiment-level gene summaries were provided for community use.
Article
Biology
Joy Hirsch, Xian Zhang, J. Adam Noah, Aishwarya Bhattacharya
Summary: Research shows that viewing someone's facial expression can lead to the observer expressing a similar expression and experiencing a similar emotion. The model of embodied emotion proposes a functional link between emotional contagion and facial mimicry, although the neural mechanisms are not known.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Linguistics
Eric S. Jackson, Swethasri Dravida, Xian Zhang, J. Adam Noah, Vincent Gracco, Joy Hirsch
Summary: People who stutter are able to anticipate their stuttering events, and this anticipation is associated with neural activity in the right dorsolateral prefrontal cortex (R-DLPFC) and the frontoparietal network (FPN). Stutterers exhibit increased activation in the R-DLPFC, and anticipated words are associated with reduced connectivity between the R-DLPFC and the right supramarginal gyrus (R-SMG). These findings have important implications for future clinical research.
NEUROBIOLOGY OF LANGUAGE
(2022)
Article
Mathematical & Computational Biology
Nathaniel Lim, Stepan Tesar, Manuel Belmadani, Guillaume Poirier-Morency, Burak Ogan Mancarci, Jordan Sicherman, Matthew Jacobson, Justin Leong, Patrick Tan, Paul Pavlidis
Summary: Despite the vast amount of transcriptomic data in public repositories, effective reuse remains challenging due to issues such as unstructured metadata, inconsistent data processing, and varying probe-gene mappings. The Gemma bioinformatics system was created to address these issues by providing curated transcriptomic datasets, analytical software, and a web interface. With over 10,000 manually curated datasets and hundreds of curated transcriptomic platforms, Gemma offers broad coverage of conditions and tissues, particularly focusing on brain-related datasets. Users can access the curated data and differential expression analyses through the Gemma website, RESTful service, and an R package.
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
(2021)
Article
Biology
Anthony J. E. Berndt, Katerina M. Othonos, Tianshun Lian, Stephane Flibotte, Mo Miao, Shamsuddin A. Bhuiyan, Raymond Y. Cho, Justin S. Fong, Seo Am Hur, Paul Pavlidis, Douglas W. Allan